Clinical surrogate markers for predicting metabolic syndrome in middle‐aged and elderly Chinese

Abstract

Aims/IntroductionThe present study evaluated the ability of lipid accumulation product (LAP), visceral adiposity index (VAI), and the product of triglycerides and glucose (TyG), three novel markers, in identifying metabolic syndrome (MetS) with different criteria in middle‐aged and elderly Chinese.Materials and MethodsDuring June 2012 to January 2013, 992 consecutive patients (age ≥40 years) were enrolled at Daping Hospital. The criteria of MetS were based on the International Diabetes Federation and the modified National Cholesterol Education Program's Adult Treatment Panel III. VAI, LAP and TyG were computed based on a published mathematical model.ResultsThe prevalence of MetS was 42.8%. The receiver operating characteristic curve found LAP, VAI and TyG were positively related to MetS in both criteria. The optimal cut‐offs of VAI, LAP and TyG for the modified National Cholesterol Education Program's Adult Treatment Panel III and International Diabetes Federation criteria were 2.015, 31.465 and 8.706, and 2.035, 37.99 and 8.697, respectively. After adjustment of potential confounding factors, VAI, LAP and TyG were significantly correlated with MetS in all criteria according to optimal cut‐offs. For MetS, reliable predictive value was observed in different subgroups (age and sex). LAP showed the greatest area under the curve in MetS with the International Diabetes Federation definition (area under the curve 0.887, 95% confidence interval 0.852–0.922).Conclusions AP, VAI and TyG were reliable surrogate markers for identifying MetS in middle‐aged and elderly Chinese. LAP could be a better parameter than VAI and TyG for predicting MetS in the present study.

Fasting triglycerides and glucose index is more suitable for the identification of metabolically unhealthy individuals in the Chinese adult population: A nationwide study

“…compared the TyG index with the euglycemic‐hyperinsulinemic clamp test, and suggested that TyG could be useful for the identification of individuals with decreased insulin sensitivity in 2010 . A series of cohort and cross‐sectional studies confirmed a strong correlation between the TyG index and IR, type 2 diabetes mellitus, MetS, hypertension, cardiovascular events and fatty liver both in China and elsewhere. Published studies have shown that the TyG index is helpful for the prediction and early identification of individuals at high risk of cardiometabolic diseases.…”

The triglyceride-glucose index is associated with the severity of hepatic steatosis and the presence of liver fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults

“…Evidence suggests that the TyG index is tied to metabolic diseases and CVD [10,11]. The TyG index has been considered a reliable biomarker for predicting type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS) [12,13]. Several studies have even reported that the TyG index is a better predictor for coronary artery atherosclerosis and arterial stiffness when compared with HOMA-IR [14,15].…”

Obesity, metabolic syndrome and bariatric surgery: A narrative review

“…Serum gamma-glutamyl transferase was positively associated with MetS and its components in Korean children and adolescents, and could be a useful measure for identifying young people with MetS 3 . Another study found that lipid accumulation product, visceral adiposity index, and the products of triglycerides and glucose were reliable novel surrogate markers for identifying MetS in middle-aged and elderly Chinese individuals 4 . Elevated circulating member B levels of the family with sequence similarity 3 might be a predictor of MetS onset and progression 5 .…”