The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis

Nguyen, Brian J.; Burt, Ashley; Baldassarre, Randall L.; Smitaman, Edward; Morshedi, Maud M.; Kao, Steven D.; Chang, Eric Y.; Obrzut, Sebastian

doi:10.1097/mnm.0000000000000858

Cited by 16 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While not well-studied in the facet joints, there is evidence that FDG activity can indicate an early response to systemic treatment in other inflammatory conditions, including inflammatory arthritis. 17,18 We found that high-grade perifacet findings were more common with gadolinium, supporting the assertion that further investigation with MR imaging protocols including gadolinium, rather than fat-suppressed T2 images alone, would be reasonable. The results also provide initial assessment of the approximate frequency and concordance of potential imaging biomarkers on multiplane fat-suppressed T2, fat-suppressed T1 gadolinium-enhanced, and FDG-PET images using a standardized protocol.…”

Section: Discussionsupporting

confidence: 63%

Comparison of [¹⁸F] FDG-PET/MRI and Clinical Findings for Assessment of Suspected Lumbar Facet Joint Pain: A Prospective Study to Characterize Candidate Nonanatomic Imaging Biomarkers and Potential Impact on Management

Lehman¹,

Diehn²,

Broski³

et al. 2019

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE: Prior retrospective studies have suggested that both T2 hyperintensity and gadolinium enhancement on fat-suppressed MR imaging are associated with lumbar facet joint pain, but prospective evaluation of FDG-PET/MR imaging with a standardized protocol and correlation to clinical findings are lacking. The primary aim was to prospectively assess a standardized FDG-PET/MRI protocol in patients with suspected facetogenic low back pain, with determination of the concordance of imaging and clinical findings. MATERIALS AND METHODS: Ten patients with clinically suspected facetogenic low back pain were prospectively recruited with a designation of specific facet joints implicated clinically. Subsequently, patients underwent an FDG-PET/MR imaging examination with gadolinium. Each facet joint was graded for perifacet signal change on MR imaging and FDG activity. The frequency and correlation of MR imaging, FDG-PET, and clinical findings were determined. RESULTS: FDG activity showed high concordance with high overall MR imaging scores (concordance correlation coefficient = 0.79). There was concordance of the clinical side of pain with the side of high overall MR imaging scores and increased FDG activity on 12/20 (60%) sides. Both a high overall MR imaging score (concordance correlation coefficient = 0.12) and FDG-PET findings positive for increased activity (concordance correlation coefficient = 0.10) had low concordance with the specific clinically implicated facet joints. Increased FDG activity or high MR imaging scores or both were present in only 10/29 (34%) facet joints that had been clinically selected for percutaneous intervention. Eleven (11%) facet joints that had not been selected for treatment demonstrated these imaging findings. CONCLUSIONS: There was low concordance of perifacet signal change and FDG activity with clinically implicated facet joints. This could indicate either the potential to change patient management or a lack of biomarker accuracy. Therefore, additional larger randomized studies with the use of comparative medial branch blocks would be useful to further investigate the clinical utility of these findings.

show abstract

Section: Discussionsupporting

confidence: 63%

Comparison of [¹⁸F] FDG-PET/MRI and Clinical Findings for Assessment of Suspected Lumbar Facet Joint Pain: A Prospective Study to Characterize Candidate Nonanatomic Imaging Biomarkers and Potential Impact on Management

Lehman¹,

Diehn²,

Broski³

et al. 2019

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…First, although the patient population potentially was relatively small, this study describes a unique cohort of acromegaly patients in remission, and is the first study describing both clinical and radiographic OA in the shoulder and feet. Modified KL atlases based on the existing KL atlases of the knee and hand were used for the glenohumeral and MTP joints, similar to previous studies [49][50][51][52][53][54][55]. No (modified) KL atlas was available for the acromioclavicular and sternoclavicular joints, and, therefore, as mentioned prior, solely the glenohumeral joint of the shoulder was assessed.…”

Section: Discussionmentioning

confidence: 99%

“…Since, to date, no official KL atlas for the shoulder and forefoot joints exists, glenohumeral joints, and MTP1-5 and IP1 joints were semi-quantitively scored according to a modified KL scoring system based on the KL atlas of the knee and hands (especially MCP joints), respectively, similar to several previous studies [49][50][51][52][53][54][55]. KL scores were defined as follows: 0, normal bone contour, no JSN, no OP, no sclerosis; 1, doubtful JSN, possible OP; 2, definite OP and possible JSN; 3, multiple moderate OP, definite JSN, some sclerosis, and possible bone contour deformity; 4, severe OP, marked JSN, severe sclerosis, and definite bone contour deformity.…”

Section: Assessment Of Radiographic Oamentioning

confidence: 99%

See 1 more Smart Citation

Clinical and radiographic assessment of peripheral joints in controlled acromegaly

et al. 2022

View full text Add to dashboard Cite

Purpose Acromegalic arthropathy is a well-known phenomenon, occurring in most patients regardless of disease status. To date, solely hips, knees, hands, and spinal joints have been radiographically assessed. Therefore, this study aimed to assess the prevalence of joint symptoms and radiographic osteoarthritis (OA) of new, and established peripheral joint sites in well-controlled acromegaly. Methods Fifty-one acromegaly patients (56% female, mean age 64 ± 12 years) in long-term remission for 18.3 years (median, IQR 7.2–25.4) were included. Nineteen patients currently received pharmacological treatment. Self-reported joint complaints were assessed using standardized interviews. Self-reported disability of the upper and lower limbs, and health-related quality of life (HR-QoL) were evaluated using validated questionnaires. Radiographic OA [defined as Kellgren & Lawrence (KL) ≥ 2] was scored using (modified) KL methods. Results Radiographic signs of OA were present in 46 patients (90.2%) with ≥ 2 joints affected in virtually all of these patients (N = 44; 95.7%). Radiographic MTP1 OA was as prevalent as radiographic knee OA (N = 26, 51.0%), and radiographic glenohumeral OA was similarly prevalent as hip OA [N = 21 (41.2%) vs. N = 24 (47.1%)]. Risk factors for radiographic glenohumeral OA were higher pre-treatment IGF-1 levels [OR 1.06 (1.01–1.12), P = 0.021], and current pharmacological treatment [OR 5.01 (1.03–24.54), P = 0.047], whereas no risk factors for MTP1 joint OA could be identified. Conclusion Similar to previously-assessed peripheral joints, clinical and radiographic arthropathy of the shoulder and feet were prevalent in controlled acromegaly. Further studies on adequate management strategies of acromegalic arthropathy are needed.

show abstract

“…Imaging is part of the diagnostic workup of patients with suspected fungal infection [ 9 ]. Imaging is able to stage the infection, to detect occult or disseminated infection, to monitor antifungal therapy, and to provide prognostic information [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response

Ankrah

Sathekge

Dierckx

et al. 2021

JoF

View full text Add to dashboard Cite

The human response to invading fungi includes a series of events that detect, kill, or clear the fungi. If the metabolic host response is unable to eliminate the fungi, an infection ensues. Some of the host response’s metabolic events to fungi can be imaged with molecules labelled with radionuclides. Several important clinical applications have been found with radiolabelled biomolecules of inflammation. 18F-fluorodeoxyglucose is the tracer that has been most widely investigated in the host defence of fungi. This tracer has added value in the early detection of infection, in staging and visualising dissemination of infection, and in monitoring antifungal treatment. Radiolabelled antimicrobial peptides showed promising results, but large prospective studies in fungal infection are lacking. Other tracers have also been used in imaging events of the host response, such as the migration of white blood cells at sites of infection, nutritional immunity in iron metabolism, and radiolabelled monoclonal antibodies. Many tracers are still at the preclinical stage. Some tracers require further studies before translation into clinical use. The application of therapeutic radionuclides offers a very promising clinical application of these tracers in managing drug-resistant fungi.

show abstract

The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis

Cited by 16 publications

References 25 publications

Comparison of [¹⁸F] FDG-PET/MRI and Clinical Findings for Assessment of Suspected Lumbar Facet Joint Pain: A Prospective Study to Characterize Candidate Nonanatomic Imaging Biomarkers and Potential Impact on Management

Comparison of [¹⁸F] FDG-PET/MRI and Clinical Findings for Assessment of Suspected Lumbar Facet Joint Pain: A Prospective Study to Characterize Candidate Nonanatomic Imaging Biomarkers and Potential Impact on Management

Clinical and radiographic assessment of peripheral joints in controlled acromegaly

Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response

Contact Info

Product

Resources

About

The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis

Cited by 16 publications

References 25 publications

Comparison of [18F] FDG-PET/MRI and Clinical Findings for Assessment of Suspected Lumbar Facet Joint Pain: A Prospective Study to Characterize Candidate Nonanatomic Imaging Biomarkers and Potential Impact on Management

Comparison of [18F] FDG-PET/MRI and Clinical Findings for Assessment of Suspected Lumbar Facet Joint Pain: A Prospective Study to Characterize Candidate Nonanatomic Imaging Biomarkers and Potential Impact on Management

Clinical and radiographic assessment of peripheral joints in controlled acromegaly

Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response

Contact Info

Product

Resources

About

Comparison of [¹⁸F] FDG-PET/MRI and Clinical Findings for Assessment of Suspected Lumbar Facet Joint Pain: A Prospective Study to Characterize Candidate Nonanatomic Imaging Biomarkers and Potential Impact on Management

Comparison of [¹⁸F] FDG-PET/MRI and Clinical Findings for Assessment of Suspected Lumbar Facet Joint Pain: A Prospective Study to Characterize Candidate Nonanatomic Imaging Biomarkers and Potential Impact on Management