The use of chitosan as cationic coating or gel vehicle for polymeric nanocapsules: Increasing penetration and adhesion of imiquimod in vaginal tissue

Frank, Luíza Abrahão; Chaves, Paula dos Santos; D'Amore, Camilo Marques; Contri, Renata Vidor; Frank, Alejandro Germán; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin; Buffon, Andréia; Guterres, Sílvia Stanisçuaski

doi:10.1016/j.ejpb.2017.01.021

Cited by 78 publications

(42 citation statements)

References 38 publications

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“…Furthermore, in general the nanocapsules coated with HMW chitosan showed a slightly higher mean diameter than those coated with LMW chitosan (p>0.05), probably as a consequence of the chitosan higher molecular weight and higher viscosity in the water phase. In general, it has been reported that the higher is the viscosity of the dispersion medium, the higher is the mean diameter of nanoparticles produced [57]. Table 1.…”

Section: Characterization Of Nanocapsulesmentioning

confidence: 98%

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

Bruinsmann¹,

Pigana²,

Aguirre³

et al. 2019

Preprint

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Drug delivery to the brain represents a challenge especially in the therapy of central nervous system malignancies. Simvastatin (SVT), as other statins, has shown potential anticancer properties that are difficult to exploit in the CNS. In the present work the physico-chemical, mucoadhesive and permeability enhancing properties of simvastatin-loaded poly-ε-caprolactone nanocapsules coated with chitosan for nose-to-brain administration were investigated. Lipid-core nanocapsules coated with different molecular weight (MW) chitosans (LNCchit) prepared by a novel one-pot technique were characterized for particle size, surface charge, particle number density, morphology, drug encapsulation efficiency, interaction between surface nanocapsules with mucin, drug release and permeability across two nasal mucosa models. Results show that all formulations present adequate particle size (below 220 nm), positive surface charge, narrow droplet size distribution (PDI<0.2) and high encapsulation efficiency. Nanocapsules presented controlled drug release and mucoadhesive properties dependent on the MW of the coating chitosan. The results of permeation across RPMI 2650 human nasal cell line evidenced that LNCchit increased the permeation of SVT. In particular, the amount of SVT permeated after 4h for nanocapsules coated with low MW chitosan, high MW chitosan and control SVT was 13.91 ± 0.78 µg, 9.15 ± 1.23 µg and 1.42 ± 0.21 µg respectively. These results were confirmed by the SVT ex vivo permeation across rabbit nasal mucosa. This study highlighted the suitability of LNCchit as promising strategy for the administration of simvastatin for a nose-to-brain approach for the therapy of brain tumors.

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Section: Characterization Of Nanocapsulesmentioning

confidence: 98%

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

Bruinsmann¹,

Pigana²,

Aguirre³

et al. 2019

Preprint

Self Cite

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show abstract

“…Mucoadhesion studies reveal that the NPs interact with the ocular mucosa [93]. Imiquimod was formulated as both chitosan coated PCL nanocapsules embedded in hydroethylcellulose gel and PCL nanocapsules embedded in chitosan hydrogel for vaginal delivery to treat human papillomavirus infection [94]. The former was found to show higher mucoadhesion while the latter has shown high drug permeation.…”

Section: Mucoadhesionmentioning

confidence: 99%

“…The former was found to show higher mucoadhesion while the latter has shown high drug permeation. Balancing the considerations of mucoadhesion, permeation and drug retention, the latter was selected as the best delivery system [94]. …”

Section: Mucoadhesionmentioning

confidence: 99%

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

et al. 2017

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The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration. Chitosan has chemical functional groups that can be modified to achieve specific goals, making it a polymer with a tremendous range of potential applications. Nanoparticles (NP) prepared with chitosan and chitosan derivatives typically possess a positive surface charge and mucoadhesive properties such that can adhere to mucus membranes and release the drug payload in a sustained release manner. Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review. Chitosan shows low toxicity both in vitro and some in vivo models. This review explores recent research on chitosan based NP for non-parenteral drug delivery, chitosan properties, modification, toxicity, pharmacokinetics and preclinical studies.

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“…It is hypothesized that the combined use of these two strategies results in a better performance of the formulation to retain imiquimod into the vaginal tissue. Thus, when considered the integrative indexes for the formulations, our results show that chitosan based nanocarrier presents the best performance for the treatment of HPV [9].…”

Section: Coating or Gel Vehicle For Drug Deliverymentioning

confidence: 81%

Commentary on the Development and Application of Chitosan in Immunochemistry

Liu¹,

Gan²,

Long³

2017

Immunochem Immunopathol

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The use of chitosan as cationic coating or gel vehicle for polymeric nanocapsules: Increasing penetration and adhesion of imiquimod in vaginal tissue

Cited by 78 publications

References 38 publications

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

Commentary on the Development and Application of Chitosan in Immunochemistry

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