The Use of Biomaterials to Treat Abdominal Hernias

Zogbi, Luciano

doi:10.5772/24313

Cited by 19 publications

(25 citation statements)

References 52 publications

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“…Some examples include: autogenous fascia lata (Bongartz 2005), autologous tunica vaginalis communis (Pratrummintra and others 2013) porcine dermal collagen (Frankland 1986), porcine small intestinal submucosa (Lee and others 2012), equine pericardium (Zerwes and others 2011) and synthetic mesh implants (Vnuk and others 2006, Szabo and others 2007, Mishina and Watanabe 2010). Surgical techniques using synthetic mesh implants result in fewer recurrences than techniques which do not use mesh (Zogbi 2011). …”

Section: Discussionmentioning

confidence: 99%

Perineal herniorrhaphy in a dog using a cone‐shaped polypropylene mesh implant

Villamil¹,

Carrera²

2016

Vet Record Case Reports

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A 10-year-old neutered male shih tzu was presented due to a history of rectal tenesmus, dyschezia and constipation for the previous two months. Physical assessment disclosed swelling on the left ischiorectal fossa, lateral to the anus. The swollen area was fluctuant, and the content was reducible. Rectal examination revealed rectal dilation and deviation. Perineal area palpation and rectal examination in addition to the history and clinical signs conduced to a diagnosis of perineal hernia. The patient was treated surgically, a herniorrhaphy being performed. A cone-shaped polypropylene mesh implant was used as herniorrhaphy technique. Clinical signs were successfully controlled with the surgical procedure. No complications or hernia recurrence have been reported to date.

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Section: Discussionmentioning

confidence: 99%

Perineal herniorrhaphy in a dog using a cone‐shaped polypropylene mesh implant

Villamil¹,

Carrera²

2016

Vet Record Case Reports

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“…; Leroy et al . ; Zogbi ). In group III rats, Masson's trichrome stain demonstrated that some of the collagen fibres were irregularly arranged and stained pale blue, while others were regularly arranged and stained dark blue.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that the reinforcement of the abdominal wall with polypropylene mesh is achieved not only by the tensile strength of the prosthetic material, but also as a result of a fibrotic reaction induced by the mesh. The mesh filaments and pores act as a foundation for the deposition of connective tissue leading to the integration of mesh material into the subcutaneous tissue (Schachtrupp et al 2003;Leroy et al 2006;Zogbi 2011). In group III rats, Masson's trichrome stain demonstrated that some of the collagen fibres were irregularly arranged and stained pale blue, while others were regularly arranged and stained dark blue.…”

Section: Discussionmentioning

confidence: 99%

Effect of alpha lipoic acid co‐administration on structural and immunohistochemical changes in subcutaneous tissue of anterior abdominal wall of adult male albino rat in response to polypropylene mesh implantation

Mazroa

Asker

et al. 2015

Int J Experimental Path

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Polypropylene mesh is commonly used in the treatment of abdominal hernia. Different approaches were addressed to improve their tissue integration and consequently reduce long-term complications. This study aimed to investigate the effect of alpha-lipoic acid (ALA) co-administration on structural and immunohistochemical (IHC) changes in the subcutaneous tissues of the anterior abdominal wall of the adult rat in response to polypropylene mesh implantation. Forty adult male albino rats were divided into: group I (control), group II (receiving ALA), group III (polypropylene mesh implantation) and group IV (mesh implantation + ALA co-administration). After 4 weeks, subcutaneous tissue samples were prepared for light microscopy and IHC study of CD34 as a marker for angiogenesis. In groups I and II rats, positive CD34 expression was demonstrated by IHC reaction, localized to endothelial cells lining small blood vessels. Group III showed an excess inflammatory reaction, deposition of both regular and irregularly arranged collagen fibres around mesh pores and few elastic fibres. CD34-positive was detected not only in cells lining small blood vessels but also in other cells scattered in the connective tissue indicating angiogenesis. In group IV, ALA co-administration resulted in less inflammatory reaction, regular collagen deposition, enhanced elastic fibres synthesis and a significant increase in CD34-positive cells and small blood vessels reflecting improved angiogenesis. ALA co-administration with polypropylene mesh implantation controlled the inflammatory reaction, helped regular collagen deposition, enhanced elastic fibres synthesis and improved angiogenesis in the subcutaneous tissue of anterior abdominal wall of adult albino rats, suggesting a possible role of ALA in optimizing mesh integration in subcutaneous tissue.

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“…Since 1985, various alterations of these three dominant materials have made up the backbone of the currently available synthetic materials. Modifications include, but are not limited to: weight, pore size, density, ability to biodegrade, and addition of composite adhesion or antimicrobial barriers (Zogbi, 2011). These modifications are highlighted in the following sections.…”

Section: History Of Hernia Biomaterialsmentioning

confidence: 99%