The Use of Gelatin Foam Sponges in Obstetrics and Gynecology

Barnes, Allan C.

doi:10.1016/s0002-9378(16)39476-5

Cited by 16 publications

(13 citation statements)

References 3 publications

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“…Animal studies have revealed that these gelatin sponges assist in the healing process following renal surgeries without any marked inflammatory or foreign–body response. A review of chemically crosslinked gelatin sponges in gynecologic surgeries has also reported no palpable formation of excessive scar tissue postoperatively . More recently, they have also been successfully and safely used in humans as graft materials in oral surgery and in neurosurgical procedures …”

Section: Discussionmentioning

confidence: 99%

Novel in situ liquefying antimicrobial wrap for preventing tissue expander infections following breast reconstructive surgeries

et al. 2015

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Breast reconstruction surgeries using tissue expanders (TEs) have highly reported infection rates. To decrease this, we developed a method for disinfecting TEs and surgical pockets, where an antimicrobial solution was applied as a solid film at implantation that subsequently liquefied in situ to provide extended prophylaxis. Silicone discs cut from TEs were covered with gelatin-based films containing minocycline (M) and rifampin (R). Discs and films soaked in saline were subsequently challenged with pathogen at days 1, 3, 7, and 10 and quantified for potential biofilm formation. Discs that were not harvested at each specific time points were refreshed with sterile saline. The discs were challenged with clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), and multidrug-resistant Pseudomonas aeruginosa (MDR-PA). Recoveries of adherent organisms from uncovered silicone discs and gelatin-wrapped discs without added antimicrobial agents were >5 × 10(4) CFU/disc for each organism at each time point. Experimental 0.1%M/0.05%R gelatin films completely inhibited all challenge organisms from attaching to the silicone (p < 0.05) at each time point through day 10. Cytotoxicity was assessed by incubating films with HEK-293T human fibroblasts. There were no significant differences in HEK-293T cell survival between controls and any of the antimicrobial films. The in situ liquefying, bioabsorable, antimicrobial wrap prevented biofilm formation by microorganisms on silicone surfaces in vitro with minimal cytotoxicity.

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Section: Discussionmentioning

confidence: 99%

Novel in situ liquefying antimicrobial wrap for preventing tissue expander infections following breast reconstructive surgeries

et al. 2015

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“…Soaking it in triamcinolone acetonide, it is likely to be resorbed 21 within 4e6 weeks of placement with minimal scarring and foreign body reaction. 22 Within this period (4e6 week after placement) healing will take place in the joint region with the establishment of pseudo-joint in place of temporomandibular joint.…”

Section: Discussionmentioning

confidence: 99%

Retrospective study of absorbable gelatin sponge soaked in triamicinolone acetonide as interpositioning material in temporomandibular joint ankylosis in 350 patients

Pal

Singh

Malkunje

et al. 2013

Journal of Oral Biology and Craniofacial Research

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“…Its surface essentially acts in the intrinsic pathway causing contact activation involving platelets and therefore it has hemostatic activity. Gelfoam is gradually absorbed by phagocytosis and usually absorbed in approximately from 4 to 6 weeks [15]. Several trials have suggested that Gelfoam are biocompatible [11] and, in addition, Gelfoam packing has been long used in surgery of chronic otitis media without any complications.…”

Section: Discussionmentioning

confidence: 99%

Comparison between Gelfoam packing and no packing after endoscopic sinus surgery in the same patients

Wee

Lee

Rhee

et al. 2011

Eur Arch Otorhinolaryngol

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After functional endoscopic sinus surgery (FESS), nasal packing may be necessary and a packing material which has benefits in both cost and efficacy would be required. This study aimed to determine the efficacy of Gelfoam packing on hemostasis and wound healing after FESS. Patients who underwent bilateral FESS due to chronic bilateral rhinosinusitis were enrolled. Randomly, one side was selected for Gelfoam packing and the other side for no packing. Subjective symptoms and objective findings such as synechia, granulation, pus discharge, edema, stenosis, and crust were evaluated. A total of 21 patients (17 men and 4 women; mean age 39.7 years ranging from 12 to 75 years) were included. There were no statistical significant differences between two groups regarding both subjective symptoms and objective findings during 4 months after surgery. Three patients had postoperative bleeding in the no packing side. Gelfoam packing may be recommendable in terms of efficacy and cost-benefit after FESS.

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The Use of Gelatin Foam Sponges in Obstetrics and Gynecology

Cited by 16 publications

References 3 publications

Novel in situ liquefying antimicrobial wrap for preventing tissue expander infections following breast reconstructive surgeries

Novel in situ liquefying antimicrobial wrap for preventing tissue expander infections following breast reconstructive surgeries

Retrospective study of absorbable gelatin sponge soaked in triamicinolone acetonide as interpositioning material in temporomandibular joint ankylosis in 350 patients

Comparison between Gelfoam packing and no packing after endoscopic sinus surgery in the same patients

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