The ultrastructure of the myometrium of the rat with special reference to the innervation

Silva, Douglas G.

doi:10.1002/ar.1091580104

Cited by 31 publications

(12 citation statements)

References 13 publications

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“…Decreased gastrointestinal motility and constipation are well known consequences of treatment with atropine (lIenderson & Roepke, 1937;Ambache, 1955) and ganglion blocking agents (Paton & Zaimis, 1951). Cholinesterase inhibition, on the other hand, increases gut motility due to the accumulation of acetylcholine (Holmstedt, 1959) (Adham & Schenk, 1969;Silva, 1966). This would go along with the low level of acetylcholinesterase activity which was found in the uterus in the present study.…”

Section: Discussionsupporting

confidence: 52%

Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor

Foley

McPhillips

1973

British J Pharmacology

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Summary Daily i.p. administration, for eight days, of the cholinesterase inhibitor disulfoton to rats produced mild to moderate signs of intoxication (tremors, incontinence and diarrhoea) but no deaths. Segments of ileum taken from the treated rats were subsensitive to carbachol but the vas deferens and the uterus did not exhibit any change in sensitivity to carbachol. The sensitivity to acetylcholine was increased in the ileum and vas deferens but not in the uterus. Acetylcholinesterase activity was 60–70% inhibited in all three tissues.

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Section: Discussionsupporting

confidence: 52%

Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor

Foley

McPhillips

1973

British J Pharmacology

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“…1974) that innervate the myometrial smooth muscle as well as the uterine vascular bed [Silva. 1967: Marshall.…”

Section: Introductionmentioning

confidence: 99%

Changes in Cholinergic and Noradrenergic Nerves in the Pregnant and Postpartum Uterus of the Albino Rat and Guinea Pig

Moustafa

1988

Cells Tissues Organs

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The present study was undertaken to investigate the structural changes in both cholinesterase(ChE)-positive nerve fibers and adrenergic nerves with formaldehyde-induced fluorescence in pregnant and postpartum uteri of both the albino rat and guinea pig. Particular attention was directed to the relationship between these changes and the local factors associated with the growing fetus. ChE reaction was absent in the control and pregnant uterus of the guinea pig. In the albino rat, there were signs of degeneration in pregnancy. These were evidenced by vacuolation of large nerve trunks and the presence of focal segments with very faint reaction along the course of the nerve bundles. Myometrial segments from fetus-containing horns showed some fragmented nerve fibers, but at the same time some other normal ones. Most of the fine nerve bundles gave a weak reaction. Three weeks after delivery, multiple ChE fibers were found in the uterus of the albino rat. The normal appearance was, however, not regained and some nerve fibers were still fragmented. Noradrenergic (NA) nerve fibers were disintegrated and markedly reduced in number in the myometrium of the pregnant uterus of both the guinea pig and albino rat, particularly in the uterine horns that were distended by fetuses. The number of NA fibers was not significantly reduced in the tubal ends of the albino rat uterus. Three weeks after delivery, normal NA fibers were seen in the myometrium of both the albino rat and guinea pig uterus. Nerves with reduced fluorescence reaction were observed less frequently.

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“…The niariimalian uterus receives a well-debeloped supply of adrenergic nerves (Owman, Sjoherg and Sjostrand 1974) which innervate the myornetrial smooth muscle cells as well as the uterine vascular bed (Silva 1967, Marshall 1970, Hervonen and Kanerva 1973, Sporrong et id. 1977.…”

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confidence: 99%

Regional changes in structural and functional integrity of myometrial adrenergic nerves in pregnant guinea‐pig, and their relationship to the localization of the conceptus

Thorbert

Alm

Owman

et al. 1978

Acta Physiologica Scandinavica

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Pregnancy is accompanied by a reduction in uterine noradrenaline, and the study was undertaken to investigate associated structural and functional integrity of the sympathetic nerves in the organ. The formaldehyde-induced fluorescence of adrenergic nerves was studied in different uterine regions before and after in vitro incubation or injection with alpha-methyl-noradrenaline in pregnant and puerperal guinea-pig uterus at 6 time periods, from early pregnancy (about 20 days post coitum) to 3 months post partum. The changes were related to the position of the fetuses, which were often present in only one of the two uterine horns. There was a drastic loss of fluorescent adrenergic nerves in myometrial tissue from horns distended by fetuses. Attempts to restore this fluorescence by incubation or injection with alpha-methyl-noradrenaline were essentially ineffective. Tissues from uterine regions outside (and not distended by) fetuses (in the case of early pregnancy), from horns devoid of fetuses (in the case of unilateral pregnancy), and from the cervix also lost their noradrenaline-fluorescent nerves, but this occurred at a much later stage of pregnancy. After treatment with alpha-methyl-noradrenaline, a fluorescent plexus of sympathetic nerves could be restored to a considerable extent in these latter tissues. In puerperal animals the horn that had been devoid of fetuses regained its endogenous fluorescence much faster, and the uptake of alpha-methyl-noradrenaline was more efficient, than in the horn which had contained fetuses. In this latter horn clear signs of restoration of endogenous adrenergic fluorescence and a clear uptake capacity was not found until 3 months after delivery. In the tubal end of the uterus, the reduction in the number of fluorescent nerves was only insignificant, and the region thus clearly differed from the rest of the uterus. It is concluded that (1) there are clear regional differences with regard to the disappearance of the noradrenaline transmitter in the uterus, (2) this disappearance in early pregnancy is related to the position of the conceptus, and (3) the changes involve de- and regenerative phenomena as well as alterations in transmitter levels of intact neurons.

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The ultrastructure of the myometrium of the rat with special reference to the innervation

Cited by 31 publications

References 13 publications

Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor

Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor

Changes in Cholinergic and Noradrenergic Nerves in the Pregnant and Postpartum Uterus of the Albino Rat and Guinea Pig

Regional changes in structural and functional integrity of myometrial adrenergic nerves in pregnant guinea‐pig, and their relationship to the localization of the conceptus

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