The use of heparin in infertility and recurrent pregnancy loss: Are its antiviral properties at play?

Eliassen, Eva; Marci, Roberto; Luca, Dario Di; Rizzo, Roberta

doi:10.1016/j.mehy.2017.03.009

Cited by 7 publications

(7 citation statements)

References 72 publications

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“…Miscarriage and infertility are prevalent around the world and in many cases, the causes are unknown. HHV-6 (particular HHV-6A) is an etiological agent or a risk factor in a portion of these cases (7,11,12) . In this study, HHV-6 DNA positivity was detected in 20% of miscarriage endometrial tissue while the uterus lining tissue of control group showed HHV-6 DNA in 22.22%.…”

Section: Discussionmentioning

confidence: 99%

“…However microbial infections have been characterized as a major cause in abortion, of which viruses appear to be the most frequently involved pathogens (9,10) . HHV-6 has been implicated in cases of poor pregnancy outcome due to ability of virus to disrupt endometrium epithelial cells function that lead to inhibit the creation of appropriate uterine environment for implantation and fetal growth that lead to infertility and miscarriage (11) . In 2016, HHV-6A was found in endometrial biopsies from primary unexplained infertile women, but not in control women.…”

Section: Introductionmentioning

confidence: 99%

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Association of Human Herpes Virus 6a Infection in Endometrial Epithelial Cells With Miscarriage

Dosh¹,

Abdulamir²,

Abdul-Razzaq³

2019

IraqiJMS

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Background: The microbial infections are major cause in abortion, of which viruses appear to be the most frequently involved pathogens. Human Herpes Virus-6 (HHV-6) has been implicated in cases of poor pregnancy outcome. Objective: Detection and quantification of HHV-6 viral load along with titer of IgM and IgG in endometrial epithelial cells of women with unexplained miscarriage (cases group) compared to the decidual endometrial tissue in women with full term conception (the control group). Methods: A total of 90 samples, 45 were taken by curettage from miscarriage women at first and second trimesters of pregnancy and 45 were taken from women with full term pregnancy during caesarian operation. HHV-6 DNA was extracted from uterus lining tissue samples, and then it was detected and measured by real time qPCR; in addition, 3 ml of blood were collected from each subject for detection of HHV-6 IgM and IgG antibodies. Results: HHV-6 DNA was detected in uterus lining tissue of 20% of abortion and 22.22% of controls (P value=0.79). The median viral load of HHV-6 per 106 of uterine cells in abortion group was 15, while for control group was 13 (P=0.54). HHV-6 load increased with increased number of previous abortions, and it increased with presence of recurrent abortion history. It showed significant differences in the median of HHV-6 DNA load between recurrent abortion and non-recurrent abortion groups (P value =0.033). Positive anti-HHV-6 IgM serum antibodies in HHV-6 DNA detected and no-detected subjects were 0%, and 9.85% respectively; the positive anti-HHV-6 IgG serum antibodies in detected HHV-6 DNA were 100%, while 83% in HHV-6 DNA non-detected subjects. The combination of positive/negative results of the anti-HHV-6 IgG and IgM serum antibodies in HHV-6 DNA detected versus non-detected group showed 100% of HHV-6 DNA detected were positive for IgG and negative for IgM, versus 73% in non-detected group. Conclusion: HHV-6 might associated with unexplained miscarriage. HHV-6 infection might increase with increased number of previous abortions, and increased with presence of recurrent abortion history. Keywords: Human Herpes Virus 6A, Miscarriage Citation: Dosh HS, Abdulamir AS, Abdul-Razzaq SH. Association of Human Herpes Virus 6A infection in endometrial epithelial cells with miscarriage. Iraqi JMS. 2019; 17(1): 57-65. doi: 10.22578/IJMS.17.1.9

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Human Herpes Virus 6a Infection in Endometrial Epithelial Cells With Miscarriage

Dosh¹,

Abdulamir²,

Abdul-Razzaq³

2019

IraqiJMS

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“…We first reported HHV-6A DNA presence in 43% of endometrial cells from women with idiopathic infertility, whereas no fertile control women harbored the virus 1 . Growing evidence confirms this implication [1][2][3][4][5][6] . We investigated the effect of HHV-6A infection on the immunological status of the endometrium.…”

Section: Objectivementioning

confidence: 96%

Endometrium infection by human herpesvirus-6A: implication in female idiopathic infertility

Rizzo

Luca

2018

Fertility and Sterility

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OBJECTIVE: A possible association between allergy and infertility has not been investigated. Our aim was to determine whether female allergy correlates with infertility treatment outcomes. DESIGN: Retrospective cohort study in an academic medical center. MATERIALS AND METHODS: Patient data from July 2010 through January 2017 was compiled from medical records. Mixed effects models were used to evaluate the relationship between presence of female allergy and type (fresh or FET) and cycle outcomes, controlling for type of procedure, number of embryos transferred, female patient age, BMI, smoking status, gravidity, parity, and Caucasian race. RESULTS: After exclusions for missing data, the cohort contained 493 patients with a total of 935 cycles. Of these, 90.7% identified as Caucasian with a mean age of 34.8 (SD¼4.6) at the time of each cycle initiation. Over half of the female patients had allergy (54.0%). Nonexclusively, among all female patients, allergy to antibiotics was most common (29.2%), followed by allergy to non-antibiotic prescription medications (22.3%). Allergies to pollen and dust (5.7%), foods (6.5%), latex (4.4%) and other substances (9.7%) including cat and dog allergens were less common. Among cycles with fresh embryo transfer (581 cycles from 408 patients), having an allergy to pollen and/or dust was significantly associated with having a negative beta-hCG test (p¼0.02). Pollen/dust allergy was not associated with SAB, biochemical pregnancy, or ectopic pregnancy alone; however, it was associated with whether an infant was born at the end of the cycle (p¼0.04), with only 15.4% of those with a pollen/dust allergy having a cycle which resulted in a live-born infant compared with 34.7% of those without such allergy. Overall, the presence of any allergy was not associated with negative beta-hCG or pregnancy outcomes, nor was other sub-classes of allergies. CONCLUSIONS: The high rates of allergy among patients seeking infertility treatment, as compared to the general population, are surprising. Female allergy to pollen and/or dust is associated with a greater chance of failed fertility treatment and a lower chance of a successful pregnancy resulting in a live-born infant. The reproductive performance of allergic patients needs further investigation using a larger dataset.

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“…OBJECTIVE: We first reported HHV-6A DNA presence in 43% of endometrial cells from women with idiopathic infertility, whereas no fertile control women harbored the virus 1 . Growing evidence confirms this implication [1][2][3][4][5][6] . We investigated the effect of HHV-6A infection on the immunological status of the endometrium.…”

mentioning

confidence: 96%

“…OBJECTIVE: Patients with significantly elevated or diminished BMI may exhibit a variety of health consequences and decreased fecundity. The reproductive impact of elevated BMI has been well studied, but few studies have convincingly quantified the effects of low BMI on oocyte/embryo quality and implantation efficacy [1][2][3][4][5][6] . This study aimed to determine the impact of low BMI on ovarian response to controlled ovarian stimulation (COS) for IVF.…”

mentioning

confidence: 99%

High prevalence of allergy in patients undergoing assisted reproductive technology: a conundrum

Esfandiari

Cruz

Litzky

et al. 2018

Fertility and Sterility

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Patients in all BMI groups had similar gravidity, parity, and cycle characteristics, including endometrial thickness, percent of embryos biopsied for preimplantation genetic testing for aneuploidy (PGT-A), day of embryo biopsy, and blastocyst morphology. CP rate did not differ among BMI groups. There were also no differences in OP/LB (p¼0.78), EPL (p¼0.37), and CPL rates (p¼0.88) among BMI groups, before and after adjusting for confounders.CONCLUSIONS: While the maternal metabolic environment adversely affects IVF outcomes in obese women, the mechanism of action is not fully understood. Following transfer of a single, frozen blastocyst in OD cycles, overweight and obese patients had similar CP, OP/LB, EPL, and CPL rates compared to controls. This study is the first to evaluate the impact of obesity on implantation, independent of oocyte quality, and confirms that maternal obesity exhibits minimal effect on the endometrium. Future studies of the endometrial transcriptome and metabolome may improve our understanding of the impact of nutritional status and obesity on endometrial receptivity.

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The use of heparin in infertility and recurrent pregnancy loss: Are its antiviral properties at play?

Cited by 7 publications

References 72 publications

Association of Human Herpes Virus 6a Infection in Endometrial Epithelial Cells With Miscarriage

Association of Human Herpes Virus 6a Infection in Endometrial Epithelial Cells With Miscarriage

Endometrium infection by human herpesvirus-6A: implication in female idiopathic infertility

High prevalence of allergy in patients undergoing assisted reproductive technology: a conundrum

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