Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

Siriwardena, B. S. M. S.; Kudo, Yasusei; Ogawa, Ikuko; Kitagawa, Masae; Kitajima, Shojiro; Hatano, Hiroko; Tilakaratne, W. M.; Miyauchi, Mutsumi; Takata, Takashi

doi:10.1038/sj.bjc.6603431

Cited by 144 publications

(139 citation statements)

References 26 publications

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“…Previous studies showed that periostin was up-regulated in various types of cancers such as the lung, 26 brain, 8 ovary, 9 breast, 27 colon 11 and oral cavity, 28,29 and its serum level was reported to be high in patients with thymoma, 30 non-small cell lung cancer 10 and breast cancer. 31 These reports suggested that periostin is involved in tumor spread, invasion and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells

Kanno

Satoh

Masamune

et al. 2008

Intl Journal of Cancer

121

103

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Periostin is a secretory protein that has been suggested to function as a cell adhesion molecule and promote the invasiveness or growth rate of tumors. However, little is known about the association of its expression and epithelial to mesenchymal transition (EMT), which is considered to play a crucial role in cancer cell metastasis. Thus, the authors investigated whether periostin could be involved in the process of EMT and the role of this gene in pancreatic cancer development. The expression of periostin was observed mainly in stromal cells but very little in cancer cells by immunohistochemistry and real-time RT-PCR. In vitro, pancreatic stellate cells (PSCs) exhibited a much higher basal expression of periostin compared with cancer cells. Periostin secreted in the supernatant from 293T cells that expressed periostin (approximately 150 ng/ml) inhibited the migration of pancreatic cancer cells. Coculture assay revealed that periostin expression in PSC was induced by pancreatic cancer cells. To assess the direct role of periostin in pancreatic cancer cells, the authors generated pancreatic cancer cell lines that stably express periostin. The induced expression of periostin (to 150 ng/ml) altered the morphology of cancer cells, changing them from mesenchymal to epithelial phenotypes with the induction of epithelial markers and a reduction of mesenchymal markers, and showed reduced cell migration in vitro and formed smaller tumors as well as suppressed metastasis in vivo. On the other hand, high concentration of recombinant periostin (1 lg/ml) promoted cell migration with AKT activation. The findings suggest that periostin has biphasic effect on the development of pancreatic cancer. ' 2008 Wiley-Liss, Inc.Key words: pancreatic cancer; periostin; EMT; pancreatic stellate cell Pancreatic adenocarcinoma is one of the most malignant gastrointestinal tumors. Once pancreatic cancer is clinically evident, it progresses rapidly to develop metastatic lesions, frequently by the time of diagnosis. The pathogenic mechanisms that regulate the aggressive behavior of this cancer still remain to be clarified.Tumor metastasis is a multistep pathological process involved in the final phase of tumor development. During this process, epithelium-derived tumor cells undergo fibroblast-like transformation, referred to as epithelial-mesenchymal transition (EMT). 1,2 EMT is the process by which an epithelial cell shows transitory changes in cell structure and becomes a more motile mesenchymal cell with migratory properties during embryogenesis. This transition is considered to be an important event during malignant tumor progression and metastasis. [3][4][5] Periostin is a secretory protein that has been suggested to function as a cell adhesion molecule for preosteoblasts and to participate in osteoblast recruitment, attachment and spreading. 6,7 Recently, the expression of periostin has been implicated in the development of variety of carcinomas such as neuroblastoma, 8 epithelial ovarian cancer 9 and non-small cell lung carcinoma. 10 P...

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Section: Discussionmentioning

confidence: 99%

Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells

Kanno

Satoh

Masamune

et al. 2008

Intl Journal of Cancer

121

103

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“…It has been shown by serial analysis of gene expression (SAGE) and multiple genome-wide microarrays that human periostin gene is overexpressed in several human tumors including carcinomas of ovary, breast, pancreas and head and neck squamous cell carcinoma (26)(27)(28)(29)(30). On the other hand, acquired expression of periostin by cancer cells greatly promotes metastatic development, adhesion and invasion of cancer cell lines (7,8,12,13,15). Cumulative findings suggest that high expression of periostin might be a common event in tumor development.…”

Section: Discussionmentioning

confidence: 99%

“…Whereas integrin expression level is supposed to be related to metastasis, relapse and prognosis of CRC (10,11). In addition, expression of periostin is reported to be elevated in certain malignant tumors including head and neck cancer (12,13), nasopharyngeal carcinoma (14), breast cancer (15)(16)(17), CRC (7), and pancreatic carcinoma (9,18). Circulating levels of periostin was found to be elevated in thymoma, breast cancer with bone metastases, and pancreatic carcinoma (9,(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Circulating levels of periostin may help identify patients with more aggressive colorectal cancer

Ben

Zhao²,

Ge³

et al. 2009

Int J Oncol

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Abstract. Elevated levels of periostin have been implicated as playing important roles in tumor invasion and metastasis in various tissues. Thus, we determined whether serum periostin levels were associated with progression and poor prognosis in colorectal cancer (CRC) patients. We measured serum periostin levels by ELISA in 67 CRC patients and 120 controls. We also evaluated periostin expression in human CRC specimens (n=15) using immunohistochemistry, and measured expression of periostin mRNA in 7 CRC tissue samples, matched normal tissues and in 4 colon cancer cell lines by RT-PCR. We analyzed the relationship between serum levels of periostin and other clinicopathologic characteristics in patients with CRC. The serum levels of periostin in CRC patients (40.9±15.4 ng/ml) were significantly elevated compared to that in healthy volunteers (21.0±7.3 ng/ml, P<0.0001) and benign colorectal polyps or adenomas (22.4±8.5 ng/ml, P<0.0001). Higher preoperative serum levels of periostin in CRC were found to correlate with distant metastasis (P=0.003), advanced-stage disease (stage III/IV, P<0.0001) and poor prognosis. Preoperative serum periostin levels of 15 cases were significantly higher than matched postoperative levels (47.2±13.5 ng/ml vs. 31.3±11.0 ng/ml, P=0.008). Twelve of 15 patients (80%) had positive immunohistochemical periostin staining in CRC samples. Interestingly, periostin mRNA was highly upregulated in CRCs in comparison with matched normal tissues, and no expression of periostin mRNA was detected in 4 colon cancer cell lines. Serum levels of periostin detected by ELISA may be of clinical value in identifying patients who may be at high risk for aggression and metastasis of CRC. Periostin may be produced by the stromal cells surrounding the tumor, but not by the CRC cells themselves.

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“…Also, PN is reported to be up-regulated in the metastases of colorectal and liver cancers, suggesting its role in promoting tumor growth. Increased expression of PN has been associated with advanced carcinogenesis and cell proliferation, adhesion and migration (6)(7)(8). PN expression was readily detectable in breast tumor samples, while it was undetectable in normal breast tissue (9).…”

Section: Introductionmentioning

confidence: 96%

Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model

Kyutoku

Taniyama

Katsuragi³

et al. 2011

Int J Mol Med

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Abstract. Periostin (PN), a secreted adhesion-related protein expressed in the periosteum and periodontal ligaments, acts as a critical regulator of the formation and maintenance of bone and teeth, and also plays an important role in tumorigenesis. Although PN is highly expressed in various types of human cancers, its function is still unclear. In this study, we focused on the exon 17 region of PN, which is alternatively spliced out. To investigate the function of full-length PN with exon 17, we produced a neutralizing antibody (PN1-Ab) against the peptide encoded by exon 17. In vivo, administration of PN1-Ab significantly inhibited the growth of primary tumors as well as metastatic tumors, associated with prevention of bone destruction, resulting in increased survival of mice. consistent with in vivo data, the present in vitro study demonstrated that addition of full-length PN significantly inhibited cell adhesion and detached adherent cells, while PN1-Ab inhibited the action of PN in a dose-dependent manner. In addition, PN1-Ab significantly inhibited the proliferation, migration and invasion of 4T1 mouse breast cancer cells, which produced PN. Interestingly, PN1-Ab also inhibited the differentiation of osteoclasts. Overall, the present study demonstrated that PN plays a pivotal role in the progression and metastasis of breast cancer. Since administration of PN1-Ab prolonged cell survival through inhibition of the progression and metastasis of 4T1 cells, further development of the PN1-Ab such as generation of a humanized antibody may provide a new therapeutic agent against breast cancer.

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Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

Cited by 144 publications

References 26 publications

Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells

Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells

Circulating levels of periostin may help identify patients with more aggressive colorectal cancer

Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model

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