The Use of Hyaluronidase as an Adjunct to Surgical Procedures

Clark, Lani E.; Mellette, J. Ramsey

doi:10.1111/j.1524-4725.1994.tb03718.x

Cited by 31 publications

(22 citation statements)

References 8 publications

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“…The washout effect of the tumescent solution also leads to antibacterial effects. Addition of hyaluronidase to local anesthetic offers the benefit of minimizing loss of surface contour and enhanced ease of dissection through subcutaneous tissue planes [13]. In addition to various advantages, a few disadvantages were associated with tumescent local anesthesia in our case, namely, wet surgical field, time-consuming infiltration, and multiple injections.…”

Section: Discussionmentioning

confidence: 85%

Severe post-burn neck contracture release and skin graft harvest using tumescent local anaesthesia as the sole anesthetic technique

et al. 2011

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Severe post-burn contractures in the neck often cause anatomical distortion and restriction of neck movements, resulting in varying degrees of difficulty in airway management. Any mode of anesthesia that may obviate the need for imperative airway control may be desirable in such situations in which a difficult airway may be anticipated. Here we present one such situation where tumescent local anesthesia was employed to manage a case of severe post-burn neck contractures posted for contracture release and split-skin grafting. The other benefits of this method were minimal blood loss and excellent postoperative analgesia. In conclusion, it can be emphasized that the application of tumescent anesthesia is an important anesthetic tool in patients with predicted difficult airway management.

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Section: Discussionmentioning

confidence: 85%

Severe post-burn neck contracture release and skin graft harvest using tumescent local anaesthesia as the sole anesthetic technique

et al. 2011

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“…The time of macroscopic wound closure in the test area (photographic proof of complete epithelization) and the degree of hemovascular perfusion (laser-Doppler flow) at baseline and on Days 0, 4,7,8,9,10,11,12,13, and 14 were determined as secondary target parameters.…”

Section: Secondary Target Parametersmentioning

confidence: 99%

Clinical Trial for Safety Evaluation of Hyaluronidase as Diffusion Enhancing Adjuvant for Infiltration Analgesia of Skin with Lidocaine

Wohlrab

Finke

Franke

et al. 2012

Dermatologic Surgery

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“…This would allow coadministration of a second drug by directly incorporating them in the same delivery system and administering both drugs as a single dosage form. Few studies demonstrated that the efficacy of anticancer drug [6] and local anesthetics [4, 7] could be improved by pretreating the target site with hyaluronidase.…”

Section: Introductionmentioning

confidence: 99%

Application of Experimental Design in Preparation of Nanoliposomes Containing Hyaluronidase

Kasinathan

Volety

Josyula

2014

Journal of Drug Delivery

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Hyaluronidase is an enzyme that catalyzes breakdown of hyaluronic acid. This property is utilized for hypodermoclysis and for treating extravasation injury. Hyaluronidase is further studied for possible application as an adjuvant for increasing the efficacy of other drugs. Development of suitable carrier system for hyaluronidase would help in coadministration of other drugs. In the present study, the hyaluronidase was encapsulated in liposomes. The effect of variables, namely, phosphatidylcholine (PC), cholesterol, temperature during film formation (T 1), and speed of rotation of the flask during film formation (SPR) on percentage of protein encapsulation, was first analyzed using factorial design. The study showed that level of phosphatidylcholine had the maximum effect on the outcome. The effect of interaction of PC and SPR required for preparation of nanoliposomes was identified by central composite design (CCD). The dependent variables were percentage protein encapsulation, particle size, and zeta potential. The study showed that ideal conditions for production of hyaluronidase loaded nanoliposomes are PC—140 mg and cholesterol 1/5th of PC when the SPR is 150 rpm and T 1 is 50°C.

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The Use of Hyaluronidase as an Adjunct to Surgical Procedures

Abstract: We therefore recommend the adjunct of hyaluronidase to local anesthesia as a useful advancement in surgical technique.

Cited by 31 publications

References 8 publications

Severe post-burn neck contracture release and skin graft harvest using tumescent local anaesthesia as the sole anesthetic technique

Severe post-burn neck contracture release and skin graft harvest using tumescent local anaesthesia as the sole anesthetic technique

Clinical Trial for Safety Evaluation of Hyaluronidase as Diffusion Enhancing Adjuvant for Infiltration Analgesia of Skin with Lidocaine

Application of Experimental Design in Preparation of Nanoliposomes Containing Hyaluronidase

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