The use of a cartilage decellularized matrix scaffold for the repair of osteochondral defects: the importance of long-term studies in a large animal model

Bolaños, Rafael A. Vindas; Cokelaere, Stefan; McDermott, J.M. Estrada; Benders, K.E.M.; Gbureck, Uwe; Plomp, Saskia; Weinans, Harrie; Groll, Jürgen; Weeren, P.R. van; Malda, Jos

doi:10.1016/j.joca.2016.08.005

Cited by 47 publications

(54 citation statements)

References 30 publications

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“…These benefits promote the development of ECM-like matrices derived from molecular building-blocks, such as elastin-like polymers [139], peptide amphiphiles [140] or the commercially available Puramatrix (3DM) [141], that imitate the function and structure of native ECM. Empirical works in animal models of osteoarthritis have shown the beneficial impact of these constructs [142]. According to the gathered data, constructs containing matrices with cells were more valuable than matrices alone in treating defects [142].…”

Section: The Next Generation Biomaterials For Cartilage Tissue Enginementioning

confidence: 99%

“…Empirical works in animal models of osteoarthritis have shown the beneficial impact of these constructs [142]. According to the gathered data, constructs containing matrices with cells were more valuable than matrices alone in treating defects [142]. Due to these benefits, generating treatment strategies using both constituents for articular cartilage regeneration/repair is more useable.…”

Section: The Next Generation Biomaterials For Cartilage Tissue Enginementioning

confidence: 99%

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The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Eftekhari

Dizaj

Sharifi

et al. 2020

IJMS

100

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The repair and regeneration of articular cartilage represent important challenges for orthopedic investigators and surgeons worldwide due to its avascular, aneural structure, cellular arrangement, and dense extracellular structure. Although abundant efforts have been paid to provide tissue-engineered grafts, the use of therapeutically cell-based options for repairing cartilage remains unsolved in the clinic. Merging a clinical perspective with recent progress in nanotechnology can be helpful for developing efficient cartilage replacements. Nanomaterials, < 100 nm structural elements, can control different properties of materials by collecting them at nanometric sizes. The integration of nanomaterials holds promise in developing scaffolds that better simulate the extracellular matrix (ECM) environment of cartilage to enhance the interaction of scaffold with the cells and improve the functionality of the engineered-tissue construct. This technology not only can be used for the healing of focal defects but can also be used for extensive osteoarthritic degenerative alterations in the joint. In this review paper, we will emphasize the recent investigations of articular cartilage repair/regeneration via biomaterials. Also, the application of novel technologies and materials is discussed.

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Section: The Next Generation Biomaterials For Cartilage Tissue Enginementioning

confidence: 99%

Section: The Next Generation Biomaterials For Cartilage Tissue Enginementioning

confidence: 99%

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Eftekhari

Dizaj

Sharifi

et al. 2020

IJMS

100

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“…A wide range of smaller osteochondral constructs have been successfully generated using AM alone or in combination with conventional techniques, including casting, freeze‐drying and solvent casting/particle leaching . Even though the generation of a long‐term functional solution in osteochondral tissue engineering remains challenging, in vivo approaches with 3D printed osteochondral plugs have already been reported …”

Section: Mimicking the Layered Structure Of Native Tissuementioning

confidence: 99%

“…[101][102][103][104] Even though the generation of a long-term functional solution in osteochondral tissue engineering remains challenging, in vivo approaches with 3D printed osteochondral plugs have already been reported. 97,[105][106][107] There is now the opportunity to generate larger personal implants, as biofabrication can provide highly accurate anatomical structures 62,108-110 using different materials, either with 111,112 or without 113,114 the aid of a sacrificial support. Feasibility of this concept has been successfully demonstrated in rabbit models, for example, the manufacturing of total knee 72 and humeral head replacements.…”

Section: Improved Integrationmentioning

confidence: 99%

From intricate to integrated: Biofabrication of articulating joints

Groen

Diloksumpan²,

Weeren³

et al. 2017

Journal Orthopaedic Research

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Articulating joints owe their function to the specialized architecture and the complex interplay between multiple tissues including cartilage, bone and synovium. Especially the cartilage component has limited self‐healing capacity and damage often leads to the onset of osteoarthritis, eventually resulting in failure of the joint as an organ. Although in its infancy, biofabrication has emerged as a promising technology to reproduce the intricate organization of the joint, thus enabling the introduction of novel surgical treatments, regenerative therapies, and new sets of tools to enhance our understanding of joint physiology and pathology. Herein, we address the current challenges to recapitulate the complexity of articulating joints and how biofabrication could overcome them. The combination of multiple materials, biological cues and cells in a layer‐by‐layer fashion, can assist in reproducing both the zonal organization of cartilage and the gradual transition from resilient cartilage toward the subchondral bone in biofabricated osteochondral grafts. In this way, optimal integration of engineered constructs with the natural surrounding tissues can be obtained. Mechanical characteristics, including the smoothness and low friction that are hallmarks of the articular surface, can be tuned with multi‐head or hybrid printers by controlling the spatial patterning of printed structures. Moreover, biofabrication can use digital medical images as blueprints for printing patient‐specific implants. Finally, the current rapid advances in biofabrication hold significant potential for developing joint‐on‐a‐chip models for personalized medicine and drug testing or even for the creation of implants that may be used to treat larger parts of the articulating joint. © 2017 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res 35:2089–2097, 2017.

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“…A total of 105 papers [ 54 – 158 ] were included in the systematic analysis. The data indicated that micro-CT was used only qualitatively in around 15% of the papers [ 63 , 74 , 75 , 79 , 95 , 102 , 106 , 108 , 112 , 116 , 122 , 129 , 133 , 146 , 149 , 158 ], and only quantitatively in 9.5% of the papers [ 55 , 78 , 83 , 85 , 98 , 111 , 125 , 131 , 137 , 155 ]. Micro-CT was used both qualitatively and quantitatively in the rest of the papers [ 54 , 56 – 62 , 64 – 73 , 76 , 77 , 80 – 82 , 84 , 86 – 94 , 96 , 97 , 99 – 101 , 103 – 105 , 107 , 109 , 110 , 113 – 115 , 117 – 121 , 123 , 124 , 126 – 128 , 130 , 132 , 134 – 136 , 138 – 145 , 147 , 148 ,…”

Section: Introductionmentioning

confidence: 99%

Micro-CT – a digital 3D microstructural voyage into scaffolds: a systematic review of the reported methods and results

2018

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BackgroundCell behavior is the key to tissue regeneration. Given the fact that most of the cells used in tissue engineering are anchorage-dependent, their behavior including adhesion, growth, migration, matrix synthesis, and differentiation is related to the design of the scaffolds. Thus, characterization of the scaffolds is highly required. Micro-computed tomography (micro-CT) provides a powerful platform to analyze, visualize, and explore any portion of interest in the scaffold in a 3D fashion without cutting or destroying it with the benefit of almost no sample preparation need.Main bodyThis review highlights the relationship between the scaffold microstructure and cell behavior, and provides the basics of the micro-CT method. In this work, we also analyzed the original papers that were published in 2016 through a systematic search to address the need for specific improvements in the methods section of the papers including the amount of provided information from the obtained results.ConclusionMicro-CT offers a unique microstructural analysis of biomaterials, notwithstanding the associated challenges and limitations. Future studies that will include micro-CT characterization of scaffolds should report the important details of the method, and the derived quantitative and qualitative information can be maximized.

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The use of a cartilage decellularized matrix scaffold for the repair of osteochondral defects: the importance of long-term studies in a large animal model

Abstract: The implants failed to produce reasonable repair tissue in this osteochondral defect model, although the CaP base in the -P group integrated well with the recipient bone. The study stresses the importance of long-term in vivo studies to assess the efficacy of cartilage repair techniques.

Cited by 47 publications

References 30 publications

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

From intricate to integrated: Biofabrication of articulating joints

Micro-CT – a digital 3D microstructural voyage into scaffolds: a systematic review of the reported methods and results

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