The use of 3,3-bis(2-imidazolyl) propionic acid (bip-OH) as a new chelating ligand for Re(CO)3 and Ru complexes: Formation of organometallic PNA oligomers with (bip)Re(CO)3 and their interaction with complementary DNA

Hamzavi, Ramin; Happ, T.; Weitershaus, Katharina; Metzler‐Nolte, Nils

doi:10.1016/j.jorganchem.2004.09.009

Cited by 35 publications

(19 citation statements)

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“…No PNA oligomers with covalently bound electrochemically active metal complexes were known at the time. Our group has subsequently reported the first organometallic PNA monomers and oligomers, [17][18][19]10] followed by other groups. [20,21] No attempt has been made so far to exploit the favourable combination of properties in metallocene-PNA conjugates for electrochemical DNA detection.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Electrochemical Characterization of Metallocene–PNA Oligomers

2005

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Section: Introductionmentioning

confidence: 99%

Synthesis and Electrochemical Characterization of Metallocene–PNA Oligomers

2005

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“…Ferrocene, 28,29 cobaltocenium 6, 29 rhenium and technetium tricarbonyls, 30,31 and ruthenocene 32 have all been tagged to PNA using amide bond forming reactions. Click chemistry has also been used, both to introduce ferrocene to the center of the strand 33 and to synthesize a family of ferrocene-conjugated PNA probes, 34 with the thermal stability of duplexes formed with DNA then investigated.…”

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confidence: 99%

Metal–Carbon Bonds in Biopolymer Conjugates: Bioorganometallic Nucleic Acid Chemistry

Duprey

Tucker

2013

Chemistry Letters

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“…The use of fluorescent organometallic complexes to label biological substrates is beginning to provide some exciting alternatives to the more traditional organic dyes [126], with suitable iridium [127][128][129], rhodium [130], platinum [131], rhenium [132][133][134][135] and osmium [136] examples having recently been reported. The Re diimine 'wires' (13g and 13h, Fig.…”

Section: Detection Of Proteinsmentioning

confidence: 99%

Chromo- and Fluorogenic Organometallic Sensors

Fletcher

Lagunas

2009

Topics in Organometallic Chemistry

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Compounds that change their absorption and/or emission properties in the presence of a target ion or molecule have been studied for many years as the basis for optical sensing. Within this group of compounds, a variety of organometallic complexes have been proposed for the detection of a wide range of analytes such as cations (including H + ), anions, gases (e.g. O 2 , SO 2 , organic vapours), small organic molecules, and large biomolecules (e.g. proteins, DNA). This chapter focuses on work reported within the last few years in the area of organometallic sensors. Some of the most extensively studied systems incorporate metal moieties with intense long-lived metal-to-ligand charge transfer (MLCT) excited states as the reporter or indicator unit, such as fac-tricarbonyl Re(I) complexes, cyclometallated Ir(III) species, and diimine Ru(II) or Os(II) derivatives. Other commonly used organometallic sensors are based on Pt-alkynyls and ferrocene fragments. To these reporters, an appropriate recognition or analyte-binding unit is usually attached so that a detectable modification on the colour and/or the emission of the complex occurs upon binding of the analyte. Examples of recognition sites include macrocycles for the binding of cations, H-bonding units selective to specific anions, and DNA intercalating fragments. A different approach is used for the detection of some gases or vapours, where the sensor's response is associated with changes in the crystal packing of the complex on absorption of the gas, or to direct coordination of the analyte to the metal centre.

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The use of 3,3-bis(2-imidazolyl) propionic acid (bip-OH) as a new chelating ligand for Re(CO)3 and Ru complexes: Formation of organometallic PNA oligomers with (bip)Re(CO)3 and their interaction with complementary DNA

Cited by 35 publications

References 40 publications

Synthesis and Electrochemical Characterization of Metallocene–PNA Oligomers

Synthesis and Electrochemical Characterization of Metallocene–PNA Oligomers

Metal–Carbon Bonds in Biopolymer Conjugates: Bioorganometallic Nucleic Acid Chemistry

Chromo- and Fluorogenic Organometallic Sensors

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