The use of high tumescent power assisted liposuction in the treatment of Madelung’s collar

Witmanowski, Henryk; Banasiak, Łukasz; Kierzynka, Grzegorz; Markowicz, Jarosław; Kolasiński, Jerzy; Błochowiak, Katarzyna; Szychta, Paweł

doi:10.5114/ada.2017.69319

Cited by 4 publications

(3 citation statements)

References 37 publications

(40 reference statements)

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“…42 It is true that there are no studies connecting the role of alcohol in MSL pathogenesis, and stopping alcohol consumption did not reverse or prevent disease development, although other studies suggested that alcohol could be a key MSL promoter and delay ATLLM formation. 4,43,44 Our current data supported the notion that alcohol is considered to be a crucial factor for MSL development. In addition, most of our patients had mild metabolic dysfunction, and Zolotov et al reported high levels of TG in three patients.…”

Section: Discussionsupporting

confidence: 87%

“…3 The MSL incidence rate is 1:25,000 in the Mediterranean region but is very low among Asian populations, and the age of onset is usually between 30 and 70 years old in men, occurring up to 30 times more frequently in men than in women. 4,5 Although most MSL cases occur sporadically, it has also been reported in hereditary family MSL. [6][7][8][9] The cause of the disease remains unknown, but alcohol abuse is an important risk factor in MSL development and avoidance of alcohol consumption may prevent disease progression.…”

Section: Introductionmentioning

confidence: 99%

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<p>Cbl Proto-Oncogene B (CBLB) c.197A>T Mutation Induces Mild Metabolic Dysfunction in Partial Type I Multiple Symmetric Lipomatosis (MSL)</p>

Chen

Wan

Zhao

et al. 2020

DMSO

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Background: Multiple symmetric lipomatosis (MSL) is a rare disease showing chronic progression of multiple, symmetrical, and non-encapsulated subcutaneous lipoma. The cause of the disease remains unknown. Patients and Methods: This study reported and summarized 13 sporadic cases of Type I MSL patients in terms of histopathology and cellular and molecular biology and assessed the CBLB c.197A>T mutation in the IRS1-PI3K-Akt pathway. Results: The clinical data showed that these 13 Type I patients were all male with a mean age of 57.0 ± 6.6 years old and consumed alcohol heavily. The laboratory tests revealed that most of the patients had hyperuricemia, diabetes, hyperinsulinemia, or insulin resistance; however, their blood lipid levels were close to a normal range. The imaging data exhibited lipomas that only occurred subcutaneously but not viscerally, ie, Types Ia (15.4%), Ib (30.8%), and Ic (53.8%). The molecular analyses of adipocytes of isoprenaline stimulated human adipose tissue-derived mesenchymal stromal cells (hADSCs) isolated from the adipose tissue lipoma-like masses (ATLLM) demonstrated that these adipocytes did not express UCP-1. The Cbl proto-oncogene B (CBLB), an E3 ubiquitin-protein ligase, was associated with insulin resistance and obesity and was mutated (ie, CBLB c.197A>T) in four MSL patients after the whole genome and Sanger sequencing of the blood samples. Furthermore, the CBLB c.197A>T mutation induced hADSC resistance to insulin by inactivation of the IRS-1-PI3K-AKT pathway. Conclusion: This study analyzed clinical, histopathological, and cellular and molecular biological characterizations of 13 Type I MSL patients and identified the CBLB c.197A>T heterozygous mutation that could be responsible for MSL metabolic dysfunction or even MSL development.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

<p>Cbl Proto-Oncogene B (CBLB) c.197A>T Mutation Induces Mild Metabolic Dysfunction in Partial Type I Multiple Symmetric Lipomatosis (MSL)</p>

Chen

Wan

Zhao

et al. 2020

DMSO

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“…As shown in Figure 1, this classification defines three phenotypes and subtypes of MSL. The most common, recognizable, and aesthetically displeasing form of MSL is Phenotype I, also known as Madelung collar (Witmanowski et al, 2017). In Phenotype I MSL, the adipose tissue is concentrated and spread around the neck like a collar.…”

mentioning

confidence: 99%

Multiple Symmetric Lipomatosis: Lipectomy for Madelung Collar

Đuc¹,

Lam²,

Hải³

et al. 2022

Plastic and Aesthetic Nursing

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and edited the article. V.N.L. and N.T.N. equally designed and conducted the experiment. N.Q.D. and V.N.L. studied scientific literature about the topic. All authors read and approved the final manuscript. This study complied with the Declaration of Helsinki in relation to medical research involving human subjects and got consent from the Research Ethics Committee of the 108 Institute of Clinical Medical and Pharmaceutical Sciences. Informed consent was obtained from all individual participants included in the study. All patients provided written consent for publication of their photographs and surgery outcomes.

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Multiple Symmetric Lipomas: A Case Report

Feng

Cai

et al. 2020

Chinese Journal of Plastic and Reconstructive Surgery

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The use of high tumescent power assisted liposuction in the treatment of Madelung’s collar

Cited by 4 publications

References 37 publications

<p>Cbl Proto-Oncogene B (CBLB) c.197A>T Mutation Induces Mild Metabolic Dysfunction in Partial Type I Multiple Symmetric Lipomatosis (MSL)</p>

<p>Cbl Proto-Oncogene B (CBLB) c.197A>T Mutation Induces Mild Metabolic Dysfunction in Partial Type I Multiple Symmetric Lipomatosis (MSL)</p>

Multiple Symmetric Lipomatosis: Lipectomy for Madelung Collar

Multiple Symmetric Lipomas: A Case Report

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