The UNC-Wisconsin Rhesus Macaque Neurodevelopment Database: A Structural MRI and DTI Database of Early Postnatal Development

Young, Jeffrey T.; Shi, Yundi; Niethammer, Marc; Grauer, Michael; Coe, Christopher L.; Lubach, Gabriele R.; Davis, Brian F.; Budin, François; Knickmeyer, Rebecca; Alexander, Andrew L.; Styner, Martin

doi:10.3389/fnins.2017.00029

Cited by 46 publications

(56 citation statements)

References 66 publications

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“…This study was performed based on a public rhesus macaque neurodevelopment dataset with 32 macaques ( Macaca mulatta , 18 males; https://www.nitrc.org/projects/uncuw_macdevmri) (Young et al, ). These macaques were reared and housed at the Harlow Primate Laboratory (HPL) at the University of Wisconsin‐Madison.…”

Section: Methodsmentioning

confidence: 99%

“…The older juveniles were housed in small social groups or as a pair to provide companionship after weaning, instead of being reared by their mothers during breast‐fed stage, in order to facilitate their normal socialization and ensure standardized rearing conditions. More information on subjects can be found in Young et al ().…”

Section: Methodsmentioning

confidence: 99%

“…Macaques were scanned by using a GE MR750 3.0 T scanner (General Electric Medical, Milwaukee, WI) with the human 8‐channel brain array coil at the Waisman Laboratory for Brain Imaging and Behavior at the University of Wisconsin‐Madison (Young et al, ). T1‐weighted images were acquired using an axial inversion recovery (IR) prepared fast gradient echo (fGRE) sequence (GE BRAVO), with parameters: TI/TR/TE = 450/8.684/3.652 ms, FOV = 140 × 140 mm, flip angle = 12°, acquisition matrix = 256 × 256, and voxel size = 0.55 × 0.55 × 0.8 mm 3 .…”

Section: Methodsmentioning

confidence: 99%

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Mapping hemispheric asymmetries of the macaque cerebral cortex during early brain development

Xia

Wang

et al. 2019

Human Brain Mapping

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Studying cortical hemispheric asymmetries during the dynamic early postnatal stages in macaque monkeys (with close phylogenetic relationship to humans) would increase our limited understanding on the possible origins, developmental trajectories, and evolutional mechanisms of brain asymmetries in nonhuman primates, but remains a blind spot to the community. Via cortical surface‐based morphometry, we comprehensively analyze hemispheric structural asymmetries in 134 longitudinal MRI scans from birth to 20 months of age from 32 healthy macaque monkeys. We reveal that most clusters of hemispheric asymmetries of cortical properties, such as surface area, cortical thickness, sulcal depth, and vertex positions, expand in the first 4 months of life, and evolve only moderately thereafter. Prominent hemispheric asymmetries are found at the inferior frontal gyrus, precentral gyrus, posterior temporal cortex, superior temporal gyrus (STG), superior temporal sulcus (STS), and cingulate cortex. Specifically, the left planum temporale and left STG consistently have larger area and thicker cortices than those on the right hemisphere, while the right STS, right cingulate cortex, and right anterior insula are consistently deeper than the left ones, partially consistent with the findings in human infants and adults. Our results thus provide a valuable reference in studying early brain development and evolution.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Mapping hemispheric asymmetries of the macaque cerebral cortex during early brain development

Xia

Wang

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…This study was performed based on a public rhesus macaque neurodevelopment data set with 32 ( Macaca mulatta ) [1], in which each monkey has 4 to 5 longitudinal MRI scans during early postnatal stages, by using a GE MR 750 3.0T scanner. The number of subjects at each age is shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Nonhuman primates, particularly the rhesus macaques ( Macaca mulatta ), are a widely used animal model for investigating the neural substrates of human social behaviors and complex cognitive functions, due to their phylogenetic closeness to humans [1, 2]. The gene-editing technologies further make it feasible to create monkey models for human neurodevelopmental disorders (e.g., autism spectral disorder and Rett syndrome [3]).…”

Section: Introductionmentioning

confidence: 99%

Construction of spatiotemporal infant cortical surface atlas of rhesus macaque

Wang

Xia

et al. 2018

2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018)

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As a widely used animal model in MR imaging studies, rhesus macaque helps to better understand both normal and abnormal neural development in the human brain. However, the available adult macaque brain atlases are not well suitable for study of brain development at the early postnatal stage, since this stage undergoes dramatic changes in brain appearances and structures. Building age matched atlases for this critical period is thus highly desirable yet still lacking. In this paper, we construct the first spatiotemporal (4D) cortical surface atlases for rhesus macaques from 2 weeks to 24 months, using 138 longitudinal MRI scans from 32 healthy rhesus monkeys. Specifically, we first perform intra-subject cortical surface registration to obtain within-subject mean cortical surfaces. Then, we perform inter-subject registration of within-subject mean surfaces to obtain unbiased and longitudinally-consistent 4D cortical surface atlases. Based on our 4D rhesus monkey atlases, we further chart the first developmental-trajectories-based parcellation maps using the local surface area and spectral clustering algorithm. Our 4D macaque surface atlases and parcellation maps will greatly facilitate early brain development studies of macaques.

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Effects of anesthesia exposure on postnatal maturation of white matter in rhesus monkeys

Tomlinson

Vlasova

Al‐Ali

et al. 2023

Developmental Psychobiology

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There is increasing concern about the potential effects of anesthesia exposure on the developing brain. The effects of relatively brief anesthesia exposures used repeatedly to acquire serial magnetic resonance imaging scans could be examined prospectively in rhesus macaques. We analyzed magnetic resonance diffusion tensor imaging (DTI) of 32 rhesus macaques (14 females, 18 males) aged 2 weeks to 36 months to assess postnatal white matter (WM) maturation. We investigated the longitudinal relationships between each DTI property and anesthesia exposure, taking age, sex, and weight of the monkeys into consideration. Quantification of anesthesia exposure was normalized to account for variation in exposures. Segmented linear regression with two knots provided the best model for quantifying WM DTI properties across brain development as well as the summative effect of anesthesia exposure. The resulting model revealed statistically significant age and anesthesia effects in most WM tracts. Our analysis indicated there were major effects on WM associated with low levels of anesthesia even when repeated as few as three times. Fractional anisotropy values were reduced across several WM tracts in the brain, indicating that anesthesia exposure may delay WM maturation, and highlight the potential clinical concerns with even a few exposures in young children.

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The UNC-Wisconsin Rhesus Macaque Neurodevelopment Database: A Structural MRI and DTI Database of Early Postnatal Development

Cited by 46 publications

References 66 publications

Mapping hemispheric asymmetries of the macaque cerebral cortex during early brain development

Mapping hemispheric asymmetries of the macaque cerebral cortex during early brain development

Construction of spatiotemporal infant cortical surface atlas of rhesus macaque

Effects of anesthesia exposure on postnatal maturation of white matter in rhesus monkeys

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