High prevalence of allergy in patients undergoing assisted reproductive technology: a conundrum

Abstract

Patients in all BMI groups had similar gravidity, parity, and cycle characteristics, including endometrial thickness, percent of embryos biopsied for preimplantation genetic testing for aneuploidy (PGT-A), day of embryo biopsy, and blastocyst morphology. CP rate did not differ among BMI groups. There were also no differences in OP/LB (p¼0.78), EPL (p¼0.37), and CPL rates (p¼0.88) among BMI groups, before and after adjusting for confounders.CONCLUSIONS: While the maternal metabolic environment adversely affects IVF outcomes in obese women, the mechanism of action is not fully understood. Following transfer of a single, frozen blastocyst in OD cycles, overweight and obese patients had similar CP, OP/LB, EPL, and CPL rates compared to controls. This study is the first to evaluate the impact of obesity on implantation, independent of oocyte quality, and confirms that maternal obesity exhibits minimal effect on the endometrium. Future studies of the endometrial transcriptome and metabolome may improve our understanding of the impact of nutritional status and obesity on endometrial receptivity.