Imaging of a rat osteoarthritis model using 18F-fluoride positron emission tomography

Umemoto, Yusuke; Oka, T.; Inoue, Tomio; Saito, T.

doi:10.1007/s12149-010-0411-9

Cited by 21 publications

(10 citation statements)

References 24 publications

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“…FDG is a positron-emitting radiopharmaceutical that accumulates at sites of increased glucose metabolism [15]. Incidental uptake of FDG is frequently detected in the joints of patients undergoing PET evaluation and has been attributed to degenerative or inflammatory changes related to arthritis [16–18]. However, few studies have compared the symptomatic and radiologic findings of OA with FDG uptake on PET imaging, particularly using a well-accepted questionnaire of OA diagnosis.…”

Section: Introductionmentioning

confidence: 99%

The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis

Nguyen

Burt

Baldassarre

et al. 2018

Nuclear Medicine Communications

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Section: Introductionmentioning

confidence: 99%

The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis

Nguyen

Burt

Baldassarre

et al. 2018

Nuclear Medicine Communications

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“…Recently, 18 F-FDG based PET was utilized in a rat model to investigate the early stages of OA. This study indicated its significant potential to detect OA within 2 weeks of induction, while, in histology, a minimum of 8 weeks was required [ 284 ]. Even though PET was not extensively used for OA evaluation previously, it is rapidly finding niches in investigating OA in conjunction with other techniques such as CT and MRI.…”

Section: Measures Of Disease Outcomementioning

confidence: 99%

Animal models of osteoarthritis: classification, update, and measurement of outcomes

et al. 2016

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Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world today. It is a debilitating chronic illness causing pain and immense discomfort to the affected individual. Significant research is currently ongoing to understand its pathophysiology and develop successful treatment regimens based on this knowledge. Animal models have played a key role in achieving this goal. Animal models currently used to study osteoarthritis can be classified based on the etiology under investigation, primary osteoarthritis, and post-traumatic osteoarthritis, to better clarify the relationship between these models and the pathogenesis of the disease. Non-invasive animal models have shown significant promise in understanding early osteoarthritic changes. Imaging modalities play a pivotal role in understanding the pathogenesis of OA and the correlation with pain. These imaging studies would also allow in vivo surveillance of the disease as a function of time in the animal model. This review summarizes the current understanding of the disease pathogenesis, invasive and non-invasive animal models, imaging modalities, and pain assessment techniques in the animals.

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“…It has great potential for molecular musculoskeletal imaging, including OA and osteoporosis. 8-18,20-25 …”

Section: Introductionmentioning

confidence: 99%

Feasibility of Na¹⁸F PET/CT and MRI for Noninvasive In Vivo Quantification of Knee Pathophysiological Bone Metabolism in a Canine Model of Post-traumatic Osteoarthritis

et al. 2017

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Purpose:To assess and quantify by molecular imaging knee osseous metabolic changes serially in an in vivo canine model of posttraumatic osteoarthritis (PTOA) of the knee utilizing sodium fluoride (Na18F) positron emission tomography (PET)/computed tomography (CT) coregistered with magnetic resonance imaging (MRI).Materials and Methods:Sodium fluoride PET imaging of 5 canines was performed prior to anterior cruciate ligament transection (ACLT) and 2 times post-ACLT (3 and 12 weeks). The PET/CT was coregistered with MRI, enabling serial anatomically guided visual and quantitative three-dimensional (3D) region of interest (ROI) assessment by maximum standardized uptake value.Results:Prior to ACLT, every 3D ROI assessed in both knees showed no Na18F uptake above background. The uptake of Na18F in the bone of the ACLT knees increased exponentially, presenting significantly higher uptake at 12 weeks in every region compared to the ACLT knees at baseline. Furthermore, the uninjured contralateral limb and the ipsilateral distal bones and joints presented Na18F uptake at 3 and 12 weeks post-ACLT.Conclusion:This study demonstrated that Na18F PET/CT coregistered with MRI is a feasible molecular imaging biomarker to assess knee osseous metabolic changes serially in an in vivo canine model of knee PTOA. Moreover, it brings a novel musculoskeletal preclinical imaging methodology that can provide unique insights into PTOA pathophysiology.

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Imaging of a rat osteoarthritis model using 18F-fluoride positron emission tomography

Abstract: Our results suggest that (18)F-fluoride is potentially useful for the early detection of osteoarthritic changes.

Cited by 21 publications

References 24 publications

The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis

The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis

Animal models of osteoarthritis: classification, update, and measurement of outcomes

Feasibility of Na¹⁸F PET/CT and MRI for Noninvasive In Vivo Quantification of Knee Pathophysiological Bone Metabolism in a Canine Model of Post-traumatic Osteoarthritis

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Imaging of a rat osteoarthritis model using 18F-fluoride positron emission tomography

Abstract: Our results suggest that (18)F-fluoride is potentially useful for the early detection of osteoarthritic changes.

Cited by 21 publications

References 24 publications

The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis

The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis

Animal models of osteoarthritis: classification, update, and measurement of outcomes

Feasibility of Na18F PET/CT and MRI for Noninvasive In Vivo Quantification of Knee Pathophysiological Bone Metabolism in a Canine Model of Post-traumatic Osteoarthritis

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Feasibility of Na¹⁸F PET/CT and MRI for Noninvasive In Vivo Quantification of Knee Pathophysiological Bone Metabolism in a Canine Model of Post-traumatic Osteoarthritis