The Use of Dry Oxidized Cellulose as a Primary Hemostatic Agent in Neurosurgery

Scarff, John E.; Stookey, Byron; Garcı́a, Francisco

doi:10.3171/jns.1949.6.4.0304

Cited by 21 publications

(6 citation statements)

References 6 publications

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“…Finally, ORC products have satisfactory tissue compatibility due to their pH lowering effect on solutions 22,23 and a low potential for promoting foreign body reaction. 24 Their acidic properties provide a bactericidal environment, reducing the incidence of infections associated with ORC. [25][26][27] We only observed a few cases of pneumonia in association with THT, which were probably due to the inability of mucus clearing behind the obstructed airway, rather than a propagated infection as a result of foreign tissue reaction.…”

Section: Discussionmentioning

confidence: 99%

Bronchoscopy-Guided Topical Hemostatic Tamponade Therapy for the Management of Life-Threatening Hemoptysis

Valipour

Kreuzer

Koller

et al. 2005

Chest

128

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Section: Discussionmentioning

confidence: 99%

Bronchoscopy-Guided Topical Hemostatic Tamponade Therapy for the Management of Life-Threatening Hemoptysis

Valipour

Kreuzer

Koller

et al. 2005

Chest

128

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“…15,17 Oxidized cellulose (Oxycel; Ethicon, Inc., Johnson & Johnson, Inc., New Brunswick, NJ) and oxidized regenerated cellulose (Surgicel; Ethicon, Inc., Johnson & Johnson, Inc.) are also used frequently. 3,27 Despite early studies documenting the biocompatibility of oxidized cellulose, 13 granulomatous reactions to it that mimick infection or tumor recurrence have been reported. 5,16 Microfibrillar collagen (Avitene; C. R. Bard, Inc., Murray Hills, NJ), which not only exerts a local matrix-forming effect to induce hemostasis but actively promotes coagulation and platelet aggregation, 1 is also used in neurosurgical practice.…”

mentioning

confidence: 98%

Foreign body reaction to hemostatic materials mimicking recurrent brain tumor

Kothbauer¹,

Jallo²,

Siffert³

et al. 2001

Journal of Neurosurgery

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Chemical agents routinely used in neurosurgery to achieve intraoperative hemostasis can cause a foreign body reaction, which appears on magnetic resonance (MR) images to be indistinguishable from recurrent tumor. Clinical and/or imaging evidence of progression of disease early after surgical resection or during aggressive treatment may actually be distinct features of granuloma in these circumstances. A series of three cases was retrospectively analyzed for clinical, imaging, surgical, and pathological findings, and the consequences they held for further disease management. All patients were boys (3, 3, and 6 years of age, respectively) and all harbored primitive neuroectodermal tumors. Two tumors were located in the posterior fossa and one was located in the right parietal lobe. Two boys exhibited clinical symptoms, which were unexpected under the circumstances and prompted new imaging studies. One patient was asymptomatic and imaging was performed at planned routine time intervals. The MR images revealed circumscribed, streaky enhancement in the resection cavity that was suggestive of recurrent disease. This occurred 2 to 7 months after the first surgery. At repeated surgery, the resected material had the macroscopic appearance of gelatin sponge in one case and firm scar tissue in the other cases. Histological analysis revealed foreign body granulomas in the resected material, with Gelfoam or Surgicel as the underlying cause. No recurrent tumor was found and the second surgery resulted in imaging-confirmed complete resection in all three patients. Because recurrent disease was absent, the patients continued to participate in their original treatment protocols. All patients remain free from disease 34, 32, and 19 months after the first operation, respectively. During or after treatment for a central nervous system neoplasm, if unexpected clinical or imaging evidence of recurrence is found, a second-look operation may be necessary to determine the true nature of the findings. If the resection yields recurrent tumor, additional appropriate oncological treatment is warranted, but if a foreign body reaction is found, potentially harmful therapy can be withheld or postponed.

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“…Surgical ligation was utilized sparingly for fear of vessel rupture or vascular occlusion that may compromise entire vascular distributions. The instruments and techniques in neurosurgical armamentarium therefore relied predominately on application of pressure with gauze to combat bleeding [3,6]. As a result, a search and incorporation of novel alternatives in hemostatic techniques would effectively lead to the development of modern neurosurgery as represented by Horsley's use of bone wax and other pioneering hemostatic maneuvers [7,8] and the introduction of electrosurgery by Cushing and Bovie in the 1920's [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…As a result, a search and incorporation of novel alternatives in hemostatic techniques would effectively lead to the development of modern neurosurgery as represented by Horsley's use of bone wax and other pioneering hemostatic maneuvers [7,8] and the introduction of electrosurgery by Cushing and Bovie in the 1920's [9,10]. Later in the revolutionary era of neurosurgery, biosurgical materials were introduced [6,11].…”

Section: Introductionmentioning

confidence: 99%

Biosurgical Materials in Neurosurgical Applications: From Pioneers to Leaders

Petit-Me¹,

Stawicki²,

Firstenberg³

et al. 2021

Contemporary Applications of Biologic Hemostatic Agents Across Surgical Specialties [Working Title]

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Hemostasis in neurosurgery has evolved significantly over the past few decades. New advances in hemostatic agents, some developed specifically with neurosurgical applications in mind, allowed for more effective control of difficult intraoperative bleeding. These agents vary in the mechanism of action and each may be indicated in different and often highly specific situations. Here we present a review of the most commonly used hemostatic agents, their mechanism of action and their indications. Focus is placed on key aspects and considerations regarding the use biosurgical materials in neurosurgery, with emphasis on clinical appropriateness and patient safety.

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The Use of Dry Oxidized Cellulose as a Primary Hemostatic Agent in Neurosurgery

Cited by 21 publications

References 6 publications

Bronchoscopy-Guided Topical Hemostatic Tamponade Therapy for the Management of Life-Threatening Hemoptysis

Bronchoscopy-Guided Topical Hemostatic Tamponade Therapy for the Management of Life-Threatening Hemoptysis

Foreign body reaction to hemostatic materials mimicking recurrent brain tumor

Biosurgical Materials in Neurosurgical Applications: From Pioneers to Leaders

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