The Tyler Asbestos Workers Program. I. A Medical Surveillance Model and Method

Hurst, George A.; Spivey, Charles G.; Matlage, W.T.; Miller, John M.; Faulk, Grady; Hieger, Leroy R.; McLarty, Jerry; Greenberg, S. Donald

doi:10.1080/00039896.1979.10667445

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…15 There were also 165 workers from a temporary agency who received intermittent exposure unloading the amosite from the railway wagons. 15 These workers were identified by a regional poll of temporary agencies after the NIOSH visit and as part of the TAWP. Dates of employment were available from the temporary agency.…”

Section: Methodsmentioning

confidence: 99%

“…14 The Patterson plant was the predecessor to the plant in the present study, and used some of the same equipment and raw materials. 15 The Tyler asbestos plant manufactured asbestos pipe insulation from 1954 to February of 1972, when it closed after citations from the Occupational Safety and Health Administration (OSHA) about exposure levels in excess of the regulatory standard. 16 The amosite asbestos was obtained from the Transvaal region of South Africa.…”

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confidence: 99%

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Tyler asbestos workers: mortality experience in a cohort exposed to amosite.

Levin¹,

McLarty²,

Hurst³

et al. 1998

Occup Environ Med

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Objectives-To examine the causes of death among 1130 former workers of a plant in Tyler, Texas dedicated to the manufacture of asbestos pipe insulation materials. This cohort is important and unusual because it used amosite as the only asbestiform mineral in the production process. High level exposure of such a specific type was documented through industrial hygiene surveys in the plant. Methods-Deathswere ascertained through various sources including data tapes from the Texas Department of Health and the national death index files. As many death certificates as possible were secured (304/315) and cause of death assigned. After select exclusions, 222 death certificates were used in the analysis. Causes of death were compared with age, race, and sex specific mortalities for the United States population with a commercial software package (OCMAP Version 2.0). Results-There was an excess of deaths from respiratory cancer including the bronchus, trachea, and lung (standardised mortality ratio (SMR) 277 with 95% confidence interval (95% CI) 193 to 385). Four pleural mesotheliomas and two peritoneal mesotheliomas were identified. The analysis also showed an increasing risk of respiratory malignancy with increased duration of exposure including a significant excess of total deaths from respiratory cancer with less than six months of work at the plant (SMR 268 with 95% CI 172 to 399). Conclusions-The importance of the cohort lies with the pure amosite exposure which took place in the plant and the extended period of latency which has followed. The death certificate analysis indicates the pathogenicity of amosite, the predominant commercial amphibole used in the United States. These data confirm a link between amosite asbestos and respiratory malignancy as well as mesothelioma. (Occup Environ Med 1998;55:155-160)

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Tyler asbestos workers: mortality experience in a cohort exposed to amosite.

Levin¹,

McLarty²,

Hurst³

et al. 1998

Occup Environ Med

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“…The Tyler, TX cohort was unique in several respects; namely, the workers of the pipe insulation material manufacturing plant were exposed to high levels of pure amosite for an extended period of time resulting in excess death from lung cancer (11,14). Although not prospectively designed, the availability of sequential plasma samples in this cohort, especially in some lung cancer patients, allowed meaningful molecular studies to search for diagnostic and potential early detection markers.…”

Section: Discussionmentioning

confidence: 99%

“…Former workers (n=1095) of an asbestos manufacturing plant, which operated in Tyler, TX from 1954 to 1972, were exposed to high levels of amosite dust. These workers were enrolled in a follow-up study in 1978 that included periodic collection of sputum and plasma samples (14). The lung cancer mortality in this cohort has been described (11).…”

Section: Methodsmentioning

confidence: 99%

Plasma proteomic profiling: Search for lung cancer diagnostic and early detection markers

Ali

Xiao²,

Malone³

et al. 2006

Oncol Rep

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Abstract. Environmental and occupational exposure to asbestos is among the established risk factors for lung cancer, the leading cause of cancer-related deaths in the United States. This link between exposure to asbestos and the excessive death rate from lung cancer was evident in a study of former workers of an asbestos pipe insulation manufacturing plant in Tyler, TX. We performed comparative proteomic profiling of plasma samples that were collected from nine patients within 12 months before death and their age-, raceand exposure-matched disease-free controls on strong anion exchange chips using surface-enhanced laser desorption ionization time-of-flight mass spectrometry. A distancedependent K-nearest neighbor (KNN) classification algorithm identified spectral features of m/z values 7558.9 and 15103.0 that were able to distinguish lung cancer patients from disease-free individuals with high sensitivity and specificity. The high correlation between the intensities of these two peaks (r=0.987) strongly suggests that they are the doubly and singly charged ions of the same protein product. Examination of these proteomic markers in the plasma samples of subjects from >5 years before death from lung cancer suggested that they are related to the early development of lung cancer. Validation of these biomarkers would have significant implications for the early detection of lung cancer and better management of high-risk patients.

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“…They were workers at an asbestos factory in Texas, summarized in table 1 (9), and crocidolite miners in Wittenoom, Australia (62). The 4 trials have the use of beta-carotene as a preventive agent in common, but the administered dose varied from 30 to 50 mglday.…”

Section: Health Surveillancementioning

confidence: 99%