The Underlying Function and Structural Organization of the Intracellular Protein Corona on Graphdiyne Oxide Nanosheet for Local Immunomodulation

Guo, Mengyu; Zhao, Lina; Liu, Jing; Wang, Xiaofeng; Yao, Haodong; Chang, Xueling; Liu, Ying; Liu, Jiaming; You, Min; Ren, Jiayu; Wang, Fuhui; Wang, Liming; Wang, Yaling; Liu, Huibiao; Li, Yuliang; Zhao, Yuliang; Cai, Rong; Chen, Chunying

doi:10.1021/acs.nanolett.1c01048

Cited by 64 publications

(50 citation statements)

References 33 publications

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“…Lastly, it has been shown that 2D carbon-based NPs− graphdiyne oxide (GDYO) nanosheets can thermodynamically interact with an IPC composed of a signal transducer and activator of transcription 3 (STAT3), triggering the immunomodulation of macrophages by changing their phenotype. Indeed, the authors indicated that the recommended synthesized nanoplatforms could be used for local immunomodulation based on the structural assembly of the intracellular PC in macrophages [179].…”

Section: Organization Of the Intracellular Pcmentioning

confidence: 99%

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Khan

Sharifi

Gleghorn

et al. 2022

Journal of Controlled Release

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Section: Organization Of the Intracellular Pcmentioning

confidence: 99%

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Khan

Sharifi

Gleghorn

et al. 2022

Journal of Controlled Release

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“…Tumor evasion can be divided into three phases, namely, elimination, equilibrium, and escape phases. A variety of immune cells participate in the elimination phase; however, some immune cells are transformed by immunosuppressive factors and contribute to tumor metastasis and recurrence (Gao et al, 2019; Guo et al, 2021; Ovais et al, 2019). The mechanisms involved in the escape of cancer cells from the immune system have been widely studied, and are known to include changes in the expression patterns/levels of immune checkpoint proteins such as PD‐1 and CTLA‐4, dysregulated cytokine expression, and neoantigen generation (Bhatia & Kumar, 2014; Kennedy & Salama, 2020).…”

Section: Mof‐based Nucleic Acid Therapy In Combination With Other Tre...mentioning

confidence: 99%

Combinational application of metal–organic frameworks‐based nanozyme and nucleic acid delivery in cancer therapy

Lin

Zhang

et al. 2022

WIREs Nanomed Nanobiotechnol

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The rapid development of nanotechnology has generated numerous ideas for cancer treatment, and a wide variety of relevant nanoparticle platforms have been reported. Metal–organic frameworks (MOFs) have been widely investigated as an anti‐cancer drug delivery vehicle owing to their unique porous hybrid structure, biocompatibility, structural tunability, and multi‐functionality. MOF materials with catalytic activity, known as nanozymes, have applications in photodynamic and chemodynamic therapy. Nucleic acids have also attracted increasing research attention owing to their programmability, ease of synthesis, and versatility. A variety of functional DNAs and RNAs have been applied both therapeutically (gene‐targeting drugs for cancer treatment) and nontherapeutically (used as modified materials to enhance the therapeutic effects of other nanomedicines). The combined use of MOFs and functional nucleic acids have been extensively investigated and has been associated with excellent tumor‐suppressor activity in various treatment methods. In this review, we summarize the progress in the research and development of tumor therapy based on MOFs and nucleic acid delivery over recent years, focusing on the combinational use of different delivery and design strategies for MOF/therapeutic nucleic acid platforms. We further summarize the strategies for combining MOFs (universal carrier, functional carrier) and nucleic acids (therapeutic nucleic acids, nontherapeutic nucleic acids) and discuss the corresponding therapeutic effects in cancer treatment. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies

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“…As a result, cellular uptake of GDYO nanosheets attenuated the expression levels of M2 macrophage‐related cytokines, perturbing M2 activation (Figure 10b). [ 147 ] The adsorption of specific coronal protein on NPs can also change the identity of NPs and influence their interaction with biological systems. Cao et al.…”

Section: Nps For Protein or Dna Recognitionmentioning

confidence: 99%

“…a,b) Adapted with permission. [ 147 ] Copyright 2021, American Chemical Society. c) Schematic representation of preferential adsorption of NDs to TβRII and their effects on TGFβ signaling blockade.…”

Section: Nps For Protein or Dna Recognitionmentioning

confidence: 99%

Protein‐Mimicking Nanoparticles in Biosystems

Fan

2022

Advanced Materials

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Up to now, most protein-mimicking NPs can be classified into one of the four categories: 1) enzyme-like catalytic activities have been identified among a wide variety of nanomaterials including noble-metal-, metal-oxide-, carbon-, and metal-organic framework (MOF)-based nanozymes. Similar to engineered enzymes, the catalytic properties of nanozymes can be finetuned by the change of composition and surface modification. In addition, dual-or multiple-enzyme mimetic activities can be integrated into one type of NPs. [3,4] 2) Fluorescent NPs such as quantum dots (QDs), upconversion NPs (UCNPs), aggregation-induced emission (AIE) NPs, and semiconducting polymer NPs (SPNPs)/polymer dots (Pdots), can serve as attractive alternatives or even better replacement of fluorescent proteins, bringing broader benefits for bioimaging and light-activated therapy. NPs of this category possess high fluorescence intensity, tunable fluorescence wavelengths, and high photostability. These unique optical properties make them ideal fluorophores for long-term tracking and simultaneous monitoring of multiple biological species. [5] Moreover, some types of fluorescent NPs can be tuned to emit in the near-infrared (NIR) window, providing great advantages for deep-tissue imaging. [6] 3) More and more studies reveal that certain types of NPs show high affinity binding to specific proteins or DNA sequences. Such interaction leads to the utilization of NPs for protein or DNA recognition, and may actively alter cellular signaling and communication when introduced into living systems. [7,8] Alternatively, the DNA binding capacity can be used for the docking of DNA strands for the assembly of supramolecular structures. [9] 4) The bottom-up construction of NPs has created a diversity of nanostructures with close similarities in both morphology and function to natural protein scaffolds. NPs based on DNA strands, polymers, or carbon nanotubes (CNTs) can form membrane-embedded hollow structures (nanopores) analogous to biological ion channels. Extracellular or intracellular scaffold-mimicking NPs have been designed to mediate cell-cell contact, communication, and signaling cascade. [10,11] Besides, curved nanostructures can mimic membrane sculpting proteins to mediate membrane extrusion or invagination. [12,13] Compared with natural proteins, the abovementioned categories of protein-mimicking NPs are cost-efficient, physically, and chemically stable, and can be constructed with more versatility for translating into a broad range of applications.Proteins are essential elements for almost all life activities. The emergence of nanotechnology offers innovative strategies to create a diversity of nanoparticles (NPs) with intrinsic capacities of mimicking the functions of proteins. These artificial mimics are produced in a cost-efficient and controllable manner, with their protein-mimicking performances comparable or superior to those of natural proteins. Moreover, they can be endowed with additional functionalities that are absent in natural proteins, such ...

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The Underlying Function and Structural Organization of the Intracellular Protein Corona on Graphdiyne Oxide Nanosheet for Local Immunomodulation

Cited by 64 publications

References 33 publications

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Combinational application of metal–organic frameworks‐based nanozyme and nucleic acid delivery in cancer therapy

Protein‐Mimicking Nanoparticles in Biosystems

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