The use of a new analgesic-tranquilliser mixture in dogs

Crooks, JL; Whiteley, H. J.; Jenkins, J. G.; Gf, Blane

doi:10.1136/vr.87.17.498

Cited by 4 publications

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“…Both these effects could be reversed by intravenous diprenorphine in doses of 6-35 ug/kg, i.e. about three times that of the preceding dose of etorphine; a similar ratio is used in veterinary practice for the reversal of etorphine-induced immobilization (Crooks et al, 1970). All nine animals from which post-stimulus histograms were prepared gave similar results.…”

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confidence: 70%

“…When used in veterinary practice for the immobilization of animals larger doses are used, e.g. 7-48 ,Ag/kg, i.m., for the dog (Crooks, Whiteley, Jenkins & Blane, 1970). As a major aim in this study was a possible effect of etorphine on cortical synapses, the doses used in the rat were in the range of those producing catatonia (2 to 12 ,ug/kg, i.v.).…”

Section: Resultsmentioning

confidence: 99%

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Effect of etorphine, morphine and diprenorphine on neurones of the cerebral cortex and spinal cord of the rat

Biscoe

Duggan

Lodge

1972

British J Pharmacology

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Summary1. The actions of etorphine, morphine and diprenorphine were investigated on neurones of the cerebral cortex and spinal cord of rats anaesthetized with pentobarbitone.2. In the cerebral cortex, intravenous etorphine increased the latency of the primary evoked response to a peripheral nerve stimulus and suppressed the rhythmical after-discharge. Diprenorphine reversed this effect. These actions were demonstrated on both field potentials and unit firing. 3. Morphine had no effect on the primary response but the frequency of afterdischarge bursts was reduced and there was an increase in firing between bursts. 4. In the cerebral cortex, electrophoretically applied etorphine reduced afterdischarges when applied for long periods but had no effect on the depressant actions of glycine and y-aminobutyric acid (GABA) nor on the excitant action of acetylcholine and L-glutamate. Similarly there was no alteration by etorphine of the effects of glycine, GABA and L-glutamate on spinal cord neurones. 5. It is concluded that etorphine may act pre-synaptically in the cerebral cortex.

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confidence: 70%

Section: Resultsmentioning

confidence: 99%