The use of Gamma Knife stereotactic radiosurgery in the treatment of ameloblastic carcinoma

Perera, Esther; Lindquist, Christer; Hughes, C.; Thomas, Steven

doi:10.1016/j.ijom.2013.04.015

Cited by 14 publications

(14 citation statements)

References 6 publications

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“…Chemotherapy has not been indicated as a primary treatment (16). Patients with secondary tumors exhibit a higher rate of recurrence and metastasis and to date, chemotherapy has shown no favorable results for local control (23). In addition, few chemotherapy reports are available and its role is yet to be confirmed (24).…”

Section: Discussionmentioning

confidence: 99%

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Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature

Peng

et al. 2014

Oncology Letters

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The diagnosis of ameloblastic carcinoma is often difficult and the optimal treatment methods remain controversial. The current study retrospectively investigated the optimal diagnosis and treatment methods of 12 ameloblastic carcinoma patients at the West China Hospital of Stomatology, Sichuan University (Chengdu, China), and 20 patients selected from the PubMed database, were reviewed. The clinical features, diagnosis and outcome of the different treatments were evaluated. Ameloblastic carcinoma occurred in 12 out of a total of 538 ameloblastoma patients; the majority were of the primary type. Of the 538 ameloblastoma patients, 294 were male, 244 were female with a male to female ratio of 1.2:1. The predilection age is 20–30 years, which accounts for 40% of the total. In total, 461 cases were in the mandible and 77 were located in the maxilla. The cure rate of the primary type and the recurrence rate of the secondary type tumors were higher in the patients from the West China Hospital of Stomatology compared with those reported in the literature. In particular, a case with a long-term survival of 30 years is presented, which is considered to be relatively rare. The evolution of the clinical course has experienced three stages: Ameloblastoma (1978) followed by metastatic ameloblastoma (2000) and finally ameloblastic carcinoma (2008). To avoid recurrence, wide local excision with postoperative radiation therapy is required. While novel therapeutic regimens should also be considered as appropriate, including carbon ion therapy and Gamma Knife stereotactic radiosurgery. However, controlled studies with larger groups of patients are required to increase the accuracy of results.

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Section: Discussionmentioning

confidence: 99%

“…In addition, compared with the conventional radiotherapy, carbon ion therapy exhibits less severe complications. Perera et al (23) considered Gamma Knife stereotactic radiosurgery as a promising option for instances where tumors present in surgically complex regions.…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature

Peng

et al. 2014

Oncology Letters

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“…A general consensus on treatment modalities for AC has still not been reached; however, surgical therapy is the most widely used treatment option, while few data regarding chemotherapy are available (34). The recurrence rate following curettage of maxillary ameloblastoma is almost 100% (25); Yoon et al (29) reported a recurrence rate of 92.3% following curettage alone and 28.3% following partial resection, and therefore a wide surgical resection, with clear margins free of tumor, is recommended (5,28,34).…”

Section: Discussionmentioning

confidence: 99%

“…The recurrence rate following curettage of maxillary ameloblastoma is almost 100% (25); Yoon et al (29) reported a recurrence rate of 92.3% following curettage alone and 28.3% following partial resection, and therefore a wide surgical resection, with clear margins free of tumor, is recommended (5,28,34). Taking into consideration the relatively lower malignancy of primary AC, a more tissue sparing resection may be indicated for primary tumors, while a wider resection is recommended in cases of secondary AC (6,28).…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic carcinoma of the maxilla: A case report and an updated review of the literature

et al. 2016

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Ameloblastic carcinoma (AC) is an uncommon malignant odontogenic tumor that can be difficult to differentiate from ameloblastoma and can arise directly as an undifferentiated lesion or from a pre-existing benign lesion. The current study presents a novel case of primary maxillary AC and review the literature on AC of the maxilla. The review of the literature indicates that secondary tumors and posterior localization are associated with a higher tendency for recurrence and, often, multiple recurrences. Surgical therapy, eventually followed by radiotherapy, is the treatment modality most frequently applied, while the role of chemotherapy remains unclear. Several new cases of maxillary AC have been recently described in literature, making this pathology more frequent than previously considered; this is perhaps an indication of an increased diagnostic sensibility, rather than a real increase in the incidence of the disease itself.

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“…En oncologie ORL, les techniques modernes de radiothérapie semblent également apporter des solutions thérapeutiques là où il n'y avait pas d'alternative. Perera et al ont notamment rapporté un cas de récidive locale d'un carcinome améloblas-tique de la mandibule, cancer rare dont la prévalence en Europe est de 0,1/100 000 habitants [22], dont le traitement par radiothérapie stéréotaxique (GammaKnife © ) a offert une possibilité thérapeutique locale [23]. Dans les localisations ORL, les techniques de stéréotaxie permettent une nette réduction de la toxicité salivaire, et cela d'autant plus que les doses sont élevées.…”

Section: Cancers Rares Traités Avec De Nouvelles Techniques De Radiotunclassified