The ultrastructure of primary hepatocellular cancer in man

Schaff, Z.; Lapis, K.; Sáfrány, L

doi:10.1007/bf00542717

Cited by 32 publications

(3 citation statements)

References 21 publications

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“…Although the peroxisomes in human HCC have been extensively studied by EM [6,9,10,26,28,29,32,36], this is the first report combining the specificity of the immunolabeling with the advantages of sampling large sections by light microscopy for the investigation of their alterations. Thus, the abundance and the distribution of peroxisomes are clearly visualized in HCC (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…The results of routine electron microscopical (EM) studies, however, have been somewhat controversial. While some authors found only a few microbodies in hepatic tumors [6,36], others reported numerous profiles of peroxisomes and peroxisome-like structures in hepatocellular carcinomas (HCCs) [26,29,32]. The identification of peroxisomes in routine EM preparations, particularly in the absence of crystalline cores of urate oxidase -as observed in the human liver -however, can be difficult, and the results of such studies without proper sampling and morphometry can be highly biased.…”

Section: Introductionmentioning

confidence: 99%

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Immunocytochemical investigation of catalase and peroxisomal lipid β-oxidation enzymes in human hepatocellular tumors and liver cirrhosis

Litwin

Beier²,

Völkl³

et al. 1999

Virchows Archiv

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A significant reduction of catalase activity, a peroxisomal marker enzyme, occurs in human hepatic neoplasias, but no information is available on other peroxisomal proteins. We have studied by means of immunohistochemistry four specific proteins of peroxisomes (catalase and three enzymes of lipid beta-oxidation) in human hepatocellular tumors of various differentiation grades from adenoma to anaplastic carcinoma. In all tumors, except the adenomas, the tumor cells contained fewer peroxisomes than extrafocal hepatocytes and the reduction of antigenic sites in the tumor types generally correlated with the degree of tumor dedifferentiation as assessed by classical histopathological criteria. Two poorly differentiated tumors had no detectable peroxisomes at all. There were no major differences in the intensities of the immunocytochemical staining for all four studied peroxisomal antigens in different tumors, suggesting that the neoplastic transformation affects the biogenesis of the entire organelle and not merely the individual peroxisomal enzyme proteins. Some tumors exhibited a distinct peripheral distribution of peroxisomes. In cases with associated liver cirrhosis, the hepatocytes in the adjacent liver showed marked peroxisome proliferation, forming large perinuclear aggregates, occupying occasionally the entire cytoplasm. Taken together, our observations indicate that peroxisomes are significantly altered in both hepatocellular tumors and liver cirrhosis and, thus, could be responsible for some of the metabolic derangements observed in those disease processes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunocytochemical investigation of catalase and peroxisomal lipid β-oxidation enzymes in human hepatocellular tumors and liver cirrhosis

Litwin

Beier²,

Völkl³

et al. 1999

Virchows Archiv

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“…Unsere elektronenmikroskopischen Befunde lassen erkennen, daß die wesentlichen Merkmale der Geschwulst mit den Angaben in der Literatur bezüglich der hepatozellulären Karzinome übereinstimmen (4,14,20,21,29,43,44,51). Der Mangel der Zellverbindungsstrukturen, die ungenügende Entwicklung der Sinusoide und die geringe Zahl der Kupfferschen Zellen deuten auf den niedrigen Differenzierungsgrad der untersuchten Geschwulst hin.…”

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Primäres Leberkarzinom nach mehrjähriger Anwendung eines oralen Kontrazeptivums und Schwangerschaft

Balázs¹,

Gergely²,

Winkler³

1977

Dtsch med Wochenschr

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A 32-year-old woman who had taken oral contraceptives for seven years, became pregnant after omitting the drug and had a normal child. Soon after a malignant hepatic tumour became apparent of which she died after three months. The tumour was a hepatocellular carcinoma, of low differentiation under the electron microscope. The tumour cells contained fibrils similar to alcoholic hyaline. A review of published reports suggests the possibility that the oral contraceptives and the hormonal influence of the pregnancy together played an important role in the development of the malignant tumour.

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Ultrastructure of fibrolamellar oncocytic hepatoma

Farhi

Shikes

Silverberg

1982

Cancer

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The fibrolamellar variant of hepatocellular carcinoma is described and the ultrastructural findings in three cases are reported. The findings confirm the oncoytic nature of the tumor and the presence of distinctive bands of collagen. This tumor may represent a neoplasm of hepatic oncocytes. It appears to have distinct epidemiologic differences from other hepatocellular carcinomas, which typically arise in cirrhotic livers, and it may have a better prognosis. As such, it should be recognized as a distinct clinicopathologic subset in the broad group of hepatocellular carcinomas.

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The ultrastructure of primary hepatocellular cancer in man

Cited by 32 publications

References 21 publications

Immunocytochemical investigation of catalase and peroxisomal lipid β-oxidation enzymes in human hepatocellular tumors and liver cirrhosis

Immunocytochemical investigation of catalase and peroxisomal lipid β-oxidation enzymes in human hepatocellular tumors and liver cirrhosis

Primäres Leberkarzinom nach mehrjähriger Anwendung eines oralen Kontrazeptivums und Schwangerschaft

Ultrastructure of fibrolamellar oncocytic hepatoma

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