The turnover of phospholipid fatty acyl chains is activated by the insecticide Dieldrin inBufo arenarum oocytes

T, Fonovich de Schroeder; Am, Pechén de D'Angelo

doi:10.1002/(sici)1099-0461(2000)14:2<82::aid-jbt3>3.0.co;2-0

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…This activation of oocytes could also be due to modifications of Ca i that normally occur at fertilization (Stricker, 1999). Dieldrin has been reported to decrease the fertilization rate in Bufo arenarum oocytes by modifying the hydrolysis of phosphatidylinositol bisphosphate, an event that mediates Ca release from intracellular store (Fonovich et al, 2000). Effects of lindane on Ca i or on polyphosphoinositide metobolism have also been reported in various other biological models including human sperm (Silvestroni et al, 1997).…”

Section: Discussionmentioning

confidence: 97%

Effect of Organochlorine Pesticides on Maturation of Starfish and Mouse Oocytes

2005

Toxicological Sciences

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Methoxychlor, lindane, and dieldrin are organochlorine pesticides that have been described as altering different reproductive functions in mammals and in invertebrates. However, few data have been published concerning the effects these pesticides have on oocyte maturation and fertilization. The aim of this study was to determine whether these compounds could affect maturation of mouse and starfish oocytes. We observed that germinal vesicle breakdown (GVBD) in starfish oocytes was significantly inhibited by the pesticides. Furthermore, formation of the first meiotic spindle and extrusion of the first polar body were also altered in mouse as well as in starfish. Our results suggest that the three pesticides act on common intracellular targets in invertebrates as well as in vertebrates.

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Section: Discussionmentioning

confidence: 97%