The TyG index may predict the development of cardiovascular events

Sánchez-Íñigo, Laura; Navarro‐González, David; Fernandez‐Montero, Alejandro; Pastrana-Delgado, Juan; Martínéz, J. Alfredo

doi:10.1111/eci.12583

Cited by 328 publications

(275 citation statements)

References 38 publications

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“…Notably, the cut-off point of 8.5 was quite different from the finding of 4.58 by Simental-Mendia [7], the reason for this may be explained by the different metabolic status among subjects from the two studies or the different ethnicities. The TyG level in our study was similar to that of other population from Korea [27, 32], America [33], France [30], and Spain [26], whereas the level of TyG in studies from Mexico was close to that of participants from Italy [31]. We also found that the diagnostic accuracy of TyG was superior to ALT, even if the optimal cut-off point of ALT was 20.5 U/L with a sensitivity of 66.1% and specificity of 65.9%.…”

Section: Discussionsupporting

confidence: 88%

“…Recently, there is growing interest in the TyG index. Several studies have reported that the TyG index was associated with the development of diabetes and cardiovascular diseases [26, 27]. Although the TyG index mathematical model was developed in Mexican population, our prior study showed that the TyG index was effective to identify the risk of insulin resistance (assessed by homeostasis model assessment of insulin resistance) in Chinese individuals [28].…”

Section: Discussionmentioning

confidence: 99%

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The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease

et al. 2017

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BackgroundThe triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. We aimed to investigate the ability of TyG, through comparing with the predictive value of alanine aminotransferase (ALT), to identify individuals at risk for nonalcoholic fatty liver disease (NAFLD).MethodsA cross-sectional study was conducted in a Chinese health examination cohort of 10 761 people aged above 20 years. NAFLD was diagnosed by ultrasonography.ResultsCompared with the participants in the lowest quartile of TyG, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were 1.8 (1.5–2.1), 3.0 (2.5–3.5), and 6.3 (5.3–7.5) for those in the second, the third, and the fourth quartile of TyG, whereas the corresponding ORs (95% CI) for NAFLD were 1.5 (1.3–1.7), 1.9 (1.6–2.2), and 3.1 (2.6–3.7) for the upper three quartiles of ALT. These results suggested that TyG was superior to ALT in association with NAFLD risk. According to the ROC analysis, the optimal cut-off point of TyG for NAFLD was 8.5 and the area under the ROC curve (AUC) was 0.782 (95% CI 0.773–0.790), with 72.2 and 70.5% sensitivity and specificity, respectively. The AUC of TyG was larger than that of ALT (0.715 (95% CI 0.705–0.725), P for difference <0.0001), whereas the largest AUC was obtained when adding TyG to ALT (0.804 (95% CI 0.795–0.812), P for difference <0.0001).ConclusionsTyG is effective to identify individuals at risk for NAFLD. A TyG threshold of 8.5 was highly sensitive for detecting NAFLD subjects and may be suitable as a diagnostic criterion for NAFLD in Chinese adults.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0409-6) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease

et al. 2017

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“…As we all know, IR is closely related to MetS. In addition, a recent study 27 showed that the TyG index could be a credible indicator for predicting the risk of a cardiovascular event. Therefore, we further investigated this diagnostic power of TyG for MetS.…”

Section: Discussionmentioning

confidence: 97%

Clinical surrogate markers for predicting metabolic syndrome in middle‐aged and elderly Chinese

Cui

et al. 2017

J of Diabetes Invest

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Aims/IntroductionThe present study evaluated the ability of lipid accumulation product (LAP), visceral adiposity index (VAI), and the product of triglycerides and glucose (TyG), three novel markers, in identifying metabolic syndrome (MetS) with different criteria in middle‐aged and elderly Chinese.Materials and MethodsDuring June 2012 to January 2013, 992 consecutive patients (age ≥40 years) were enrolled at Daping Hospital. The criteria of MetS were based on the International Diabetes Federation and the modified National Cholesterol Education Program's Adult Treatment Panel III. VAI, LAP and TyG were computed based on a published mathematical model.ResultsThe prevalence of MetS was 42.8%. The receiver operating characteristic curve found LAP, VAI and TyG were positively related to MetS in both criteria. The optimal cut‐offs of VAI, LAP and TyG for the modified National Cholesterol Education Program's Adult Treatment Panel III and International Diabetes Federation criteria were 2.015, 31.465 and 8.706, and 2.035, 37.99 and 8.697, respectively. After adjustment of potential confounding factors, VAI, LAP and TyG were significantly correlated with MetS in all criteria according to optimal cut‐offs. For MetS, reliable predictive value was observed in different subgroups (age and sex). LAP showed the greatest area under the curve in MetS with the International Diabetes Federation definition (area under the curve 0.887, 95% confidence interval 0.852–0.922).Conclusions AP, VAI and TyG were reliable surrogate markers for identifying MetS in middle‐aged and elderly Chinese. LAP could be a better parameter than VAI and TyG for predicting MetS in the present study.

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“…compared the TyG index with the euglycemic‐hyperinsulinemic clamp test, and suggested that TyG could be useful for the identification of individuals with decreased insulin sensitivity in 2010 . A series of cohort and cross‐sectional studies confirmed a strong correlation between the TyG index and IR, type 2 diabetes mellitus, MetS, hypertension, cardiovascular events and fatty liver both in China and elsewhere. Published studies have shown that the TyG index is helpful for the prediction and early identification of individuals at high risk of cardiometabolic diseases.…”

Section: Discussionmentioning

confidence: 99%

Fasting triglycerides and glucose index is more suitable for the identification of metabolically unhealthy individuals in the Chinese adult population: A nationwide study

Wang

Zhang

et al. 2018

J of Diabetes Invest

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Aims/Introduction Metabolic unhealth can be defined by the components of metabolic syndrome, which is closely connected to insulin resistance. We aimed to determine a simple index to identify metabolic unhealth in the Chinese adult population. Materials and Methods A total of 30,291 individuals were screened from the China National Diabetes and Metabolic Disorders Study carried out from June 2007 to May 2008. Metabolic unhealth was defined using components of metabolic syndrome, except waist circumference. We compared the three surrogate indices of insulin resistance : the product of fasting triglycerides and glucose (TyG), triglycerides divided by high‐density lipoprotein cholesterol and the metabolic score for insulin resistance for the evaluation of metabolic status. Results All indices had high sensitivity and specificity for the identification of metabolic unhealth, especially the TyG index with an area under the curve of 0.863 for men and 0.867 for women. Participants were divided into subgroups for further analysis. The TyG index also showed high diagnostic values, especially for younger individuals and men with normal waist circumference . Sex‐specific cut‐offs for three indices were also used to define metabolic unhealth. The TyG index showed the highest agreement with κ values of 0.603 and 0.605 for men and women between the components of metabolic syndrome and three indices. Conclusions We propose that the TyG index, just read in one blood laboratory test report, is simpler and more suitable for the identification of metabolically unhealthy individuals as well as who have high risk of cardiometabolic diseases of the Chinese adult population.

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The TyG index may predict the development of cardiovascular events

Abstract: The TyG index, a simple measure reflecting insulin resistance, might be useful to early identify individuals at a high risk of developing a cardiovascular event.

Cited by 328 publications

References 38 publications

The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease

The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease

Clinical surrogate markers for predicting metabolic syndrome in middle‐aged and elderly Chinese

Fasting triglycerides and glucose index is more suitable for the identification of metabolically unhealthy individuals in the Chinese adult population: A nationwide study

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