Trp64Arg polymorphisms of the Beta3-adrenergic receptor gene and systemic disorders of metabolism: a close association

The association between Trp64Arg polymorphisms of beta3-adrenergic receptor gene and systemic disorders: a possibility of prevention

“…3 Thus, we agree with Kapoor's opinion that b3AR-Trp64Arg can be closely linked with systemic disorders of metabolism. 2 Factors that disclose the linkage between b3AR-Trp64Arg and systemic metabolic disorders can be insulin resistance and the ensuing hyperinsulinaemia, 4,5 as well as increased levels of growth factors and changed levels of adipocytederived cytokines/hormones such as adiponectin. The possible influence of b3AR-Trp64Arg on dietary intake behaviour would also be relevant to the development of insulin resistance and long-term exposures of harmful molecules including reactive oxygen intermediates.…”

“…cancer of colon, breast, endometrium, kidney and oesophagus, are also recognized as one of the obesity-associated disorders. 1 Besides colon cancer, 2 we consider that gall bladder cancer may be a β3AR-Trp64Arg -related cancer, as β3AR-Trp64Arg is reportedly associated with gallstone formation. 3 Thus, we agree with Kapoor's opinion that β3AR-Trp64Arg can be closely linked with systemic disorders of metabolism.…”

“…3 Thus, we agree with Kapoor's opinion that β3AR-Trp64Arg can be closely linked with systemic disorders of metabolism. 2…”