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Abstract

In this study, histopathological changes induced by lindane a gamma isomer of hexachlorocyclohexane and its intoxication associated with reproductive system and hormone levels were investigated in zebrafish. In all, 320 zebrafish adults approximately 1 year in age, (Danio rerio) obtained from a commercial entity were used in the study. Zebrafish were divided into 8 groups, each one containing 40 zebrafish. Groups were organized as 0 (the control group), 1 ml/L methanol, and 5, 10, 20, 40, 80, 160 µg/L/day lindane. In the study, the gamma-HCH-isomer was applied at rates of 5/10/20/40/80/160 µg/L/day as doses of immersion to each group for 21 days. Macroscopically, the drop in egg production was observed, especially in the 80 and 160 µg/L/day groups of female zebrafish. A microscopic decrease in ovulation and biochemical decreases in estradiol (E 2 ) levels (40/80/160 µg/L) were also observed in the female zebrafish. As a result, lindane was found to cause changes in the reproductive system, and consequently, to cause hormonal disorders and to have significant effects on ovulation and fertilization in the female zebrafish. Anahtar Kelimeler: Zebra balığı, ovulasyon, fertilizasyon, histopatoloji.

Y-isomer of Hexachlorocyclohexane (C6H6Cl6) in Modern Human Life and Its Influence on the Processes of Oncogenesis

“…[10] This pesticide served as one of the main means of combating some insects and was widely used for fumigation of warehouses, because its lindane has powerful insecticidal properties, being a strong contact, systemic, intestinal and fumigant poison. [7] To date, it is known for sure that hexachlorocyclohexane is a polytropic toxic chemical that primarily affects the central and autonomic nervous system of mammals. Back in 1985, the Soviet scientist Professor Melnikov wrote that "all isomers of hexachlorocyclohexane have pronounced cumulative properties, especially α-, βand γ-isomers of hexachlorocyclohexane, therefore they are characterized by chronic poisoning, which in the future may be complicated by the appearance and growth of malignant neoplasms".…”

“…In particular, there is information that hexachlorocyclohexane lindanes have an antiandrogenic effect on men, which leads to insufficient development of the reproductive system: from a decrease in the size of the testicles and normal production of sperm fluid to a violation of the production of sex hormones. [7] Today, there is indisputable evidence that pesticides play a role in the development of cancer. [8] For example, in February 2019, researchers found that the accumulation of dichlorodiphenyltrichloroethane compounds in young women dramatically increases the likelihood of developing breast cancer at a more mature age due to the pathotransformation of cell physiology.…”