The Ultrastructure and Resorptive Pattern of Cancellous Onlay Bone Grafts in the Craniofacial Skeleton

Juvenile Swine Surgical Alveolar Cleft Model to Test Novel Autologous Stem Cell Therapies

“…[4][5][6][7] Delayed repair of the alveolar cleft using cancellous bone from the iliac crest has eliminated growth restriction, but it still requires a secondary surgical site. 7 Tissue-engineered strategies offer a promising alternative to the current treatment strategy, but require proof of equivalence to the current gold standard treatment (or evidence of improved efficacy), and safety, both in vitro, and in large animal models, before translation to humans.…”

“…Cancellous bone from the iliac crest (a marrow-based treatment, in contradistinction to rib, which is a cortical bone-based treatment) has now become the gold standard for treatment of the alveolar cleft. 7 This delay in treatment allows further growth of the craniofacial skeleton, and minimizes growth restriction 8 ; the marrowbased treatment allows more favorable and uniform healing of the graft implant site. Disadvantages of this treatment include the need for a second surgical site, donor site morbidities, 9 unpredictable resorption rates, 10 and the need to delay treatment because of insufficient cancellous bone within the iliac crest in younger patients.…”

Volume changes of autogenous bone grafts after alveolar ridge augmentation of atrophic maxillae and mandibles

“…The hypothesis is that, in addition to embryologic origin and micro-architecture composition 4,8 , bone graft remodeling depends, in ways that are different in the maxilla and in the mandible, on some of the 3D features of the bone graft (thickness, external surface, shape) and the recipient site (volume), and on the relationship between the two (a contact surface and a volume ratio). Bone remodeling probably depends on the anatomical region of the recipient site and on the graft sources.…”

Quantitative assessment of early healing of intramembranous and endochondral autogenous bone grafts using micro-computed tomography and Q-win image analyzer

“…Furthermore, BUCHMAN & OZAKI demonstrated that the micro-architecture of a graft was the basis for volume maintenance 4 . However, the majority of these studies have been performed in the context of onlay grafts.…”