The Use of Flow Chemistry in the Multicomponent Synthesis of Heterocycles

Lambruschini, Chiara; Moni, Lisa; Basso, Andrea

doi:10.1002/9783527832439.ch6

Cited by 1 publication

(1 citation statement)

References 39 publications

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“…[3][4][5] In general, complex structures can be easily formed from inexpensive and simple starting materials by these transformations. [6][7][8][9] In addition, these properties make them suitable to create large libraries of structurally-related compounds. [10][11][12] MCRs especially show their importance in the synthesis of heterocycles.…”

Section: Introductionmentioning

confidence: 99%

Multicomponent Synthesis of Potentially Biologically Active Heterocycles Containing a Phosphonate or a Phosphine Oxide Moiety

Popovics-Tóth

Bálint

2022

ACSi

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Several multicomponent synthetic approaches were elaborated for plenty of novel nitrogen or oxygen heterocycles containing a phosphonate or a phosphine oxide moiety. All multicomponent reactions were optimized through a model reaction in respect of the heating mode, molar ratio of the starting materials, atmosphere, catalyst, temperature, reaction time and solvent applied, and then, the extended preparation of small libraries of structurally-related compounds was performed. Most of the reactions could be considered as “green syntheses”, as they were carried out in the absence of any catalyst and/or solvent using microwave (MW) irradiation or even at ambient temperature. The scaling-up of a MW-assisted synthesis was also elaborated in a continuous flow MW system. Altogether more than 150 heterocyclic organophosphorus compounds were synthesized, among them several derivatives showed moderate or promising activity against the HL-60 cell line and Bacillus subtilis bacteria.

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