The triglycerides and glucose index is associated with elevated blood pressure in apparently healthy children and adolescents

Simental‐Mendía, Luis E.; Hernández-Ronquillo, Gabriela; Gamboa‐Gómez, Claudia I.; Gómez-Díaz, Rita A.; Rodrı́guez-Morán, Martha; Guerrero‐Romero, Fernando

doi:10.1007/s00431-019-03392-x

Cited by 27 publications

(29 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, SUA and TG level were significantly (positively) associated with DBP and SBP in both men and women. In general, this finding is consistent with most previous studies [41,49] that suggested the high SUA and TG level were risk factors for hypertension. Although previous studies [45,50,51] have explored the association and/or interaction analysis between BMI and SUA levels and BP, no consistent results are pointing to such associations.…”

Section: Discussionsupporting

confidence: 93%

The interaction between serum uric acid and triglycerides level on blood pressure in middle-aged and elderly individuals in China: result from a large national cohort study

Zhang

Guo

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background: The purpose of the research was to explore the extent of interaction between triglycerides (TG) and serum uric acid (SUA) level with blood pressure (BP) in middle-aged and elderly individuals in China.Methods: Data were selected from the China Health and Retirement Longitudinal Study (CHARLS), a cross-sectional study. 3345(46.99%) men with average ages of 60.24 ± 9.24 years and 3774 (53.01%) women with average ages of 59.91 ± 9.95 years were included in the study. Differences between gender, or between categories of blood pressure levels were evaluated by t-test or chi-square test. The adjusted associations between various characteristics and BP status were first compared using linear regression models, as appropriate. Then, A general linear model adjusted for confounding factors (socio-demographic characteristics [age, educational levels, marital status, place of residence], health behaviors [cigarette smoking, alcohol drinking, eating habits, social and leisure activities, accidental injury, physical activities], medical history [history of cardiovascular diseases, hepatitis history, antidiabetic drugs, history of antilipidemic medication, anti-hypertensive therapy], metabolic measures [C-reactive protein (CRP), hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), estimated glomerular filtration rate (eGFR), body mass index (BMI)]) was used to examine the synergistic effect of SUA and TG level on BP in middle-aged and elderly individuals in China.Results: Age-adjusted partial Pearson's correlation coefficient showed that SUA and TG level positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP) in both men and women. Multiple linear regression analysis showed the TG level was significantly and positively associated with SBP and DBP in both men (SBP: β =0.068, P = 0.001; DBP: β =0.064, P = 0.002) and women (SBP: β =0.061, P = 0.002; DBP: β =0.084, P = 0.000), but SUA were significantly and positively associated with SBP in both men (SBP: β =0.047, P = 0.013) and women (SBP: β =0.040, P = 0.028), regardless of other confounding factors. After adjusting for related potential confounders, evidence of interaction between SUA and TG level on SBP (men: β = − 1.090, P = 0.726; women: β = − 0.692, P = 0.861) and DBP (men: β = − 1.026, P = 0.572; women: β = − 0.794, P = 0.842) was not observed. Conclusion: The interaction effect of SUA and TG level on BP was not observed in our study. Moreover, high SUA level was significantly associated with SBP, while high TG level was strongly related to both DBP and SBP.

show abstract

Section: Discussionsupporting

confidence: 93%

The interaction between serum uric acid and triglycerides level on blood pressure in middle-aged and elderly individuals in China: result from a large national cohort study

Zhang

Guo

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Although this study focuses on reporting the new and unique finding of undiagnosed prehypertension/hypertension in urban and rural adolescents in Canada, key findings related to the comorbidities for prehypertension/hypertension were also identified. Although the association between increased BP and the risk for the development of diabetes is not a new phenomenon (Jobe et al, 2017;Simental-Mendía et al, 2019;Yan et al, 2015), the current study confirmed as prehypertension/hypertension (Quaresma et al, 2019;Sharma et al, 2018;Theodore et al, 2015).…”

Section: Discussionsupporting

confidence: 53%

“…Prehypertension/hypertension is a concern within the child and adolescent population where the prevalence of prehypertension/hypertension is increasing (Falkner, 2015; Sharma, Bhattad, & Kumar, 2016; Sharma et al., 2018; Simental‐Mendía et al., 2019). Given the modifiable risk factors of prehypertension/hypertension, the increase in prevalence is alarming.…”

Section: Introductionmentioning

confidence: 99%

“…Given the modifiable risk factors of prehypertension/hypertension, the increase in prevalence is alarming. Contributing modifiable risk factors to the development of adolescent prehypertension/hypertension have been widely identified as a lack of physical exercise resulting in a high prevalence of childhood obesity (Dionne et al., 2017; Pescatello et al., 2019; Twig et al., 2016), increased sodium intake (Dionne et al., 2017; Falkner, 2015; Fan, Liao, Zong, & Zhang, 2019), and increased blood glucose measurements (Jobe, Agbla, Prentice, & Hennig, 2017; Simental‐Mendía et al., 2019; Yan et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Despite the increasing trend of adolescent prehypertension/hypertension gaining concern worldwide (Acosta, Samuels, Portman, & Redwine, 2012; Baker‐Smith et al., 2018; Falkner, 2010, 2012; Simental‐Mendía et al., 2019), there seems to be minimal programing in place to diagnose this disease early and to prevent its occurrence (Nkeh‐Chungag, Sekokotla, Sewani‐Rusike, Namugowa, & Iputo, 2015). In this Western Canadian province, the Public health nurses (PHNs) do not screen for prehypertension/hypertension in school settings and to our knowledge, there is no documented national BP screening program for Canadian adolescents.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Undiagnosed prehypertension/hypertension in Canadian adolescents: The critical role of the public health nurse

Spurr

Bullin

Bally

et al. 2020

Public Health Nursing

View full text Add to dashboard Cite

Increased blood pressure (BP), classified as either prehypertension or hypertension, is a measurable increase in the force of circulating blood within the vessels of the heart (American Heart Association, 2020). High BP can predispose individuals to serious health complications, such as ischemic heart disease, stroke, heart failure, and diabetes (American Heart Association, 2020). Furthermore, complications resulting from prehypertension/hypertension in the adolescent population have commonly been associated with increased risk for future cardiovascular disease (Assadi, 2014; Mehta et al., 2016). Although complications related to child and adolescent prehypertension/hypertension are not typically critical, physiological changes, such as left ventricular hypertrophy, changes to retinal and carotid vessels, and target organ damage, have been discovered in adolescents with prehypertension/hypertension (Badeli et al., 2016; Falkner, 2015).

show abstract

Altered triglyceride glucose index and fasted serum triglyceride high‐density lipoprotein cholesterol ratio predict incidence of cardiovascular disease in the Mashhad cohort study

et al. 2022

View full text Add to dashboard Cite

The triglyceride glucose (TyG) index and triglyceride/high lipoprotein density cholesterol (TG/HDL‐C) are two important risk markers to evaluate the insulin resistance and cardiovascular diseases (CVDs). To assess the association between TG/HDL‐C and TyG index and CVDs. The Mashhad stroke and heart association disorder cohort study started in 2010 and has been continued until 2020. During 6‐year follow‐up of 9704 participants, 235 events including 118 acute coronary syndrome (ACS), 83 chronic coronary syndrome, 27 myocardial infarction, and 27 cardiac death were confirmed. SPSS software (version 21) was used for statistical analysis and figures were drawn by GraphPad Prism 6 software. The prevalence of ACS and cardiac death were higher in the fourth quartile of serum TG/HDL‐C (>4.43) and higher prevalence of ACS was considered in subjects classified in the fourth quartile of TyG index (>8.98). A high TyG index was associated with an increased risk of ACS and cardiac death [1.362 (95% confidence interval [CI]: [1.013–1.831]) and 2.3 (95% CI: [1.247–4.241])] respectively; based on Cox regression analysis elevated TyG and TG/HDL‐C increased the chance of CVD by [1.634 (95% CI: 1.304–2.047) and 1.068 (95% CI: 1.031–1.105)], respectively. Our results strongly showed that TyG index and TG/HDL‐C are independent risk factors for incident CVD, suggesting that TyG index and TG/HDL‐C may be as an important unique biomarker for predicting CVD outcomes and progression.

show abstract

The triglycerides and glucose index is associated with elevated blood pressure in apparently healthy children and adolescents

Cited by 27 publications

References 27 publications

The interaction between serum uric acid and triglycerides level on blood pressure in middle-aged and elderly individuals in China: result from a large national cohort study

The interaction between serum uric acid and triglycerides level on blood pressure in middle-aged and elderly individuals in China: result from a large national cohort study

Undiagnosed prehypertension/hypertension in Canadian adolescents: The critical role of the public health nurse

Altered triglyceride glucose index and fasted serum triglyceride high‐density lipoprotein cholesterol ratio predict incidence of cardiovascular disease in the Mashhad cohort study

Contact Info

Product

Resources

About