Effectiveness of using the complex drug ‘Karafand+OV,Zn’ to increase the reproductive capacity of males of domestic animals

Abstract

Experimental research on male domestic animals (boars, bulls) proved the effectiveness of using the complex drug ‘Karafand+OV,Zn’ to increase their reproductive capacity. This preparation contains carotenoids, biologically active substances from the rhizome of marsh calamus and nanoparticles of orthovanadate gadolinium activated by europium and zinc carbonate. It was observed that the introduction of the drug increased the activity of antioxidant protection — catalase activity in the serum and erythrocytes in boars by 15.9% (p < 0.01) and 11.4% (p < 0.05), in bulls — by 7.3% (p < 0.05) and 12.4% (p < 0.01), respectively, and SOD in boars by 30.2% (p < 0.01), in bulls — by 16.5% (P <0.05) — when reducing the intensity of lipoperoxidation processes (reducing the amount of TBA-AP in the serum and erythrocytes of males — in boars by 19.4% (p < 0.05) and 16.9% (p < 0.001), in bulls — by 25% (p < 0.05) and by 12.4% (p < 0.01), respectively. There was an improvement in sperm quality (especially in terms of motility and content of sperm with morphological abnormalities) and endocrine function of the testes — testosterone levels increased by 16.8% in boars (p < 0.05), and in bulls — by 44.3 % (p < 0.001). At the same time, there was an increase in protein-vitamin-mineral metabolism in the body: the amount of vitamin A reliably increased in boars by 14.5% (p < 0.001), in bulls — by 7.6% (p < 0.05), and the content of zinc — in boars by 36.5% (p < 0.001), in bulls — by 16.0% (p < 0.01), the amount of total protein, calcium and phosphorus also increased. Thus, the obtained results allow us to recommend the complex drug ‘Karafand+OV,Zn’ as an effective means for increasing the reproductive capacity of males with pronounced sperm-modeling and androgen-stimulating effects and powerful antioxidant properties