The use of EEG in the diagnosis of dementia with Lewy bodies

Roks, Gerwin; Korf, Esther S.C.; Flier, Wiesje M. van der; Scheltens, Philip; Stam, Cornelis J.

doi:10.1136/jnnp.2007.125385

Cited by 80 publications

(64 citation statements)

References 24 publications

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“…The more frequent demonstration of both focal and diffuse EEG abnormalities in DLB and VaD compared to AD is in agreement with previous studies [12,14,18,19] , although 1 study found focal abnormalities not sufficiently prevalent to distinguish VaD from AD [13] . Two studies failed to distinguish DLB from AD by visually scoring predominantly diffuse EEG disturbances on a 4-point scale [15,16] , which is probably less sensitive than the visual interpretation of an EEG pattern, which includes the scoring of both diffuse and focal abnormalities.…”

Section: Discussionsupporting

confidence: 92%

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Associations between Patterns of EEG Abnormalities and Diagnosis in a Large Memory Clinic Cohort

Liedorp¹,

Flier²,

Hoogervorst³

et al. 2008

Dement Geriatr Cogn Disord

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Aim: To describe associations of abnormalities in the electroencephalogram (EEG) with the most prevalent diagnoses in a memory clinic cohort. Methods: Associations between visual EEG findings and diagnoses in 1,116 consecutive patients [382 Alzheimer’s disease (AD), 274 subjective complaints, 190 mild cognitive impairment (MCI), 118 psychiatric disorder, 61 frontotemporal lobar degeneration, 53 vascular dementia (VaD), 38 dementia with Lewy bodies (DLB)] were determined by prevalence ratio (PR). Results: Diagnoses of subjective complaints [PR = 1.6; 95% confidence interval (CI) = 1.4–1.9] and psychiatric disorder (1.4; 95% CI = 1.1–1.9) were associated with a normal EEG, while subjects with both focal and diffuse EEG disturbances were more likely to have DLB (3.5; 95% CI = 2.1–5.6), VaD (2.3; 95% CI = 1.4–3.6) or AD (1.5; 95% CI = 1.3–1.8). Subjects with only diffuse EEG abnormalities were more likely to have AD (PR = 1.5; 95% CI = 1.3–1.9). The prevalence of MCI was higher among those with only focal EEG abnormalities (PR = 1.3; 95% CI = 1.0–1.7). Conclusions: A normal EEG argues for subjective complaints or psychiatric diagnosis. An EEG with only focal abnormalities supports MCI. An EEG with only diffuse abnormalities argues for AD. An EEG with both focal and diffuse abnormalities argues for DLB, VaD or AD.

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Section: Discussionsupporting

confidence: 92%

“…Three cohort studies of DLB patients (n = 10-18) did not include 1 patient with a visually rated normal EEG [14,17,18] , which support our findings. The prevalence of a normal EEG in VaD has previously been reported to be either the same or lower than in AD [12,13] .…”

Section: Discussionsupporting

confidence: 76%

Associations between Patterns of EEG Abnormalities and Diagnosis in a Large Memory Clinic Cohort

Liedorp¹,

Flier²,

Hoogervorst³

et al. 2008

Dement Geriatr Cogn Disord

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“…It is also of great importance to verify whether EEG helps to distinguish between AD and other dementias; in the last years, studies have investigated whether EEG alone allows to differentiate between AD, subjective memory complaints [116,173,175], psychiatric disorders [173], vascular dementia [173,176,177,178,179,180], fronto-temporal dementia [116,173,180], dementia with Lewy bodies [173,181,182], dementia with Parkinson's disease [182], and vascular dementia with Alzheimer's disease [60]. The preliminary results are generally promising, but surely, additional investigations will be required to explore the potential of EEG for differential diagnosis of dementia, and brain disorders at large.…”

Section: Differential Diagnosis Of Dementiamentioning

confidence: 99%

Diagnosis of Alzheimers Disease from EEG Signals: Where Are We Standing?

Dauwels¹,

Vialatte²,

Cichocki³

2010

CAR

379

188

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This paper reviews recent progress in the diagnosis of Alzheimer's disease (AD) from electroencephalograms (EEG). Three major effects of AD on EEG have been observed: slowing of the EEG, reduced complexity of the EEG signals, and perturbations in EEG synchrony. In recent years, a variety of sophisticated computational approaches has been proposed to detect those subtle perturbations in the EEG of AD patients. The paper first describes methods that try to detect slowing of the EEG. Next the paper deals with several measures for EEG complexity, and explains how those measures have been used to study fluctuations in EEG complexity in AD patients. Then various measures of EEG synchrony are considered in the context of AD diagnosis.Also the issue of EEG pre-processing is briefly addressed. Before one can analyze EEG, it is necessary to remove artifacts due to for example head and eye movement or interference from electronic equipment. Pre-processing of EEG has in recent years received much attention. In this paper, several state-of-the-art pre-processing techniques are outlined, for example, based on blind source separation and other non-linear filtering paradigms.In addition, the paper outlines opportunities and limitations of computational approaches for diagnosing AD based on EEG. At last, future challenges and open problems are discussed.

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“…Roks és mtsai DLB-ben lassabb hát-téraktivitást, diffúzabb lassúhullám-tevékenységet, csök-kent reaktivitást és magasabb proximális aktivitást detektáltak az AD-hez képest. Feltételezik, hogy a kifejezettebb EEG-változások hátterében a súlyosabb kolinergdeficit állhat [60].…”

Section: Elektroencefalográfia (Eeg) éS Liquor-biomarkerekunclassified

A Lewy-testes demencia klinikai és neuropatológiai jellemzői

et al. 2017

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A Lewy-testes demencia a második leggyakoribb neurodegeneratív demencia. A pontos diagnózisa gyakran csak neuropatológiai vizsgálattal lehetséges. A betegség fő morfológiai jellemzője a kóros α-szinukleinben gazdag Lewy-test és Lewy-neurit -csakúgy, mint a rokon kórkép Parkinson-kór és az ahhoz társuló demencia esetén. A patomechanizmus fontos tényezői a neurotranszmitter rendszerek zavara, a szinaptikus diszfunkció és az ubikvitin-proteaszóma rendszer elégtelen működése. Jellemző a kognitív teljesítmény fluktuációja, parkinsonizmus és vizuális hallucináció. Mivel gyakran nem típusos a klinikai kép és időbeni lefolyás, a képalkotó eljárások és biomarkerek elősegíthetik a korai felismerést. Noha hatékony oki terápia nincs, életminőséget javító kezelések lehetségesek. A klinikopatológiai vizsgálatok kiemelten fontosak a patomechanizmus jobb megértése, a pontos diagnózis és a hatékony terápia érdeké-ben. Orv Hetil. 2017; 158(17): 643-652.Kulcsszavak: Lewy-testes demencia, neuropatológia, biomarkerek, Parkinson-kór, α-szinuklein Clinical and neuropathological characteristics of dementia with Lewy bodiesDementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. The accurate diagnosis is often possible only by neuropathological examination. The morphologic hallmarks are the presence of α-synuclein-rich Lewy bodies and Lewy neurites, identical to those seen in Parkinson's disease (PD) and Parkinson's disease dementia (PDD). Neurotransmitter deficits, synaptic and ubiquitin-proteasome system (UPS) dysfunction play major role in the pathomechanism. Characteristic symptoms are cognitive fluctuation, parkinsonism and visual hallucinations. Due to the often atypical clinical presentation novel imaging techniques and biomarkers could help the early diagnosis. Although curative treatment is not available, therapies can improve quality of life. Clinicopathological studies are important in exploring pathomechanisms, ensuring accurate diagnosis and identifying therapeutic targets.

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The use of EEG in the diagnosis of dementia with Lewy bodies

Cited by 80 publications

References 24 publications

Associations between Patterns of EEG Abnormalities and Diagnosis in a Large Memory Clinic Cohort

Associations between Patterns of EEG Abnormalities and Diagnosis in a Large Memory Clinic Cohort

Diagnosis of Alzheimers Disease from EEG Signals: Where Are We Standing?

A Lewy-testes demencia klinikai és neuropatológiai jellemzői

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