“…In recent years, proteomics has emerged as a powerful technology to identify differential protein expressions associated with cancer development and progression. Its two most popular and reliable techniques, two‐dimensional gel electrophoresis and mass spectrometry, have been widely used in studies of different types of cancers, such as leukemia (7–9), breast cancer (10, 11), colorectal cancer (12–14), lung cancer (15–18), liver cancer (19, 20), renal cancer (21, 22), bladder cancer (23, 24), esophageal cancer (25, 26), gastric cancer (27), and cervical cancer (28). Although this technology has also been applied for the study of OSCC with clinical tissue samples (29–32) and cell lines (33–35), similar study has not been performed with our in vitro cellular carcinogenesis model of OSCC.…”