The Use of Gadolinium Orthovanadate Nanoparticles for the Correction of Reproductive Ability in Boars Under Oxidative Stress

Abstract

The search for effec ve and safe means for correc ng male hypofer lity is an urgent problem of modern reproductology. Researchers have proved the possibility of the use of nanopar cles based on oxides of rare-earth elements for the treatment of disorders of male reproduc ve func on. We inves gated the effec veness of the use of gadolinium orthovanadate nanopar cles ac vated by europium, the size of which was 25×8 nm in the dose of 0.0125 mg per kg of live weight to correct reproduc ve ability decrease in boars under oxida ve stress. A er 14 days of hydrosol nanopar cles administra on, we experimentally established the dynamics of the content of oxida ve stress markers and stable metabolites in the nitrogen oxide cycle, and also determined the changes in sperm quality indicators. Thus, conjugated dienes concentra on in the blood serum of boars on the 15th day tended to decrease, and on the 30th day of the study was lower by 9.4% compared with the group of animals before administra on. At the same me, the amount of thiobarbituric acid reac ve substances decreased on the 15th day of the study by 24.7%, and the 30th day -by 48.2%, which indicates the normaliza on of oxida ve processes in males. We noted posi ve changes in the system