The triglyceride-glucose index is associated with the severity of hepatic steatosis and the presence of liver fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults

Guo, Wen; Lü, Jing; Qin, Pei; Li, Xiaona; Zhu, Wen; Wu, Juan; Xu, Nianzhen; Zhang, Qun

doi:10.1186/s12944-020-01393-6

Cited by 59 publications

(59 citation statements)

References 32 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As expected, several anthropometric or metabolic indices such as skeletal muscle mass [16], atherogenic index [17,18], Body Mass Index (BMI) [19], the ratio of Triglyceride (TG) to High-Density Lipoprotein cholesterol [20], visceral adipose tissue [21], Total cholesterol (TC) to High-Density Lipoprotein cholesterol ratio [22] and Triglyceride Glucose (TyG) [23,24], as well as blood pressure [25] had been reported to be associated with FL in both cross-sectional and cohort studies. However, most existing studies mainly focused on only one or two indices, which might have limitations for predicting FL considering the high complexity of the pathogenesis of FL.…”

Section: Introductionsupporting

confidence: 63%

WHtR may be a Better and Stronger Indictor for Fatty Liver: A Population-Based Cross-sectional Comparison Study of Anthropometric and Metabolic Indices for Identification Fatty Liver in China

Xie¹,

Pei²,

Zhou³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: This study aimed to comprehensively evaluate the predictive performance anthropometric and metabolic indices in identifying fatty liver (FL) diseases in Chinese adults. Indices including Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Total Cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein (LDL), Fasting Blood Glucose (FBG), Alanine aminotransferase (ALT and AST), Waist Circumference (WC), Waist–hip Ratio (WHR), Waist-to-Height Ratio (WHtR), Body Mass Index (BMI), Abdominal Volume Index (AVI), Atherogenic Index of Plasma (AIP), Triglyceride Glucose (TyG), and ALT/AST were selected. Methods: A total of 1748 participants aged over 18 years were included in this study. Univariate analyses were performed to determine the associations between these indices and FL with odds ratio (ORs). The predictive performance of these indices to identify FL was compared using receiver operating characteristic (ROC) curves and areas under curves (AUCs). Results: WHtR had the greatest AUC in males (AUC = 0.81) and females (AUC = 0.85). Furthermore, WC and AVI had the greatest AUC in 20-40 years (AUC = 0.96), while TyG had the greatest AUC in 40- years (AUC = 0.80) of females. And WHtR had the second diagnostic ability in both two decades of age (20-40 and 40- years) of females. Conclusions: WHtR might be the best for predicting FL in males and females, while WC and AVI might be best for identifying FL for males aged 20-40 years, while TyG for those aged over 40 years.

show abstract

Section: Introductionsupporting

confidence: 63%

WHtR may be a Better and Stronger Indictor for Fatty Liver: A Population-Based Cross-sectional Comparison Study of Anthropometric and Metabolic Indices for Identification Fatty Liver in China

Xie¹,

Pei²,

Zhou³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Bellan et al [ 51 ] suggested that, independent of the etiology of chronic liver disease, liver fibrosis is a stronger determinant of prolonged QTc interval than fatty liver. In addition, TyG index was positively related to the presence of liver fibrosis and the severity of hepatic steatosis in NAFLD [ 52 ]. Hence, it is reasonable to suggest that TyG index may be associated with hypertension, obesity, WBC count, and liver function, thereby contributing to QTc interval prolongation.…”

Section: Discussionmentioning

confidence: 99%

Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers

Lee

Hsuan

et al. 2021

IJERPH

View full text Add to dashboard Cite

Objectives: Increased triglyceride glucose (TyG) index appears to be linked to carotid and coronary atherosclerosis and calcifications and possesses an elevated future risk of developing cardiovascular disease. Corrected QT (QTc) interval prolongation is associated with ventricular arrhythmias and sudden cardiac death, and a high prevalence of prolonged QTc interval was previously reported in blue-collar workers. The purpose of this study was to find the possible causal inter-relationship between TyG index and QTc interval in a large population of Chinese male steelworkers. Methods: A total of 3189 male workers from two steel plants were enrolled. They responded to a cross-sectional questionnaire on basic attributes and lifestyle, including sleep patterns. All workers in the two plants underwent periodic health checkups, including twelve-lead electrocardiography. Structural equation modeling (SEM) was used to assess the direct and indirect effects of TyG index on QTc interval. Results: With increasing TyG index tertile, the male steelworkers had an increased QTc interval. Applying multivariate analysis, TyG index was associated independently with the odds of QTc prolongation (adjusted odds ratio = 2.73, 95% confidence interval = 1.39–5.24, p = 0.004). SEM revealed that TyG index, hypertension, obesity, lifestyle, white blood cell (WBC) count, and liver function had statistically significant direct effects on QTc interval. Furthermore, TyG index also had an indirect effect on QTc interval through hypertension, obesity, WBC count, and liver function. Moreover, lifestyle had an indirect effect on QTc interval through TyG index. The final model explained 14% of the variability in QTc interval. Conclusions: An increased TyG index was associated with QTc interval prolongation in this study, and SEM delineated possible causal pathways and inter-relationships of the risk factors contributing to the occurrence of QTc prolongation among Chinese male steelworkers.

show abstract

“…Although most studies explored the relationship between the TyG index and NAFLD risk, these studies focused on the general population [15,18,19]. Our present study focused on the associations of the TyG index, glycemic parameters, and lipid parameters with NAFLD in a T2DM population.…”

Section: Discussionmentioning

confidence: 99%

“…Lipotoxicity and glucotoxicity, which begin in hepatocyte exposure to high lipid and glucose levels, respectively, play vital roles in the development and subsequent progression of NAFLD [14]. Thus, the TyG index has been recommended as a simple and reliable indicator to identify individuals at risk for NAFLD [15].…”

Section: Introductionmentioning

confidence: 99%

Association between triglyceride–glucose index and nonalcoholic fatty liver disease in type 2 diabetes mellitus

Li¹,

Wang²,

He³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background Lipid and glucose metabolism abnormalities are associated with nonalcoholic fatty liver disease (NAFLD). The triglyceride–glucose (TyG) index is a recently developed indicator that can identify individuals at risk for NAFLD. However, the applicability of the TyG index for identifying NAFLD in patients with type 2 diabetes mellitus (T2DM) is unclear. The aim of this study was to investigate the ability of the TyG index to identify individuals at risk for NAFLD in the T2DM population. Methods A total of 2280 participants with T2DM were recruited in this cross-sectional study. The TyG index was calculated, and NAFLD was diagnosed by ultrasonography. Binary logistic regression models were used to evaluate the association of the TyG index, glycemic parameters and lipid parameters with NAFLD. Results Logistic regression analysis showed that the TyG index was significantly associated with NAFLD in subjects with T2DM, the odds ratio (OR) were 3.27 (95% confidence interval [CI], 2.03–5.27; P < 0.001) for NAFLD in the highest TyG quartile after adjustment for known confounders (Model 4). According to receiver operating characteristic (ROC) curve analysis, the optimal cut-off point of the TyG index for the risk of NAFLD was 9.3 with an area under the ROC curve of 0.683 (95% CI 0.658–0.707), a sensitivity of 60.6%, and a specificity of 65.8%. In stratified analysis, an elevated TyG index is significantly associated with NAFLD in younger patients (<65 years; OR, 2.35; 95% CI, 1.83–3.02; P < 0.001), females (OR, 2.69; 95% CI, 1.67–4.32; P < 0.001), patients with BMI < 25 kg/m2 (OR, 2.80; 95% CI, 2.01–3.91; P < 0.0001), and with lower high-density lipoprotein cholesterol (<1 mmol/L; OR, 2.76; 95% CI, 1.98–3.83; P < 0.001). Conclusion The TyG index is remarkably associated with NAFLD and shows superior discriminative ability for NAFLD risk compared with other lipid and glycemic parameters in the T2DM population.

show abstract

The triglyceride-glucose index is associated with the severity of hepatic steatosis and the presence of liver fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults

Cited by 59 publications

References 32 publications

WHtR may be a Better and Stronger Indictor for Fatty Liver: A Population-Based Cross-sectional Comparison Study of Anthropometric and Metabolic Indices for Identification Fatty Liver in China

WHtR may be a Better and Stronger Indictor for Fatty Liver: A Population-Based Cross-sectional Comparison Study of Anthropometric and Metabolic Indices for Identification Fatty Liver in China

Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers

Association between triglyceride–glucose index and nonalcoholic fatty liver disease in type 2 diabetes mellitus

Contact Info

Product

Resources

About