The Use of a Novel Porcine Derived Acellular Dermal Matrix (Mucoderm) in Peri-Implant Soft Tissue Augmentation: Preliminary Results of a Prospective Pilot Cohort Study

Abstract

Objective Over the years, several techniques have been proposed for soft tissue augmentation around dental implants in order to improve keratinized mucosa width (KMW). Recently, a porcine derived acellular dermal matrix (Mucoderm®) has been proposed as autogenous graft substitute in order to avoid palatal harvesting and obtain comparable results to connective tissue grafts, in terms of aesthetics and function. The aim of this study is to present the one-year follow-up results of this matrix in peri-implant soft tissue augmentation procedures. Material and Methods Twelve patients were enrolled in this pilot prospective study: a dental implant was placed in the upper premolar area and, at implant uncovering after eight weeks, the matrix was inserted. KMW gain was considered as primary outcome variable. Results After one month from matrix insertion, mean KMW was 7.86±3.22 mm (100%), with no statistically significant intragroup variations (p>0.05). No membrane exposures or wound healing complications occurred during postoperative phase and, after one year, mean KMW was 5.67±2.12 mm (72.13%). Conclusions The results of the present pilot study indicate that by placing a Mucoderm membrane during implant surgery the keratinized tissue width can be augmented, and the width remains stable for the assessment period of 12 months. Further studies with greater power and longer investigation period are needed to confirm the suggestion for clinical use. Clinical trial registration number is EudraCT number 2018-000147-16.

Volumetric soft tissue alterations in the early healing phase after peri‐ implant soft tissue contour augmentation with a porcine collagen matrix versus the autologous connective tissue graft: A controlled clinical trial

“…In a recently published clinical pilot study (Papi & Pompa, 2018) were not measured. However, the results of their study showed uneventful healing in all cases (n = 12).…”

A 3-Year Prospective Study on a Porcine-Derived Acellular Collagen Matrix to Re-Establish Convexity at the Buccal Aspect of Single Implants in the Molar Area: A Volumetric Analysis

“…A newly developed porcine-derived acellular collagen matrix (PDCM) (Mucoderm ® , Botiss gmbh, Berlin, Germany) composed of non-crosslinked natural type I and type III collagen was introduced and found to be successful for gingival augmentation and root coverage [16][17][18][19][20][21][22][23]. More recently, the matrix was proposed as an autogenous graft substitute for increasing soft tissue thickness under closed healing conditions.…”

Biofunctionalization of porcine-derived collagen matrices with platelet rich fibrin: influence on angiogenesis in vitro and in vivo

“…This effect may explain the results of this study obtained in the YSM model where native collagen matrices showed lower numbers of vessels and branching points in comparison to the untreated YSM. All three CM analyzed in this study are frequently used in clinical routine for soft and hard tissue regeneration and thickening procedures around teeth and dental implants with a significant benefit on keratinized mucosa width augmentation 4 weeks after implant insertion demonstrated [48]. Furthermore, a long-lasting barrier function with slow biodegradation for the porcine pericardium membrane could be shown in vitro [4].…”

“…However, the in vivo experiments displayed better results in terms of vessel numbers and density in favor for mucoderm and collprotect matrices. A possible explanation may be seen in the fact that via the 3D architecture host cell migration and penetration could be enhanced by its interconnected structure that may lead to an increased microvessel formation and therefore angiogenesis [20,48]. However, future in vivo studies are needed to reveal a possible superiority from one bio-functionalized CM that can be recommended for clinical use.…”