The use of DBD plasma treatment and polymerization for the enhancement of biomedical UHMWPE

Cools, Pieter; Vrekhem, Stijn Van; Geyter, Nathalie De; Morent, Rino

doi:10.1016/j.tsf.2014.08.033

Cited by 47 publications

(32 citation statements)

References 34 publications

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“…In spite of its excellent chemical properties, UHMWPE is an inert and non-polar material, which makes it difficult to bind adhesively. Previous studies have aimed at and succeeded at increasing this adhesion by using plasma technology 4 , 5 . In these studies, plasma activation and plasma polymerization of methyl methacrylate (MMA) were performed in a dielectric barrier discharge (DBD)-reactor in order to alter the surface chemistry of UHMWPE samples resulting in an improved adhesion between bone cement and UHMWPE or in case of uncemented press-fit fixation an enhanced interaction between osteoblasts and UHMWPE.…”

Section: Introductionmentioning

confidence: 99%

Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet

Vrekhem

Vloebergh

Asadian

et al. 2018

Sci Rep

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Insufficient glenoid fixation is one of the main reasons for failure in total shoulder arthroplasty. This is predominantly caused by the inert nature of the ultra-high molecular weight polyethylene (UHMWPE) used in the glenoid component of the implant, which makes it difficult to adhesively bind to bone cement or bone. Previous studies have shown that this adhesion can be ameliorated by changing the surface chemistry using plasma technology. An atmospheric pressure plasma jet is used to treat UHMWPE substrates and to modify their surface chemistry. The modifications are investigated using several surface analysis techniques. The adhesion with bone cement is assessed using pull-out tests while osteoblast adhesion and proliferation is also tested making use of several cell viability assays. Additionally, the treated samples are put in simulated body fluid and the resulting calcium phosphate (CaP) deposition is evaluated as a measure of the in vitro bioactivity of the samples. The results show that the plasma modifications result in incorporation of oxygen in the surface, which leads to a significant improved adhesion to bone cement, an enhanced osteoblast proliferation and a more pronounced CaP deposition. The plasma-treated surfaces are therefore promising to act as a shoulder implant.

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Section: Introductionmentioning

confidence: 99%

Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet

Vrekhem

Vloebergh

Asadian

et al. 2018

Sci Rep

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“…The radicals absorb or react with the previously activated surface, condense, and polymerize on the substrate creating a thin film coating (Goodman 1960, Williams 1966, Yasuda 1985, Kushner 1987, Hegemann 2006. Plasma-deposited polymers have been extensively studied in the biomedical field for anti-fouling applications (Nisol 2014), to improve biocompatibility, to tailor the physic-chemical properties of the substrates (Yoshida, 2013), to enhance cell/surface or tuneable biomolecule/surface interactions, for tissue engineering applications (Bhatt 2015), for the modification (Cools, 2014) and the patterning (Favia 2003, Sardella 2004, Sardella 2005 of biomedical surfaces or in the design of novel drug delivery systems (Vasilev, 2011, Bhatt 2013, Labay 2015, Canal 2016.…”

Section: Introductionmentioning

confidence: 99%

Modulation of release kinetics by plasma polymerization of ampicillin-loaded β-TCP ceramics

Labay¹,

Buxadera‐Palomero²,

Avilés³

et al. 2016

J. Phys. D: Appl. Phys.

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Beta-tricalcium phosphate (β-TCP) bioceramics are employed in bone repair surgery. Their local implantation in bone defects puts them in the limelight as potential materials for local drug delivery. However, obtaining suitable release patterns fitting the required therapeutics is a challenge. Here, plasma polymerization of ampicillin-loaded β-TCP is studied for the design of a novel antibiotic delivery system. Polyethylene glycol-like (PEG-like) coating of β-TCP by low pressure plasma polymerization was performed using Diglyme as precursor, and nanometric PEG-like layers were obtained by simple and double plasma polymerization processes. Significant increase in hydrophobicity, and the presence of plasma polymer was visible on the surface by SEM and quantified by XPS. As main consequence of the plasma polymerisation, the release kinetics was successfully modified, avoiding burst release, and slowing down the initial rate of release leading to a 4.5 hours delay in reaching the same antibiotic release percentage, whilst conservation of the activity of the antibiotic was simultaneously maintained. Thus, plasma polymerisation on the surface of bioceramics may be a good strategy to design controlled drug delivery matrices for local bone therapies.

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“…A detailed description of the atmospheric pressure DBD plasma set-up used in this work can be found in previous work [37]. In summary, the parallel-plate DBD reactor consists of 2 copper electrodes (55 mm diameter), which are both covered with a glass plate resulting in an inter-electrode distance of 3 mm.…”

Section: 3experimental Set-upmentioning

confidence: 99%

Adhesion improvement at the PMMA bone cement-titanium implant interface using methyl methacrylate atmospheric pressure plasma polymerization

Cools

Vanderleyden

Barberis

et al. 2016

Surface and Coatings Technology

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The use of DBD plasma treatment and polymerization for the enhancement of biomedical UHMWPE

Cited by 47 publications

References 34 publications

Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet

Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet

Modulation of release kinetics by plasma polymerization of ampicillin-loaded β-TCP ceramics

Adhesion improvement at the PMMA bone cement-titanium implant interface using methyl methacrylate atmospheric pressure plasma polymerization

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