Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature

Abstract

The diagnosis of ameloblastic carcinoma is often difficult and the optimal treatment methods remain controversial. The current study retrospectively investigated the optimal diagnosis and treatment methods of 12 ameloblastic carcinoma patients at the West China Hospital of Stomatology, Sichuan University (Chengdu, China), and 20 patients selected from the PubMed database, were reviewed. The clinical features, diagnosis and outcome of the different treatments were evaluated. Ameloblastic carcinoma occurred in 12 out of a total of 538 ameloblastoma patients; the majority were of the primary type. Of the 538 ameloblastoma patients, 294 were male, 244 were female with a male to female ratio of 1.2:1. The predilection age is 20–30 years, which accounts for 40% of the total. In total, 461 cases were in the mandible and 77 were located in the maxilla. The cure rate of the primary type and the recurrence rate of the secondary type tumors were higher in the patients from the West China Hospital of Stomatology compared with those reported in the literature. In particular, a case with a long-term survival of 30 years is presented, which is considered to be relatively rare. The evolution of the clinical course has experienced three stages: Ameloblastoma (1978) followed by metastatic ameloblastoma (2000) and finally ameloblastic carcinoma (2008). To avoid recurrence, wide local excision with postoperative radiation therapy is required. While novel therapeutic regimens should also be considered as appropriate, including carbon ion therapy and Gamma Knife stereotactic radiosurgery. However, controlled studies with larger groups of patients are required to increase the accuracy of results.

Ameloblastic carcinoma of the maxilla: A rare case presentation and a review of new cases

“…In the present study, we assessed 17 newly reported cases of maxillary AC from 2009 to 2017 (see Table 1). [2,6,[8][9][10][11][12][13] The age ranges from 21 to 77 years (mean age: 57.1 years) and the male to female ratio was 7.5:1, which was consistent with the Kruse et al report. [3] Most of the lesions (88.2%) similar to the present case and to previously reported cases occurred in the posterior portion of the maxilla.…”

“…[3] Most of the lesions (88.2%) similar to the present case and to previously reported cases occurred in the posterior portion of the maxilla. [7,8,11] Clinically, swelling was the first clinical symptom in 94.1% of cases. Bleeding, pain, trismus and ulceration were associated with swelling in 47.05% of cases.…”

Spindle cell variant of ameloblastic carcinoma: a case report and literature review

“…The effectiveness of radiation therapy in the treatment of ameloblastic carcinoma is controversial, with some reports favoring it 19 and others doubting its efficacy. 20 One study, in particular, used radiation therapy as adjuvant treatment for spindle cell variant of ameloblastic carcinoma and reported good prognosis.…”

Ameloblastoma: 25 Year Experience at a Single Institution

“…While neglected and recurrent ameloblastoma can cause significant morbidity, mortality is extremely rare and is seen typically in a setting of maxillary ameloblastoma extending into the cranium [2,14,15]. The rare metastasizing ameloblastoma and ameloblastic carcinoma, each described in up to 2 % of patients with ameloblastoma, can also infrequently lead to mortality [2,4,5,8,21].…”