The use of coenzyme Q0 as a template in the development of a molecularly imprinted polymer for the selective recognition of coenzyme Q10

Contin, Mario; Flor, Sabrina; Martinefski, Manuela; Lucangioli, Silvia; Trípodi, Valeria

doi:10.1016/j.aca.2013.11.030

Cited by 23 publications

(16 citation statements)

References 25 publications

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“…It should be taken into account that the increase of the amount of monomer and cross‐linker could enhance the imprinting factor, IF . Accordingly, different ratios of monomer and cross‐linker were investigated to study their effect on enhancing the selectivity.…”

Section: Resultsmentioning

confidence: 99%

Computational Design, Synthesis and Application of a New Selective Molecularly Imprinted Polymer for Electrochemical Detection

et al. 2016

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A computational approach was developed to find a suitable functional monomer to design a new molecularly imprinted polymer (MIP), based on which methacyrlic acid (MAA) was selected as a functional monomer to synthesize the molecular imprinted and non‐imprinted polymers. All calculations were carried out using Gaussian 03 software based on the application of Hartree−Fock (HF) method with 6‐31G (d) basis set. The performance of the MIPs prepared with different ratios of MAA was then evaluated using equilibrium rebinding assays. The MIP with the highest binding capacity was chosen as recognition material for the fabrication of new PVC sensors and their responses were compared with each other and with previously reported modifiers in literature. The addition of the ionic surfactant (TFPB) was found to have a synergistic effect on the response mechanism of the electrodes. The results of the MIP modified sensors show that they provide an improved electrode slope, wider pH range and a highly extended life time reaching 7 months compared to 2–4 weeks in case of traditional ion‐exchangers reported in literature, besides, being successfully applied for measurements in biological samples.

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Section: Resultsmentioning

confidence: 99%

Computational Design, Synthesis and Application of a New Selective Molecularly Imprinted Polymer for Electrochemical Detection

et al. 2016

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“…The use of molecularly imprinted polymers (MIPs) can overcome these drawbacks [8,9]. MIPs are synthetic receptors that are prepared by copolymerizing functional monomers with crosslinker monomers in the presence of a particular template molecule [10]. After removal of this target, cavities are obtained with a high affinity and selectivity for the corresponding template molecule [11].…”

Section: Introductionmentioning

confidence: 99%

Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers

Wackers

Vandenryt

Cornelis

et al. 2014

Sensors

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In this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. Therefore, the MIP array sensor platform with HTM as a readout technique, has the potential to become a low-cost analysis tool for bioanalytical applications.

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“…Después de la optimización, se seleccionó una relación de 2:8 entre monómero más reticulante y porógeno. Este resultado estuvo en concordancia con los datos obtenidos en trabajos previos [144,145]. Además, el BPO representó el 1% del peso total del monómero utilizado.…”

Section: Síntesis Del Polímerounclassified

A simple and highly selective molecular imprinting polymer-based methodology for propylparaben monitoring in personal care products and industrial waste waters

Vicario

Aragón²,

Wang

et al. 2018

Journal of Pharmaceutical and Biomedical Analysis

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In this work, a novel molecularly imprinted polymer (MIP) proposed as solid phase extraction sorbent was developed for the determination of propylparaben (PP) in diverse cosmetic samples. The use of parabens (PAs) is authorized by regulatory agencies as microbiological preservative; however, recently several studies claim that large-scale use of these preservatives can be a potential health risk and harmful to the environment. Diverse factors that influence on polymer synthesis were studied, including template, functional monomer, porogen and crosslinker used. Morphological characterization of the MIP was performed using SEM and BET analysis. Parameters affecting the molecularly imprinted solid phase extraction (MISPE) and elution efficiency of PP were evaluated. After sample clean-up, the analyte was analyzed by high performance liquid chromatography (HPLC). The whole procedure was validated, showing satisfactory analytical parameters. After applying the MISPE methodology, the extraction recoveries were always better than 86.15%; the obtained precision expressed as RSD% was always lower than 2.19 for the corrected peak areas. Good linear relationship was obtained within the range 8-500ngmL of PP, r=0.99985. Lower limits of detection and quantification after MISPE procedure of 2.4 and 8ngmL, respectively were reached, in comparison with previously reported methodologies. The development of MISPE-HPLC methodology provided a simple an economic way for accomplishing a clean-up/preconcentration step and the subsequent determination of PP in a complex matrix. The performance of the proposed method was compared against C-18 and silica solid phase extraction (SPE) cartridges. The recovery factors obtained after applying extraction methods were 96.6, 64.8 and 0.79 for MISPE, C18-SPE and silica-SPE procedures, respectively. The proposed methodology improves the retention capability of SPE material plus robustness and possibility of reutilization, enabling it to be used for PP routine monitoring in diverse personal care products (PCP) and environmental samples.

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The use of coenzyme Q0 as a template in the development of a molecularly imprinted polymer for the selective recognition of coenzyme Q10

Cited by 23 publications

References 25 publications

Computational Design, Synthesis and Application of a New Selective Molecularly Imprinted Polymer for Electrochemical Detection

Computational Design, Synthesis and Application of a New Selective Molecularly Imprinted Polymer for Electrochemical Detection

Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers

A simple and highly selective molecular imprinting polymer-based methodology for propylparaben monitoring in personal care products and industrial waste waters

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