The use of infliximab in ocular inflammation

Prendiville, Catherine; O'Doherty, M; Moriarty, Paul; Cassidy, Lorraine

doi:10.1136/bjo.2006.111666

Cited by 20 publications

(21 citation statements)

References 18 publications

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“…76 Infliximab has been successfully used to treat optic neuropathy refractory to other treatments. 71,77,78 However, the drug is associated with significant toxicity including increased risk for tuberculosis and fungal infections, worsening congestive heart failure, and potential increased risk for malignancy. 79 Infliximab rarely can cause optic neuropathy and demyelinating peripheral and central diseases.…”

Section: Management Of Neuro-ophthalmic Sarcoidosismentioning

confidence: 99%

Neuro-ophthalmic sarcoidosis

Baughman¹,

Weiss²,

Golnik³

2012

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Neuro-ophthalmic disease occurs in about a third of patients with neurosarcoidosis. Optic nerve involvement is the most common manifestation, but other cranial nerves and the optic chiasm can be involved. However, there are several other common diseases that cause optic neuropathy, including multiple sclerosis. The diagnosis of sarcoidosis can often be made based on the multi-organ nature of the disease and ancillary testing. Most patients with neuro-ophthalmic sarcoidosis require systemic therapy. While corticosteroids are usually the first step in therapy, cytotoxic agents such as methotrexate and azathioprine have been useful as steroid-sparing agents for chronic disease. The monoclonal antibodies directed against tumor necrosis factor have been reported as effective in refractory cases of neuro-ophthalmic disease.

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Section: Management Of Neuro-ophthalmic Sarcoidosismentioning

confidence: 99%

Neuro-ophthalmic sarcoidosis

Baughman¹,

Weiss²,

Golnik³

2012

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“…102 Crion has clinical features similar to neurosarcoidosis, but with no sign of lesion dissemination even after prolonged followup. 103 the classic description is one of a relapsing-remitting condition reVIews characterized by prompt relief with steroid tr eatment and rapid recurrence on steroid withdrawal. 102,103 Patients with Crion present with unilateral or bi lateral subacute optic neuropathy, typically associated with pain followed by visual loss.…”

Section: Crionmentioning

confidence: 98%

“…103 the classic description is one of a relapsing-remitting condition reVIews characterized by prompt relief with steroid tr eatment and rapid recurrence on steroid withdrawal. 102,103 Patients with Crion present with unilateral or bi lateral subacute optic neuropathy, typically associated with pain followed by visual loss. 102 in the acute presentation, the appearance of the optic nerve head varies from unremark able through mild disc edema to optic disc pallor.…”

Section: Crionmentioning

confidence: 98%

“…102 in the acute presentation, the appearance of the optic nerve head varies from unremark able through mild disc edema to optic disc pallor. 102,103 Generally, bilateral edema is the presenting feature, with a minority of patients presenting with optic nerve head pallor. 102 Given the rarity of this condition, few research publications have described the chronic changes in optic nerve head morphology.…”

Section: Crionmentioning

confidence: 99%

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The optic nerve head in acquired optic neuropathies

et al. 2010

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Acquired optic neuropathies are a common cause of blindness in adults, and are associated with characteristic morphological changes at the optic nerve head. Accurate and prompt clinical diagnosis, supplemented with imaging where appropriate, is essential to optimize management of the optic neuropathy and to counsel the patient appropriately on its natural history. History taking, optic disc findings, visual field assessment and imaging of the nerve head and surrounding retinal nerve fiber layer are all paramount to achieving the correct diagnosis. This Review highlights the optic nerve head features that are common to the acquired optic neuropathies, and describes the features that can be used to differentiate these various conditions.

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“…Given these restrictions, there is an obvious demand for the development of new therapeutic strategies. Indeed, many alternative approaches, including antioxidants [11,12,26] and anticytokine therapies (such as anti-TNF) have been shown to prevent ocular inflammation in experimental animals [11,12]. DSF has long been used to treat alchoholic syndrome without severe side effects [14].…”

mentioning

confidence: 99%

Anti-Inflammatory Potency of Oral Disulfiram Compared with Dexamethasone on Endotoxin-Induced Uveitis in Rats

et al. 2011

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ABSTRACT. To investigate potency of oral disulfiram (DSF) compared with that of dexamethasone (Dexa), on endotoxin-induced uveitis (EIU) in rats. The oral administration with 750 mg/kg DSF suppressed the number of inflammatory cells, protein concentration, and levels of tumor necrosis factor (TNF)-, Nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor and improved the histiologic status of the ocular tissue at 24 hr after lipopolysaccharide (LPS) injection. The anti-inflammatory potency of DSF oral administration was as strong as that observed with 0.5 mg/kg Dexa in the present study. The results suggest that DSF might pave the way for a novel therapeutic agent for the management of uveitis.KEY WORDS: anti-inflammatory potency, dexamethasone, diethyldithiocarbamate, disulfiram, endotoxin-induced uveitis.J. Vet. Med. Sci. 73(4): 517-520, 2011 Endotoxin-induced uveitis (EIU) is an animal model for acute ocular inflammation [17]. In general, cellular inflammation in EIU starts 4 hr after injection of LPS, with maximum infiltration after 18-24 hr [24]. The Although the contributions of tumor necrosis factor (TNF)-α are pleiotropic [10,16,18], the TNF-α, Interleukin (IL)-1β and IL-6 are considered to be particularly essential in the pathogenesis of EIU [3,4,25]. Nitric oxide (NO) [8] and prostaglandin (PG) E2 [1] are also involved in the pathogenesis of EIU. Disulfirum (DSF), as a prodrug of diethyldithiocarbamate (DDC), has long been used for the treatment of alcoholic syndrome without severe side effects [14]. DSF is cleaved into DDC within the gastrointestinal tract by oral administration. DSF has been reported to have multiple biological properties, including anti-inflammatory [23], anti-cataract [7], and anti-tumor properties [2]. We previously reported that oral DSF administration significantly reduced the development of EIU in a dose-dependent manner and 750 mg/kg DSF was most effective in inhibiting LPS-induced elevation of number of infiltrating cells, protein concentration and inflammatory mediators in aqueous humor [9], but did not compare DSF with corticosteroids which was the primary treatments available for uveitis. In our present study, therefore, we focused our attention on the antiinflammatory potency of 750 mg/kg DSF compared with that of 0.5 mg/kg dexamethasone (Dexa).Seven-week-old male Lewis rats were used. The rats weighed 180-220 g. After appropriately anesthetized with isoflurane, EIU was induced by injection into one footpad of 200 μg of LPS from Salmonella typhimurium (Sigma-Aldrich, St. Louis, MO, U.S.A.) that had been diluted in 0.1 ml of phosphate buffered saline (pH 7.4 PBS). Rats were orally administered 750 mg/kg of DSF (Sigma-Aldrich) diluted in 0.4 ml of 0.5% w/v dimethyl sulfoxide (DMSO; Sigma-Aldrich). DSF was orally administered 1 hr prior to LPS injection via gastic gavage. For the LPS and control group, 0.4 ml of 0.5% w/v DMSO was given orally on the same schedule as the DSF group. Dexa was administered in rats as described previously [15]. Briefly, animals were ...

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The use of infliximab in ocular inflammation

Abstract: This report highlights the expanding role of the biological agents in ophthalmology. Although not the answer in treatment, they offer a valuable alternative to steroids in cases of refractory inflammation.

Cited by 20 publications

References 18 publications

Neuro-ophthalmic sarcoidosis

Neuro-ophthalmic sarcoidosis

The optic nerve head in acquired optic neuropathies

Anti-Inflammatory Potency of Oral Disulfiram Compared with Dexamethasone on Endotoxin-Induced Uveitis in Rats

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