The TyG Index as a Marker of Subclinical Atherosclerosis and Arterial Stiffness in Lean and Overweight Postmenopausal Women

Prediction of incident hypertension and arterial stiffness using the non–insulin‐based metabolic score for insulin resistance (METS‐IR) index

“…A significant contribution of hypertension and CVD risk is explained by arterial stiffness, which implies degeneration of elastin fibers and deposition of collagen in arterial walls, inducing structural and functional modifications in the arterial wall . The TyG index and the TG/HDL‐C ratio have proven strong and consistent associations with hypertension, CVD risk, and arterial stiffness in several populations, suggesting a potential role for IR assessment in identifying arterial stiffness using non–insulin‐based IR surrogates …”

“…8 The TyG index and the TG/HDL-C ratio have proven strong and consistent associations with hypertension, CVD risk, and arterial stiffness in several populations, suggesting a potential role for IR assessment in identifying arterial stiffness using non-insulin-based IR surrogates. 9,10 The recently developed Metabolic Score for IR (METS-IR) offers higher concordance with EHC compared with other non-insulin-based IR indexes; furthermore, METS-IR includes evaluation of body mass index (BMI), which has shown strong predictive capacity for CVD risk. 11,12 Overall, METS-IR evaluates similar components to the metabolic syndrome (MS), which has been associated with agerelated structural and functional changes in arteries and increased intima-media thickness, which confers an increased risk of hypertension and CVD.…”

Utility of obesity and metabolic dyslipidemia (a non‐insulin based determinate of the metabolic syndrome and insulin resistance) in predicting arterial stiffness

“…[2][3][4] As gold standard determinants of IR such as euglycemic clamps are laborious, lipid parameters and indices of obesity (ie, METS-IR) are increasingly being used to predict the cardiovascular risk related to the metabolic syndrome (Bello-Chavolla et al). [5][6][7] Several potential mechanisms may explain the link between lipid markers of atherosclerosis and arterial stiffness. Plasma TG and HDL-C concentrations are related to insulin-mediated glucose disposal, and many studies suggest that the TG/HDL-C ratio provides a simple way to identify individuals who are IR and are at increased cardiometabolic risk.…”

“…In this regard, it is increasingly recognized that arterial stiffness often accompanies the presence of systemic and CV IR and other components of the metabolic syndrome and it is an independent risk factor for the development of CVD and CKD . As gold standard determinants of IR such as euglycemic clamps are laborious, lipid parameters and indices of obesity (ie, METS‐IR) are increasingly being used to predict the cardiovascular risk related to the metabolic syndrome (Bello‐Chavolla et al) . Several potential mechanisms may explain the link between lipid markers of atherosclerosis and arterial stiffness.…”

“…Plasma TG and HDL‐C concentrations are related to insulin‐mediated glucose disposal, and many studies suggest that the TG/HDL‐C ratio provides a simple way to identify individuals who are IR and are at increased cardiometabolic risk. TG/HDL‐C is also regarded as a strong indicator of increased small dense low‐density lipoprotein particles which, compared with larger low‐density lipoprotein particles, exhibit a greater negative impact on endothelial stiffness and function and arterial distensibility …”