The Use Of Demineralized Freeze-dried Bovine Bone Xenograft In Reducing Post-surgical Periodontal Recession

Abstract

favorable because it does not completely restore the architecture or function of the lost tissues. On the other hand, regeneration includes reproduction of the lost or injured parts but reconstitutes only a very small portion, only the base of the pocket. Furthermore, regeneration of PDL and alveolar bone is a slower process compared to repair by LJE. Regeneration of the alveolar bone lost through periodontal disease remains one of the biggest challenges in dentistry. Various efforts have been made to achieve regeneration using the principles of Guided Tissue Regeneration, Guided Bone Regeneration or the use of bone graft. However, bone graft has gained popularity as GTR and GBR were shown to be technique sensitive and highly expensive. The objectives of periodontal bone graft are to reduce periodontal pocket depth, to achieve gain in clinical attachment level (CAL), to achieve bone fill of the osseous defects and to regenerate new bone, cementum and PDL. Since bone graft functions as a scaffold, it should prevent the apical migration of the soft tissue therefore preventing or minimizing recession. Clinical human and animal studies can provide valuable information on the first 3 objectives and the last objective requires histological analysis for verification. Historically, autogenous graft is the gold standard in periodontal therapy as it has proven to have regenerative potential. However, recent histological studies have revealed that demineralized freeze-dried bovine bone xenograft (DFDBBX) has regenerative potential as well (1). The DFDBBX was reported to be biocompatible, has osteoconductive potential (2) and its physical properties were similar to human bone mineral in inner surface area,

The effect of combined Moringa oleifera and demineralized freeze-dried bovine bone xenograft on the amount of osteoblast and osteoclast in the healing of tooth extraction socket of Cavia cobaya

“…25 Xenograft also has an ability to regenerate tissue osteoconductively because it has inner surface properties, porosity, calcium ratio, and mineral factors, such as hydroxyapatite owned by bovine similar to human bone minerals. 26 DFDBBX plays a role as osteo conductor in osteoinduction. 27 But, inorganic materials derived from this graft can make the attachment and proliferation of osteoblast cells as the first step for the formation of osteoblasts to form bone.…”