Spindle cell variant of ameloblastic carcinoma: a case report and literature review

Fujita, Shuichi; Yanamoto, Souichi; Yamada, Shin‐ichi; Rokutanda, Satoshi; Yamashita, Kentaro; Ikeda, Tohru; Umeda, Masahiro

doi:10.1016/j.oooo.2015.06.034

Cited by 21 publications

(8 citation statements)

References 23 publications

(22 reference statements)

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“…[12][13][14] The positive expression of CK19 in the tumor epithelium in this study supports an odontogenic origin, and was also used to identify the nature of the spindle cells, which provides evidence for the diagnosis of odontogenic carcinosarcoma. [13][14][15] Some studies have found that CK8 and/or CK18 expression is more common in head and neck malignant tumors, especially in poorly differentiated tumors, which is consistent with this case. [14][15][16] The strong positive Ki-67 and Bcl-2 expression indicated that both epithelial and mesenchymal cells proliferated actively.…”

Section: Discussionsupporting

confidence: 89%

“…[13][14][15] Some studies have found that CK8 and/or CK18 expression is more common in head and neck malignant tumors, especially in poorly differentiated tumors, which is consistent with this case. [14][15][16] The strong positive Ki-67 and Bcl-2 expression indicated that both epithelial and mesenchymal cells proliferated actively. EGFR can regulate the migration and invasion of human ameloblastoma cells and the secretion of matrix metalloproteinases, and promote the local invasion of ameloblastoma.…”

Section: Discussionsupporting

confidence: 89%

“…Positively p63 expression in tumor epithelial cells suggested that the epithelial cells had two malignant manifestations of low differentiation and high growth potential. [15][16][17][18] The mesenchymal marker, vimentin was expressed in both mesenchymal and epithelial cells, and the positive E-cadherin expression in interstitial cells was low, indicating that the adhesion capacity of interstitial spindle cells was reduced. Additionally, the presence of epithelial cells in the tumor indicated an interstitial transformation phenomenon.…”

Section: Discussionmentioning

confidence: 99%

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Odontogenic carcinosarcoma with dentinoid: a rare case report

et al. 2021

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Odontogenic carcinosarcoma is a very rare malignant odontogenic tumor, characterized by malignant epithelial and mesenchymal components. Studies have reported several cases of odontogenic carcinosarcoma, mainly in the upper and lower jaws, with malignant clinical manifestations. Herein, we present the case of a 58-year-old woman with odontogenic carcinosarcoma with dentinoid in the left maxilla. The invasion range was large, and the left maxillary molar was missing. Histology revealed odontogenic carcinosarcoma with bidirectional differentiation characteristics and comprising three components: malignant epithelium, malignant interstitium, and dentinoid. The patient subsequently underwent nasal endoscopic sinus tumor resection, and she recovered well after surgery. After a strict 4-year follow-up, to date, there are still no signs of disease or local recurrence. To our knowledge, this is the first reported case of odontogenic carcinosarcoma with dentinoid. Our study describes the clinical, morphological, and immunohistochemical characteristics of this case, and distinguishes it from related diseases.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Odontogenic carcinosarcoma with dentinoid: a rare case report

et al. 2021

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“…[7,10] Owing to the small number of cases, elective radical neck dissection is still under review but radical neck dissection for tumors with evidence of positive cervical lymph nodes is recommended. [8,15] To date, few chemotherapy reports for local control are also available that revealed no significant advantages for AC patients. Due to high recurrence rate and pulmonary metastasis, long term follow-up and CT or MRI controls are essential.…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic carcinoma of the maxilla: A rare case presentation and a review of new cases

Sargolzaei

Khaleghjoo

Taghavi

2017

JST

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“…The exclusion criteria were conference abstracts, reviews, and articles with unavailable full text. Eighteen full-length studies were extracted for inclusion, and clinical and radiographic features of AC were recorded (1,(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

Section: Literature Review Of Acmentioning

confidence: 99%

Reconstruction of soft tissue defect after maxillectomy of ameloblastic carcinoma with submental island flap: a case report and literature review

Xu¹,

Shang²,

Yang³

et al. 2021

Ann Transl Med

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Ameloblastic carcinoma (AC) is an extremely rare malignant odontogenic tumor. The mean age of occurrence for all 141 AC cases analyzed in our systematic review study was 43.59±19.51 years.Males were more affected than females, and the mandible was predominantly affected compared with the maxilla. The main clinical manifestation was a painful or painless swelling with ulceration and radiographic features usually displayed as mixed cystic or solid changes. Surgical resection was the first recommended method of management. Fourteen cases had cervical lymph node spread, 19 had distant metastasis (most commonly in the lung), and 33 had recurrence. We present a rare case of AC involving the maxillary region. Locally extensive surgical resection was carried out. Ablative defects after maxillectomy resulted in the communication of oral cavity and nasal cavity/maxillary antrum and would bring about difficulties in mastication, deglutition, and speech. A submental island flap was applied to close the oronasal and oroantral fistula. The flap and the wounds healed well, with excellent outcomes in terms of appearance, the function of speech, and swallowing on follow up. The submental island flap provides a relatively thin, easy-to-harvest, and well-vascularized tissue, which makes it a reliable option in soft tissue reconstruction of the oral and maxillofacial region.

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Spindle cell variant of ameloblastic carcinoma: a case report and literature review

Cited by 21 publications

References 23 publications

Odontogenic carcinosarcoma with dentinoid: a rare case report

Odontogenic carcinosarcoma with dentinoid: a rare case report

Ameloblastic carcinoma of the maxilla: A rare case presentation and a review of new cases

Reconstruction of soft tissue defect after maxillectomy of ameloblastic carcinoma with submental island flap: a case report and literature review

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