The Trp64Arg of β3-adrenoceptor gene and food intake in young healthy female

Trp64Arg polymorphisms of the Beta3-adrenergic receptor gene and systemic disorders of metabolism: a close association

“…The possible influence of b3AR-Trp64Arg on dietary intake behaviour would also be relevant to the development of insulin resistance and long-term exposures of harmful molecules including reactive oxygen intermediates. 6,7 In considering the difference in autonomic nerve system activity of b3AR-Trp64Arg, 8 further research on the effects of immunomodulation through autonomic nerve system on various diseases including cancer 9 is required.…”

“…Presence of the Arg64 allele also decreases the resting metabolic rate and subsequently energy expenditure in women thereby further contributing to obesity. 9 Interestingly, individuals with obstructive sleep apnoea who express the Arg64 allele are more likely to develop obesity. 10 Simultaneously, lower concentrations of HDL lipoprotein as well as higher concentrations of C-reactive protein are seen in individuals who express the Trp64/Arg64 genotype.…”