The Use of Genetic Markers in the Clinical Care of Patients With Head and Neck Cancer

Friedlander, Paul L.

doi:10.1001/archotol.129.3.363

Cited by 12 publications

(6 citation statements)

References 22 publications

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“…It has been reported that serum levels of Periostin were elevated in patients with breast cancer, nonsmall-cell lung cancer and thymoma (Sasaki et al, 2001a, b and2003). In fact, we detected Periostin in condition media of oral cancer cell lines with high expression of Periostin (Kudo et al, 2006).…”

Section: Discussionsupporting

confidence: 47%

“…Individual tumour behaviour varies greatly, with some tumours growing slowly and others rapidly or metastasising early. Despite aggressive and multidisciplinary treatment approaches, including preoperative or postoperative chemotherapy and/or radiotherapy with reconstructive surgery, there has been no significant improvement in 5-year survival over the past 20 years (Friedlander, 2003). Review of literature indicated that the most important factor for high mortality rate is the advanced stage of the disease at the time of diagnosis and treatment.…”

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confidence: 99%

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Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

et al. 2006

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Oral squamous-cell carcinoma (OSCC) is one of the most common types of human cancer. Typically OSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. We previously identified Periostin as the gene demonstrating the highest fold change expression in the invasive clone by comparing the transcriptional profile of parent OSCC cell line and a highly invasive clone. Here, we demonstrated that Periostin overexpression enhanced invasiveness in oral cancer cell lines. To know the role of Periostin in invasion, angiogenesis and metastasis in OSCC cases, we first examined the expression of Periostin mRNA in 31 OSCC cases by RT -PCR and Periostin protein in 74 OSCC cases by immunohistochemistry. Then, we compared the Periostin expression with invasion pattern, metastasis and blood vessel density. Periostin mRNA and protein overexpression were frequently found in OSCC cases and Periostin expression was well correlated with the invasion pattern and metastasis. Moreover, blood vessel density of Periostin-positive cases was higher than those of Periostin-negative cases. Interestingly, recombinant Periostin enhanced capillary formation in vitro in a concentration-dependant manner. In summary, these findings suggest that Periostin may promote invasion and angiogenesis in OSCC, and that Periostin can be a strong marker for prediction of metastasis in oral cancer patients.

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Section: Discussionsupporting

confidence: 47%

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confidence: 99%

Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

et al. 2006

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“…5,6 Although this approach holds promise, it has not yet identified a proven prognostic marker. 7 An important advance in cancer imaging has been the development of positron emission tomography (PET). Unlike CT or MRI, PET is a physiological imaging technique.…”

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confidence: 99%

FDG-PET Prediction of Head and Neck Squamous Cell Cancer Outcomes

Schwartz¹,

Rajendran²,

Yueh³

et al. 2004

Arch Otolaryngol Head Neck Surg

179

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To confirm that high pretreatment uptake of 2-deoxy-2[ 18 F]fluoro-D-glucose (FDG) detected by positron emission tomography (PET) measured at the primary head and neck squamous cell carcinoma (HNSCC) and at metastatic nodal disease predicts poor outcomes for HNSCC. Design and Patients: We enrolled 63 consecutive patients with a histological diagnosis of HNSCC (including tumors of the oral cavity, oropharynx, larynx, and hypopharynx) from September 2000 through June 2003, into a prospective institutional imaging trial. Fifty-four patients (86%) underwent a baseline FDG-PET scan before curative treatment and were eligible for analysis. Results: A primary tumor standardized uptake value (SUV) of greater than 9.0 predicted inferior local recurrence-free survival (P = .02) and disease-free survival (P=.03). Nodal SUV dichotomized according to the co-hort median of 6.1 did not predict for either disease outcome (P =.71 and P=.98, respectively). On proportional hazards analysis, local recurrence and disease event hazard ratios for a primary tumor SUV of 9.0 or greater remained significant or at borderline significance when adjusted for nodal SUV or other clinical covariates. Conclusions: Our findings support an association between baseline primary tumor FDG SUV and HNSCC outcomes. In contrast, nodal FDG SUV was not predictive. Primary tumor FDG SUV is a promising prognostic factor and may establish the need for intensified locoregional therapy in individual patients. Multiinstitutional imaging trials and further characterization of the biology responsible for elevated FDG uptake in HNSCC will be necessary to confirm the prognostic utility of FDG-labeled PET.

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“…Inspite of advances in surgical and other treatments that enhance quality of life and moderating pain, survival rates are not improving for this type of cancer [5], [6]. There has been no significant improvement in 5-year survival over the past 20 years, despite aggressive and multidisciplinary treatment approaches [7], [8], [9]. Research on Molecular biology has provided us with large number of biomarkers that can provide information related to prognosis, treatment options, recurrence and development of secondary primary tumor [10].…”

Section: Introductionmentioning

confidence: 99%

CTIP2 Expression in Human Head and Neck Squamous Cell Carcinoma Is Linked to Poorly Differentiated Tumor Status

et al. 2009

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BackgroundWe have demonstrated earlier that CTIP2 is highly expressed in mouse skin during embryogenesis and in adulthood. CTIP2 mutant mice die at birth with epidermal differentiation defects and a compromised epidermal permeability barrier suggesting its role in skin development and/or homeostasis. CTIP2 has also been suggested to function as tumor suppressor in cells, and several reports have described a link between chromosomal rearrangements of CTIP2 and human T cell acute lymphoblast leukemia (T-ALL). The aim of the present study was to look into the pattern of CTIP2 expression in Head and Neck Squamous Cell Carcinoma (HNSCC).Methodology/Principal FindingsIn the present study, we analyzed CTIP2 expression in human HNSCC cell lines by western blotting, in paraffin embedded archival specimens by immunohistochemistry (IHC), and in cDNA samples of human HNSCC by qRT-PCR. Elevated levels of CTIP2 protein was detected in several HNSCC cell lines. CTIP2 staining was mainly detected in the basal layer of the head and neck normal epithelium. CTIP2 expression was found to be significantly elevated in HNSCC (p<0.01), and increase in CTIP2 expression was associated with poorly differentiated tumor status. Nuclear co-localization of CTIP2 protein and cancer stem cell (CSC) marker BMI1 was observed in most, if not all of the cells expressing BMI1 in moderately and poorly differentiated tumors.Conclusions/SignificanceWe report for the first time expression of transcriptional regulator CTIP2 in normal human head and neck epithelia. A statistically significant increase in the expression of CTIP2 was detected in the poorly differentiated samples of the human head and neck tumors. Actual CTIP2, rather than the long form of CTIP2 (CTIP2L) was found to be more relevant to the differentiation state of the tumors. Results demonstrated existence of distinct subsets of cancer cells, which express CTIP2 and underscores the use of CTIP2 and BMI1 co-labeling to distinguish tumor initiating cells or cancer stem cells (CSCs) from surrounding cancer cells.

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The Use of Genetic Markers in the Clinical Care of Patients With Head and Neck Cancer

Cited by 12 publications

References 22 publications

Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

FDG-PET Prediction of Head and Neck Squamous Cell Cancer Outcomes

CTIP2 Expression in Human Head and Neck Squamous Cell Carcinoma Is Linked to Poorly Differentiated Tumor Status

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