The use of Brazilian propolis for discovery and development of novel anti-inflammatory drugs

Franchin, Marcelo; Freires, Irlan Almeida; Lazarini, Josy Goldoni; Nani, Bruno Dias; Cunha, Marcos Guilherme da; Colón, David F.; Alencar, Severino Matias de; Rosalen, Pedro Luiz

doi:10.1016/j.ejmech.2017.06.050

Cited by 97 publications

(70 citation statements)

References 59 publications

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“…Media such as milk should not be considered as “physiological” because ankylosis may occur when avulsed teeth are placed in milk, and concern has also been raised over its sterility and temperature . Propolis has been applied medically because of its antimicrobial, anti‐inflammatory, and antioxidant properties . One study has shown that avulsed teeth stored in a medium containing antioxidants might improve the outcome of replantation .…”

Section: Discussionmentioning

confidence: 99%

Effect of propolis on preserving human periodontal ligament cells and regulating pro‐inflammatory cytokines

Yuan

Wang

Shi

et al. 2018

Dental Traumatology

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Section: Discussionmentioning

confidence: 99%

Effect of propolis on preserving human periodontal ligament cells and regulating pro‐inflammatory cytokines

Yuan

Wang

Shi

et al. 2018

Dental Traumatology

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“…In particular, propolis has an anti-inflammatory effect, which can prevent atherosclerosis, reduce blood lipids, affect angiogenesis, and play an important role in the prevention and treatment of cardiovascular diseases [ 18 ]. Previous studies have shown that propolis could inhibit inflammation by inhibiting inflammatory cytokines (TNF-α, IL-1β, and IL-6), the ERK1/MAPK pathway, NF-κB activation, and neutrophil adhesion and transmigration (ICAM-1, VCAM-1 and E-selectin expression) [ 19 ]. Propolis extract could also effectively inhibit the levels of total cholesterol (TC), triglyceride (TG), non-high-density lipoprotein cholesterol (non-HDL-C), and the production of IL-6 and IL-17 in ApoE−/−mice fed a high-fat diet to protect vascular endothelial cells [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

The Chemical Composition of Brazilian Green Propolis and Its Protective Effects on Mouse Aortic Endothelial Cells against Inflammatory Injury

Yang

Wang

et al. 2020

Molecules

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Propolis has a very complex composition, with antibacterial, anti-inflammatory and other properties. To determine the composition of ethanol extracts of Brazilian green propolis (EEP-B) and their protective effect on mouse aortic endothelial cells (MAECs), the chemical composition of EEP-B was analysed by UPLC/Q-TOF-MS/MS, and the protective effect of EEP-B on the proliferation of lipopolysaccharide (LPS)-induced MAECs was determined by Cell Counting Kit-8 (CCK-8) assays. The protein levels of inflammatory cytokines tumour necrosis factor-α (TNF-α) and interleukin- 6 (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA), and ICAM-1, VCAM-1 and MCP-1 expressions were analysed by western blotting. The results showed that a total of 24 compounds belonging to cinnamic acids and flavonoids, including 3,5-diisopentenyl-4-hydroxycinnamic acid (artepillin C), kaempferide, 3-isoprenyl p-coumaric acid, pinocembrin and 4′-methoxy pinobanksin, were identified in EEP-B. Among them, a new component, suggested to be 5-isoprenyl caffeic acid p-coumaric acid ester, was reported for the first time. The LPS-induced levels of TNF-α, IL-6, ICAM-1, VCAM-1 and MCP-1 were downregulated in response to 5, 10 and 20 μg/mL EEP-B. This study revealed that EEP-B could reduce LPS-induced inflammatory reactions, improve cell survival, and protect MAECs by regulating ICAM-1, VCAM-1 and MCP-1 expression. These findings could provide a theoretical basis for MAEC treatment using EEP-B.

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“…Between, the 17th and 20th centuries, propolis became very popular in Europe due to its antibacterial activity. During the Second World War, propolis was used as an antimicrobial and anti‐inflammatory agent …”

Section: Propolismentioning

confidence: 99%

Propolis: types, composition, biological activities, and veterinary product patent prospecting

et al. 2019

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Propolis is a resinous substance composed of a mixture of different plant parts and molecules secreted by bees. Chemically, it is defined as a complex matrix containing biologically active molecules with antibacterial, antifungal, antiviral, antiparasitic, hepatoprotective, and immunomodulatory activities. It is widely employed in cosmetic formulations and pharmaceutical products and is one of the most widely used natural products. However, the effects and strength of these biological activities depend on the chemical profile and composition of each propolis type. This composition is associated with the diversity of local flora, the place and period of collection, and the genetics of the bees. In this context, the objective of this review was to investigate the biological, chemical, and microbiological properties of propolis. A technological prospection was also performed on patents for products designed to be used in animal health. Our investigation shows that the literature contains diverse studies dedicated to comparing and describing the composition and therapeutic properties of propolis. These studies demonstrate the potential biological use of propolis in veterinary medicine, showing the applications of propolis extracts in different formulations. However, there are a low number of propolis‐based veterinary products with a registered patent. Thus, the development of products based on propolis is a promising market to be exploited. © 2019 Society of Chemical Industry

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The use of Brazilian propolis for discovery and development of novel anti-inflammatory drugs

Cited by 97 publications

References 59 publications

Effect of propolis on preserving human periodontal ligament cells and regulating pro‐inflammatory cytokines

Effect of propolis on preserving human periodontal ligament cells and regulating pro‐inflammatory cytokines

The Chemical Composition of Brazilian Green Propolis and Its Protective Effects on Mouse Aortic Endothelial Cells against Inflammatory Injury

Propolis: types, composition, biological activities, and veterinary product patent prospecting

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