The Use of Calcium Sulfate as a Bone Substitute

Oh, Chang Wug; Kyung, Hee-Soo; Kim, Poong Taek; Park, Il Hyung; Kim, Do Heon

doi:10.4055/jkoa.1998.33.7.1859

Cited by 3 publications

(8 citation statements)

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“…Calcium sulfate has been generally regarded as bio-compatible [10,28,31,32]. However, many previous studies have also indicated that calcium sulfate lacks osteoinductivity [10,[32][33][34][35][36]. The present study demonstrates two important characteristics that support the bioactivity of a (Ca,Sr)SO 4 specimen.…”

Section: Bioactivity Of (Casr)sosupporting

confidence: 63%

Transformation from calcium sulfate to calcium phosphate in biological environment

Chen

Tuan

Lai

2021

J Mater Sci: Mater Med

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The formation of a nano-apatite surface layer is frequently considered a measure of bioactivity, especially for non-phosphate bioceramics. In the present study, strontium-doped calcium sulfate, (Ca,Sr)SO4, was used to verify the feasibility of this measure. The (Ca,Sr)SO4 specimen was prepared by mixing 10% SrSO4 by weight with 90% CaSO4·½H2O powder by weight. A solid solution of (Ca,7.6%Sr)SO4 was then produced by heating the powder mixture at 1100 °C for 1 h. The resulting (Ca,Sr)SO4 specimen was readily degradable in phosphate solution. A newly formed surface layer in the form of flakes was formed within one day of specimen immersion in phosphate solution. Structural and microstructure–compositional analyses indicated that the flakes were composed of octacalcium phosphate (OCP) crystals. An amorphous interface containing OCP nanocrystals was found between the newly formed surface layer and the remaining (Ca,Sr)SO4 specimen. The specimen was also implanted into a rat distal femur bone defect. In addition to new bone, fibrous tissue and inflammatory cells were found to interlace the (Ca,Sr)SO4 specimen. The present study indicated that a more comprehensive evaluation is needed to assess the bioactivity of non-phosphate bioceramics.

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Section: Bioactivity Of (Casr)sosupporting

confidence: 63%

Transformation from calcium sulfate to calcium phosphate in biological environment

Chen

Tuan

Lai

2021

J Mater Sci: Mater Med

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“…In the aspect of biocompatibility, those unknown glass‐liked particles are assumed to be silica, unwanted substance. Accordingly, in the present study, we have selected pure plaster of Paris which has been used as a filling material for bone defect 15–17. In the use of plaster of Paris, the accuracy of 3D fabrication is uncertain.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of freeform bone‐filling calcium phosphate ceramics by gypsum 3D printing method

et al. 2009

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Transformation of gypsum model fabricated by three-dimensional printing (3DP) into hydroxyapatite (HA) by treating in ammonium phosphate solution is possible. However, 3DP powder supplied by the manufacturer contains unknown additives which may be questionable for biomaterials. Accordingly, pure plaster of Paris (POP) powder was used for fabrication in the present study. For accurate fabrication, reduction of supplied binder ink to 80% of standard amount for 3DP powder supplied by the manufacturer was found to be the optimal condition for POP fabrication. Transformation from POP to HA was done by immersing into 1 mol/L ammonium phosphate solution. However, preheating of fabricated POP specimen at 200 degrees C for 30 min to change from calcium sulfate dihydrate into calcium sulfate hemihydrate could accelerate the transformation into HA effectively. To increase compressive strength, HA transformed specimen was sintering at 1150 degrees C for 3 h. The compressive strength increased four times comparing with as transformed HA specimen. However, crystal structure was transformed to beta-TCP due to the chemical reaction between the transformed HA and remained phosphate from ammonium phosphate solution at the sintering temperature. A sophisticated application of the present 3DP method to fabricate the freeform bioceramic for osseous defect was attempted, and jaw bone defect filling biomaterial of beta-TCP and scaffold with macroporous structures could be fabricated. Present 3DP method has possibility to fabricate freeform bioceramic for osseous defect or scaffold.

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“…The calcium sulfate bone void fillers had been successfully used to treat trauma at femur or tibia, osteomyelitis at humerus, and enchondroma at phalanx 1–7 . Apart from calcium sulfate, other ingredients, such as calcium phosphates, calcium carbonate, or their composites, 6,8–10 had also been used as bone void filler.…”

Section: Introductionmentioning

confidence: 99%

“…Calcium sulfate is therefore widely used for its fast absorption rate. However, the absorption rate of calcium sulfate is much faster than the rate of new bone formation 2,13 . For example, Oh et al 2 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microstructure design for bone void filler

Tuan

Chen

Hsu

et al. 2022

Int J Applied Ceramic Tech

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Bone void fillers are used to fill in the empty space within bone defect. The use of fillers is aiming to reduce the time required for healing the defect. The filler should show the resistance to washout and the ability of adsorption within human body. In the present study, a microstructure design approach is employed to evaluate the performance of bone void filler. The microstructure features, such as the contacts between particles, the size of pores, and their interconnectivity, are considered. The pellets composing of these microstructure features are prepared for in vitro and in vivo evaluations. The type of contacts between resorbable particles plays a key role on washout resistance. The interconnectivity of pores affects significantly on the absorption rate in vivo. Through the control of these microstructure characteristics, the resorbable behavior of bone void filler can be tailored.

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The Use of Calcium Sulfate as a Bone Substitute

Cited by 3 publications

References 0 publications

Transformation from calcium sulfate to calcium phosphate in biological environment

Transformation from calcium sulfate to calcium phosphate in biological environment

Fabrication of freeform bone‐filling calcium phosphate ceramics by gypsum 3D printing method

Microstructure design for bone void filler

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