The use of allogeneic freeze-dried skin grafts in the oral environment

Carroll, Peter B.; Tow, Herman D.; Vernino, Arthur R.

doi:10.1016/0030-4220(74)90410-1

Cited by 20 publications

(12 citation statements)

References 11 publications

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“…Previous reports have shown that this tissue quickly regains its structural properties after reconstitution and is easily used to cover the operative site. 9,11…”

Section: Allogeneic Fdsmentioning

confidence: 99%

“…generally and in the oral cavity in particular has been reviewed in previous publications. [8][9][10] It has been re ported recently that freeze-dried skin (FDS) allografts are biologically acceptable in the oral cavities of pri mates. 9 The histologic picture at various time intervals indicated that FDS was well tolerated by the host and that inflammation and osteoclastic activity were mini mal.…”

mentioning

confidence: 94%

“…[8][9][10] It has been re ported recently that freeze-dried skin (FDS) allografts are biologically acceptable in the oral cavities of pri mates. 9 The histologic picture at various time intervals indicated that FDS was well tolerated by the host and that inflammation and osteoclastic activity were mini mal. 9 It has been suggested that FDS has certain advan tages over fresh skin as an allograft material.…”

mentioning

confidence: 96%

“…9 The histologic picture at various time intervals indicated that FDS was well tolerated by the host and that inflammation and osteoclastic activity were mini mal. 9 It has been suggested that FDS has certain advan tages over fresh skin as an allograft material. One of the greatest advantages is that allogeneic FDS is essen tially nonimmunogenic, and therefore does not appear to stimulate the graft-rejection phenomena.…”

mentioning

confidence: 99%

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Evaluation of the Use of Freeze‐dried Skin Allografts in the Treatment of Human Mucogingival Problems

Yukna

Tow

Carroll³

et al. 1977

Journal of Periodontology

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The purpose of this investigation was to evaluate the clinical responses to freeze-dried skin allografts when used to correct mucogingival problems in humans. FDS was obtained by the NMRI Tissue Bank after processing by standard procedures. The recipient sites were prepared using the standard partial thickness dissection with apical periosteal separation. Rehydrated FDS was sutured into place to completely cover the recipient sites. Routine postoperative procedures were performed. Evaluations were made by means of calibrated periodontal probe measurements, Kodachromes, and radiographs preoperatively and up to 12 months postoperatively. Fourteen patients received 24 FDS allografts over a total of 56 tooth sites. All treated teeth showed a substantial increase (greater than 2 mm) in the width of the zone of keratinized gingiva at all postoperative time periods (2.88 +/- 1.57 mm at 12 months). Other findings included a mean gain of attachment of 0.40 +/- 1.08 mm, a mean decrease in recession of 0.12 +/- 0.91 mm, and mean decrease in pocket depth of 0.33 +/- 0.53 mm. Patient comfort was good, and there were no untoward sequelae, even in patients receiving multiple grafts. This study indicates that FDS allografts are an acceptable and beneficial material for treatment of mucogingival problems in humans.

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“…Previous reports have shown that this tissue quickly regains its structural properties after reconstitution and is easily used to cover the operative site. 9,11…”

Section: Allogeneic Fdsmentioning

confidence: 99%

mentioning

confidence: 94%

mentioning

confidence: 96%

mentioning

confidence: 99%

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Evaluation of the Use of Freeze‐dried Skin Allografts in the Treatment of Human Mucogingival Problems

Yukna

Tow

Carroll³

et al. 1977

Journal of Periodontology

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“…25,29 Freeze-dried skin and FDDMA allografts are composed mainly of collagen and have been shown to be acceptable and beneficial when used intra-orally. 1,13,14,16,[42][43][44][45][46][47][48] of freeze-dried skin allograft as a biologic bandage covering surgically traumatized alveolar bone has demonstrated supracrestal cementogenesis and an increased amount of connective tissue attachment to the surgically exposed roots when compared with routine flap replacement.1 Additional advantages to the use of allogeneic freeze-dried skin or dura mater, or other freeze-dried soft tissues, are the availability of large amounts of donor tissue for multiple sites, the ease of storage in vacuum bottles at room temperature, and virtual absence of immunogenicity. [49][50][51] The objective of this study was to clinically compare the use of e-PTFE and freeze-dried dura mater allografts (FDDMA) as a biologic cover over Class II furcation osseous defects in mandibular molars.…”

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confidence: 99%

Clinical Human Comparison of Expanded Polytetrafluoroethylene Barrier Membrane and Freeze‐Dried Dura Mater Allografts for Guided Tissue Regeneration of Lost Periodontal Support. I. Mandibular Molar Class II Furcations

Yukna¹

1992

Journal of Periodontology

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The response of mandibular Class II facial furcations to guided tissue regeneration treatment with expanded polytetrafluoroethylene barrier membrane (e-PTFE) or freeze-dried dura mater allograft (FDDMA) barriers was evaluated in 11 pairs of molars in 11 patients. Following initial preparation, full thickness flaps were raised in the area being treated, the bone and furcation defects debrided of granulomatous tissue, and the involved root surfaces mechanically and chemically prepared. By random allocation, e-PTFE or FDDMA barriers were fitted over the furcations, secured in place, and the host flap repositioned or coronally positioned. Postsurgical deplaquing was performed every 10 days leading up to e-PTFE removal at about 6 weeks (the resorbable FDDMA did not require removal). Continuing supportive periodontal therapy was provided until surgical re-entry at one year for documentation and any further necessary treatment. Direct clinical measurements demonstrated essentially similar clinical results with both barrier materials for bone and soft tissue changes (few statistically or clinically significant differences). Exceptions were the amount of horizontal furcation fill and the change in the width of the keratinized gingiva, both of which were better with FDDMA (P less than 0.05). Improvements in open probing attachment levels observed at the time of e-PTFE removal were lost over the intervening months, more so for the vertical than the horizontal component of the furcation lesion. Intrapatient comparisons suggested better horizontal furcation responses with FDDMA. The findings of this study suggest equal clinical results with e-PTFE and FDDMA barriers utilizing the GTR technique. These results in Class II mandibular furcations are less favorable than those reported by others. Barrier techniques to handicap the race between different tissues of the periodontal complex appear to be of some clinical benefit and deserve further evaluation.

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Soft tissue substitutes in non-root coverage procedures: a systematic review and meta-analysis

et al. 2017

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ObjectivesThe present systematic review compared the effectiveness of soft tissue substitutes (STSs) and autogenous free gingival grafts (FGGs) in non-root-coverage procedures to increase keratinized tissue (KT) width around teeth.Materials and methodsIncluded studies fulfilled the following main eligibility criteria: (a) preclinical in vivo or human controlled trials using FGG as control, (b) non-root-coverage procedures, and (c) assessment of KT width. Meta-analysis was performed on the gain in KT width (primary outcome variable) and several secondary variables.ResultsEight human trials with short observation time evaluating five different STSs were identified. FGG yielded consistently significantly (p < 0.001) larger increase in KT width irrespective whether the comparison regarded an acellular matrix or a tissue-engineered STS. Further, FGG yielded consistently ≥2 mm KT width postoperatively, while use of STS did not, in the few studies reporting on this outcome. On the other hand, STSs resulted in significantly better aesthetic outcomes and received greater patient preference (p < 0.001).ConclusionsBased on relatively limited evidence, in non-root-coverage procedures, FGG (1) resulted consistently in significantly larger increase in KT width compared to STS and (2) yielded consistently ≥2 mm KT width postoperatively, while STSs did not. STSs yielded significantly better aesthetic outcomes, received greater patient preference, and appeared safe.Clinical relevanceLarger and more predictable increase in KT width is achieved with FGG, but STSs may be considered when aesthetics is important. Clinical studies reporting relevant posttreatment outcomes, e.g., postop KT width ≥2 mm, on the long-term (>6 months) are warranted.Electronic supplementary materialThe online version of this article (doi:10.1007/s00784-016-2044-4) contains supplementary material, which is available to authorized users.

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The use of allogeneic freeze-dried skin grafts in the oral environment

Cited by 20 publications

References 11 publications

Evaluation of the Use of Freeze‐dried Skin Allografts in the Treatment of Human Mucogingival Problems

Evaluation of the Use of Freeze‐dried Skin Allografts in the Treatment of Human Mucogingival Problems

Clinical Human Comparison of Expanded Polytetrafluoroethylene Barrier Membrane and Freeze‐Dried Dura Mater Allografts for Guided Tissue Regeneration of Lost Periodontal Support. I. Mandibular Molar Class II Furcations

Soft tissue substitutes in non-root coverage procedures: a systematic review and meta-analysis

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