In this study, histopathological changes induced by lindane a gamma isomer of hexachlorocyclohexane and its intoxication associated with reproductive system and hormone levels were investigated in zebrafish. In all, 320 zebrafish adults approximately 1 year in age, (Danio rerio) obtained from a commercial entity were used in the study. Zebrafish were divided into 8 groups, each one containing 40 zebrafish. Groups were organized as 0 (the control group), 1 ml/L methanol, and 5, 10, 20, 40, 80, 160 µg/L/day lindane. In the study, the gamma-HCH-isomer was applied at rates of 5/10/20/40/80/160 µg/L/day as doses of immersion to each group for 21 days. Macroscopically, the drop in egg production was observed, especially in the 80 and 160 µg/L/day groups of female zebrafish. A microscopic decrease in ovulation and biochemical decreases in estradiol (E 2 ) levels (40/80/160 µg/L) were also observed in the female zebrafish. As a result, lindane was found to cause changes in the reproductive system, and consequently, to cause hormonal disorders and to have significant effects on ovulation and fertilization in the female zebrafish. Anahtar Kelimeler: Zebra balığı, ovulasyon, fertilizasyon, histopatoloji.