We
employed oleylphosphonic acid (OLPA) for the synthesis of CsPbBr
3
nanocrystals (NCs). Compared to phosphonic acids with linear
alkyl chains, OLPA features a higher solubility in apolar solvents,
allowing us to work at lower synthesis temperatures (100 °C),
which in turn offer a good control over the NCs size. This can be
reduced down to 5.0 nm, giving access to the strong quantum confinement
regime. OLPA-based NCs form stable colloidal solutions at very low
concentrations (∼1 nM), even when exposed to air. Such stability
stems from the high solubility of OLPA in apolar solvents, which enables
these molecules to reversibly bind/unbind to/from the NCs, preventing
the NCs aggregation/precipitation. Small NCs feature efficient, blue-shifted
emission and an ultraslow emission kinetics at cryogenic temperature,
in striking difference to the fast decay of larger particles, suggesting
that size-related exciton structure and/or trapping-detrapping dynamics
determine the thermal equilibrium between coexisting radiative processes.
In addition to inhibiting the cyclooxygenasemediated biosynthesis of prostanoids, various widely used non-steroidal anti-inflammatory drugs (NSAIDs) enhance endocannabinoid signaling by blocking the anandamidedegrading membrane enzyme, fatty acid amide hydrolase (FAAH). The X-ray structure of FAAH in complex with the NSAID carprofen, along with studies of site-directed mutagenesis, enzyme activity assays, and nuclear magnetic resonance, now reveal the molecular details of this interaction, providing information that may guide the design of dual FAAH-cyclooxygenase inhibitors with superior analgesic efficacy.
Experiments and simulations reveal that amphiphilic nanoparticles suppress phase separation in neuronal-like lipid bilayers and form bilayer-embedded ordered aggregates.
This perspective aims at celebrating the 100th Anniversary of the discovery of the Passerini three component reaction. After being nearly neglected for many years, now this reaction has become quite...
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