The use of 18F for Bone Scanning

Abstract

A comparative study of the use of 85Sr chloride and 18F as fluoride for bone scanning is reported. Measurements carried out indicate that, in general, their degree of uptake into tumours is equally good. Since 18F delivers a radiation dose to bone of only 1/200 that from 85Sr, greatly increased activities can be given. The optimum time for scanning with 18F is about one hour following intravenous injection, when only 6 per cent of the administered dose has been found to remain in the blood, and a further 6 per cent has been excreted in the urine. 85Sr is not removed from the blood so rapidly, and 18 per cent has been found to be present after a similar time interval. Experience of 57 18F bone scans and over 100 85 Sr bone scans is reported and the 18F scans are compared with the corresponding radiographs. The major disadvantage of using 18F is its accumulation in the bladder, but 85Sr has the corresponding disadvantage of localising in the faeces in the bowel. It has been shown that 18F can be given orally, though incomplete absorption from the stomach reduces the counting rate over bone and makes bone scanning impossible in the stomach area. It is concluded that the advantages of 18F far outweigh its disadvantages for bone scanning.

Radioisotope scanning of brain, liver, lung and bone with a note on tumour localizing agents

“…Thus Charkes, Sklaroff & Young (1966) found 21% of abnormal scans, in patients suffering from back pain and a cancer elsewhere, who had negative X-rays. Similar figures for positive scans with negative radiology have been noted by De Nardo (1966), French & McCready (1967) and Galasko et al (1968). In a follow up of such cases the lesion will become apparent radiologically up to 18 months later.…”

“…18Fluorine is a cyclotron produced radioisotope with a half-life of 2 hr. Due to the method of production and its short half-life this isotope is not generally available, but the quality of scans produced by 18fluorine is better than that when strontium is used (French & McCready, 1967;Galasko et al, 1968; Ronai, Winchell & Anger, 1968). In the last year or so a number of other agents have been suggested and assessed on an experimental basis.…”

The Kinetics and Reproducibility of 18F-Sodium Fluoride for Oncology Using Current PET Camera Technology

“…If scanning is performed during a period of rapid bone uptake, it will have a higher temporal dependence than if it is performed during slow or stable uptake. The uptake plateau has been previously studied, using less sensitive and lower-resolution scanners, with inconsistent results, ranging from 1 to 5 h after injection (1,2), and thus, there is a need to reconsider dose, uptake kinetics, and reproducibility in light of modern technology.…”

Imaging of a rat osteoarthritis model using 18F-fluoride positron emission tomography

“…It is rapidly taken up by the skeleton (peak uptake on the order of 1 h after injection), and once bound in the bone compartment, there is negligible outflux. 18 F-fluoride is rapidly cleared from the blood (90-95% clearance by 1 h), resulting in low background for bone imaging [14][15][16]. In addition, 18 F has a short halflife (approximately 110 min), which makes it ideal for serial, non-invasive imaging.…”