The Use of Fibrin Glue in the Treatment of Fistula-In-Ano: A Prospective Study

Maralcan, Göktürk; Baskonus, Hacı Mehmet; Aybastı, Necdet; Gökalp, Avni

doi:10.1007/s00595-005-3121-5

Cited by 42 publications

(27 citation statements)

References 15 publications

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“…Venkatesh and Ramanujam 88 suggested that recurrence was higher in tracts of shorter length. These findings were supported by the failure of fibrin glue in fistula tracts of 2.5 cm 93 and recurrence rates of 54% and 11% for fistula tracts 3.5 cm and >3.5 cm in length, respectively. 89 The failure of fibrin glue in short fistula tracts was suggested to be due to the 10-second solidification period of the glue being too long to prevent the leakage of the semisolid glue out of the small tract.…”

Section: Biological Gluessupporting

confidence: 69%

Perianal fistulae in Crohnʼs Disease: Current and future approaches to treatment

Keshaw¹,

Foong²,

Forbes³

et al. 2010

Inflammatory Bowel Diseases

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: affecting sphincter integrity and continence. Traditional surgical and medical approaches are not without their limitations and may result in either comorbidity, such as fecal incontinence, or incomplete healing of the fistulae. Over the last 2 decades these limitations have led to a paradigm shift toward the use of biomaterials, and more recently cell-based therapies, which have met with variable degrees of success. This review discusses the traditional and current methods of treatment, as well as emerging and possible alternative approaches that may improve fistula healing.

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Section: Biological Gluessupporting

confidence: 69%

Perianal fistulae in Crohnʼs Disease: Current and future approaches to treatment

Keshaw¹,

Foong²,

Forbes³

et al. 2010

Inflammatory Bowel Diseases

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“…Different studies like Maralcan et al 12 and Chan et al 13 also noted increased incidence of fistula in ano in males (5:1 and 9:1 respectively).…”

Section: Table 3 Comparison Of Pain Between the Two Groupsmentioning

confidence: 83%

Outcomes of Lift Versus Seton in Complex Fistula-in-Ano- A Comparative Study

Gupta¹,

Sharma²,

Singla³

et al. 2018

jebmh

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BACKGROUNDA fistula-in-ano is an abnormal tract or cavity establishing a communication between rectum or anal canal and the perianal area. Surgery is the treatment of choice with the goals of draining infection, eradicating the fistulous tract and avoiding persistent or recurrent disease while preserving anal sphincter function. Various surgical options available include fistulotomy/fistulectomy with seton wire placement, advanced flaps, fistula plugs, fibrin glue and more recently newer techniques such as Ligation of the intersphincteric fistula tract (LIFT), Video-assisted anal fistula treatment (VAAFT) and FILAC technique (Fistula-Tract Laser Closure).The present study was conducted to assess and compare the outcome of LIFT procedure and Seton wire placement in complex fistula-in-ano.

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“…Fibrin glue has been used for surgical sealants since the 1940s, and since then has been applied for the treatment of anal fistulas (18 that the main benefit of this approach is that it does not provoke incontinence.…”

Section: Discussionmentioning

confidence: 99%

Method for Management of Perianal Fistula with New Device: Progressive Curettage of the Tract and Sealing with Platelet-Rich Fibrin

Lara¹,

Berges²,

González³

et al. 2016

Ann Colorectal Res

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Surgical treatment of high perianal fistulas, which affect a significant proportion of the sphincter apparatus, is difficult and associated with considerable risk of impaired anal continence. The diversity of approaches proposed for the treatment of complex perianal fistulas reflects the fact that no method has yet been shown to be fully satisfactory. We believe the successful treatment of this condition is directly proportional to the amount of fibrous tissue that can be removed. We used a kit of small curettes, of different thicknesses and sizes, incorporating spicules that enable the physician to remove fibrous tissue from the fistula tract. The small size and varying thicknesses of the curettes enable them to mold to the curves of the fistula tract and to remove tissue by de-roofing from the shallowest to the deepest layers, thus excising the entire fibrous tract. The tract is then sealed using autologous fibrin, applied through a catheter, with the help of a monitor indicating the amount of product remaining at all times. Finally, the internal orifice is closed by simple suturing.

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The Use of Fibrin Glue in the Treatment of Fistula-In-Ano: A Prospective Study

Cited by 42 publications

References 15 publications

Perianal fistulae in Crohnʼs Disease: Current and future approaches to treatment

Perianal fistulae in Crohnʼs Disease: Current and future approaches to treatment

Outcomes of Lift Versus Seton in Complex Fistula-in-Ano- A Comparative Study

Method for Management of Perianal Fistula with New Device: Progressive Curettage of the Tract and Sealing with Platelet-Rich Fibrin

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